Pseudoepitheliomatous hyperplasia: A review

American Journal of Dermatopathology

Volumn 33, Issue 2, 2011, Pages 112-126

  Zayour, Maya ^b   Lazova, Rossitza ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

epidermal hyperplasia; epithelial hyperplasia; pseudocarcinomatous; Pseudoepitheliomatous

Indexed keywords

BACTERIAL INFECTION; CHRONIC INFLAMMATION; CLINICAL FEATURE; DISEASE ASSOCIATION; EPIDERMIS HYPERPLASIA; HISTOPATHOLOGY; HUMAN; INFECTION; INFLAMMATION; MYCOSIS; PRIORITY JOURNAL; PROTOZOAL INFECTION; PSEUDOEPITHELIOMATOUS HYPERPLASIA; REVIEW; SKIN DISEASE; SQUAMOUS CELL CARCINOMA; VIRUS INFECTION;

CARCINOMA, SQUAMOUS CELL; DIAGNOSIS, DIFFERENTIAL; EPITHELIUM; HUMANS; HYPERPLASIA; SKIN NEOPLASMS;

EID: 79952806377     PISSN: 01931091     EISSN: None     Source Type: Journal    
DOI: 10.1097/DAD.0b013e3181fcfb47     Document Type: Review

References (107)

1. Kao GF, Farmer ER. Benign tumors and carcinoma in situ of the epidermis. In: Farmer ER, Hood AF, eds. Pathology of the Skin. New York, NY: McGraw-Hill Health Professions Division; 2000: 946-965.
2. Bartralot R, Pujol RM, Garcia-Patos V, et al. Cutaneous infections due to nontuberculous mycobacteria: histopathological review of 28 cases. Comparative study between lesions observed in immunosuppressed patients and normal hosts. J Cutan Pathol. 2000;27:124-129. (Pubitemid 30113782)
3. Grayson W, Calonje E, McKee PH. Infectious diseases of the skin. In: McKee PH, Calonje E, Granter SR, eds. Pathology of the Skin: With Clinical Correlations. London, PA: Elsevier Mosby; 2005:900.
4. Grauwin MY, Mane I, Cartel JL. Pseudoepitheliomatous hyperplasia in trophic ulcers in leprosy patients. A 28-case study Lepr Rev. 1996;67:203-207. (Pubitemid 26317078)
5. Kampirapap K, Poonpracha T. Squamous cell carcinoma arising in chronic ulcers in leprosy JMed Assoc Thai. 2005;88:58-61. (Pubitemid 40824411)
6. Swamy S, Durai V, Oommen PK, et al. Cauliflower growths in trophic ulcers of leprosy\a 10 year study Indian JLepr. 1986;58:48-53. (Pubitemid 17173500)
7. Chandler FW, Watts JC Pathologic Diagnosis of Fungal Infections. Chicago, IL: ASCP Press; 1987: xiii 303.
8. Barr CC, Gamel JW. Blastomycosis of the eyelid. Arch Ophthalmol. 1986;104:96-97. (Pubitemid 16172238)
9. Kaminagakura E, Bonan PR, Lopes MA, et al. Cell proliferation and p53 expression in pseudoepitheliomatous hyperplasia of oral paracoccidioi-domycosis. Mycoses. 2006;49:393-396. (Pubitemid 44213881)
10. Kaminagakura E, Graner E, de Almeida OP, et al. Oral para- coccidioidomycosis or squamous cell carcinoma? Gen Dent. 2004;52: 48-50. (Pubitemid 39118620)
11. Kwangsukstith C, Vanittanakom N, Khanjanasthiti P, et al. Cutaneous sporotrichosis in Thailand: first reported case. Mycoses. 1990;33:513-517.
12. Bayerl C, Fuhrmann E, Coelho CC, et al. Expression of heat shock protein 27 in chromomycosis. Mycoses. 1998;41:447-452. (Pubitemid 29042368)
13. McGinnis MR. Chromoblastomycosis and phaeohyphomycosis: new concepts, diagnosis, andmycology JAm Acad Dermatol. 1983;8:1-16. (Pubitemid 13221132)
14. Pradhan SV, Talwar OP, Ghosh A, et al. Chromoblastomycosis in Nepal: a study of 13 cases. Indian J Dermatol Venereol Leprol. 2007;73: 176-178. (Pubitemid 46918512)
15. Uribe F, Zuluaga AI, Leon W, et al. Histopathology of chromoblasto-mycosis. Mycopathologia. 1989;105:1-6.
16. Quimby SR, Connolly SM, Winkelmann RK, et al. Clinicopathologic spectrum of specific cutaneous lesions of disseminated coccidioidomy-cosis. J Am Acad Dermatol. 1992;26:79-85.
17. Goel R, Wallace ML. Pseudoepitheliomatous hyperplasia secondary to cutaneous aspergillus. Am J Dermatopathol. 2001;23:224-226. (Pubitemid 32525413)
18. Khatri ML, Stefanato CM, Benghazeil M, et al. Cutaneous and paranasal aspergillosis in an immunocompetent patient. Int J Dermatol. 2000;39: 853-856. (Pubitemid 32010940)
19. Mosunjac M, Park J, Wang W, et al. Genital and perianal herpes simplex simulating neoplasia in patients with AIDS. AIDS Patient Care STDS. 2009;23:153-158.
20. LeBoit PE, Limova M, Yen TS, et al. Chronic verrucous varicella-zoster virus infection in patients with the acquired immunodeficiency syndrome (AIDS). Histologic and molecular biologic findings. Am J Dermatopa-thol. 1992;14:1-7.
21. Vaughan Jones SA, McGibbon DH, Bradbeer CS. Chronic verrucous varicella-zoster infection in a patient with AIDS. Clin Exp Dermatol. 1994;19:327-329. (Pubitemid 24231236)
22. Nguyen RT, Beardmore GL. Blastomycosis-like pyoderma: successful treatment with low-dose acitretin. Australas J Dermatol. 2005;46: 97-100. (Pubitemid 40704887)
23. Sawalka SS, Phiske MM, Jerajani HR. Blastomycosis-like pyoderma. Indian J Dermatol Venereol Leprol. 2007;73:117-119. (Pubitemid 46675039)
24. Su WP, Duncan SC, Perry HO. Blastomycosis-like pyoderma. Arch Dermatol. 1979;115:170-173. (Pubitemid 9115722)
25. Amsbaugh S, Huiras E, Wang NS, et al. Bacillary angiomatosis associated with pseudoepitheliomatous hyperplasia. Am J Dermatopathol. 2006;28:32-35. (Pubitemid 44366178)
26. Deshpande RB, Bharucha MA. Median rhomboid glossitis: secondary to colonisation of the tongue by Actinomyces (a case report). J Postgrad Med. 1991;37:238-240.
27. Kikham N. Tumors and cyst of the skin. In: Elder D, Elenitsas R, Johnson B, et al, eds. Lever's Histopathology of the Skin. Philadelphia, PA: Lippincott Williams & Wilkins; 2005:836.
28. Wagner RF Jr, Grande DJ. Pseudoepitheliomatous hyperplasia vs. squamous cell carcinoma arising from chronic osteomyelitis of the humerus. JDermatol Surg Oncol. 1986;12:632-635. (Pubitemid 16061155)
29. Warter A, Walter P, Meyer C, et al. Mandibular pseudocarcinomatous hyperplasia. Histopathology. 2000;37:115-117. (Pubitemid 30608508)
30. Akilov OE, Donovan MJ, Stepinac T, et al. T helper type 1 cytokines and keratinocyte growth factor play a critical role in pseudoepitheliomatous hyperplasia initiation during cutaneous leishmaniasis. Arch Dermatol Res. 2007;299:315-325. (Pubitemid 47282757)
31. Tuttle MS, Rosenberg AS, Winfield HL, et al. Pseudocarcinomatous hyperplasia with follicular differentiation overlying basal cell carcinoma. Am J Dermatopathol. 2009;31:557-560.
32. Kuo TT, Shih LY, Tsang NM. Nasal NK/T cell lymphoma in Taiwan: a clinicopathologic study of 22 cases, with analysis of histologic subtypes, Epstein-Barr virus LMP-1 gene association, and treatment modalities. Int J Surg Pathol. 2004;12:375-387.
33. Valiathan M, Rao RV Rao L, et al. Nasal NK/T cell lymphoma mimicking a squamous cell carcinoma: a case report. Indian J Pathol Microbiol. 2005;48:257-259. (Pubitemid 44783508)
34. Zayour M, Gilmore E, Heald P, et al. A distinct entity in the spectrum of the CD30+ cutaneous lymphoproliferative diseases: oligolesional nodules with pseudoepitheliomatous hyperplasia followed by spontane-ous resolution. Am J Dermatopathol. 2009;31:37-43.
35. Courville P, Wechsler J, Thomine E, et al. Pseudoepitheliomatous hyperplasia in cutaneous T-cell lymphoma. A clinical, histopathological and immunohistochemical study with particular interest in epithelial growth factor expression. The French Study Group on Cutaneous Lymphoma. Br J Dermatol. 1999;140:421-426. (Pubitemid 29182871)
36. Bernier M, Bagot M, Broyer M, et al. Distinctive clinicopathologic features associated with regressive primary CD30 positive cutane-ous lymphomas: analysis of 6 cases. J Cutan Pathol. 1997;24: 157-163. (Pubitemid 27117371)
37. Cespedes YP, Rockley PF, Flores F, et al. Is there a special relationship between CD30-positive lymphoproliferative disorders and epidermal proliferation? J Cutan Pathol. 2000;27:271-275. (Pubitemid 30389566)
38. Lin JH, Lee JY Primary cutaneous CD30 anaplastic large cell lymphoma with keratoacanthoma-like pseudocarcinomatous hyperplasia and marked eosinophilia and neutrophilia. J Cutan Pathol. 2004;31: 458-461. (Pubitemid 38845138)
39. Scarisbrick JJ, Calonje E, Orchard G, et al. Pseudocarcinomatous change in lymphomatoid papulosis and primary cutaneous CD30+ lymphoma: a clinicopathologic and immunohistochemical study of 6 patients. JAm Acad Dermatol. 2001;44:239-247. (Pubitemid 32172185)
40. Sugiyama H, Asagoe K, Morizane S, et al. Leukocyte common antigen-negative, aggressive cutaneous anaplastic large cell lymphoma with prominent pseudocarcinomatous hyperplasia. Eur J Dermatol. 2008;18: 74-77. (Pubitemid 351158177)
41. Resnik KS, Kutzner H. Mimicry illuminating pitfalls in histopathologic diagnosis: nutritional deficiency-like dermatitis secondary to topical tazarotene and keratoacanthomatous pseudocarcinomatous hyperplasia in CD30+ lymphoproliferative disorder as illustrative. Am J Dermato-pathol. 2009;31:22-25.
42. Brannon RB, Anand PM. Oral granular cell tumors: an analysis of 10 new pediatric and adolescent cases and a review of the literature. J Clin Pediatr Dent. 2004;29:69-74. (Pubitemid 39531128)
43. Torrijos-Aguilar A, Alegre-de Miquel V Pitarch-Bort G, et al. [Cutaneous granular cell tumor: a clinical and pathologic analysis of 34 cases]. Actas Dermosifiliogr. 2009;100:126-132.
44. Hanly AJ, Jorda M, Elgart GW. Cutaneous malignant melanoma associated with extensive pseudoepitheliomatous hyperplasia. Report of a case and discussion of the origin of pseudoepitheliomatous hyperplasia. J Cutan Pathol. 2000;27:153-156. (Pubitemid 30113787)
45. Meleti M, Mooi WJ, van der Waal I. Oral malignant melanoma associated with pseudoepitheliomatous hyperplasia. Report of a case. J Cutan Pathol. 2006;33:331-333.
46. Mott RT, Rosenberg A, Livingston S, et al. Melanoma associated with pseudoepitheliomatous hyperplasia: a case series and investigation into the role of epidermal growth factor receptor. J Cutan Pathol. 2002;29: 490-497. (Pubitemid 35034460)
47. Vucic M, Cupic H, Tomic K, et al. An unusual pattern of pseudoepitheliomatous hyperplasia associated with cutaneous primary melanoma: report of two cases with analysis of p53 and bcl-2 immunoreactivity. Acta Dermatovenerol Croat. 2007;15:72-75. (Pubitemid 47203485)
48. Dorji T, Cavazza A, Nappi O, et al. Spitz nevus of the tongue with pseudoepitheliomatous hyperplasia: report of three cases of a pseudo-malignant condition. Am J Surg Pathol. 2002;26:774-777. (Pubitemid 34546943)
49. Eroglou A, Ugurluoglu C Spitz nevus of the tongue with pseudoepi-theliomatous hyperplasia: a case report. JBUON. 2005;10:555-557.
50. Scott G, Chen KT, Rosai J. Pseudoepitheliomatous hyperplasia in Spitz nevi. A possible source of confusion with squamous cell carcinoma. Arch Pathol Lab Med. 1989;113:61-63. (Pubitemid 19029752)
51. Weigelt N, Metze D, Stander S. Prurigo nodularis: systematic analysis of 58 histological criteria in 136 patients. J Cutan Pathol. 2010;37:578-586.
52. Blasik LG, Spencer SK. Fluoroderma. Arch Dermatol. 1979;115: 1334-1335. (Pubitemid 10156833)
53. Heydenreich G, Larsen PO. Iododerma after high dose urography in an oliguric patient. Br J Dermatol. 1977;97:567-569. (Pubitemid 8214662)
54. Kincaid MC, Green WR, Hoover RE, et al. Iododerma of the conjunctiva and skin. Ophthalmology. 1981;88:1216-1220. (Pubitemid 12251165)
55. Wilkin JK, Strobel D. Iododerma occurring during thyroid protection treatment. Cutis. 1985;36:335-337. (Pubitemid 16226347)
56. Bel S, Bartralot R, Garcia D, et al. Vegetant bromoderma in an infant. Pediatr Dermatol. 2001;18:336-338. (Pubitemid 32847912)
57. Maffeis L, Musolino MC, Cambiaghi S. Single-plaque vegetating bromoderma. JAm Acad Dermatol. 2008;58:682-684. (Pubitemid 351384688)
58. Kaplan RP. Cancer complicating chronic ulcerative and scarifying mucocutaneous disorders. Adv Dermatol. 1987;2:19-46.
59. Hagiwara K, Uezato H, Miyazato H, et al. Squamous cell carcinoma arising from lupus vulgaris on an old burn scar: diagnosis by polymerase chain reaction. J Dermatol. 1996;23:883-889. (Pubitemid 27066185)
60. Motswaledi MH, Doman C Lupus vulgaris with squamous cell carcinoma. J Cutan Pathol. 2007;34:939-941. (Pubitemid 350139029)
61. Yerushalmi J, Grunwald MH, Halevy DH, et al. Lupus vulgaris complicated by metastatic squamous cell carcinoma. Int J Dermatol. 1998;37:934-935. (Pubitemid 29012785)
62. Perniciaro C, Randle HW, Perry HO. Hypertrophic discoid lupus erythematosus resembling squamous cell carcinoma. Dermatol Surg. 1995;21:255-257.
63. Daldon PE, Macedo de Souza E, Cintra ML. Hypertrophic lupus erythematosus: a clinicopathological study of 14 cases. J Cutan Pathol. 2003;30:443-448. (Pubitemid 36926357)
64. Kar BR, Nair V, Ebenezer G, et al. Squamous cell carcinoma of the scalp arising from chronic cutaneous lupus erythematosus: report of two Indian patients. Indian J Dermatol Venereol Leprol. 2004;70: 236-238. (Pubitemid 39266844)
65. Ee HL, Ng PP, Tan SH, et al. Squamous cell carcinoma developing in two Chinese patients with chronic discoid lupus erythematosus: the need for continued surveillance. Clin Exp Dermatol. 2006;31:542-544. (Pubitemid 43806589)
66. Garrett AB. Multiple squamous cell carcinomas in lesions of discoid lupus erythematosus. Cutis. 1985;36:313-314, 316.
67. Tan E, Malik R, Quirk CJ. Hypertrophic lichen planus mimicking squamous cell carcinoma. Australas J Dermatol. 1998;39:45-47. (Pubitemid 28217015)
68. Goldberg NS, Esterly NB, Rothman KF, et al. Perianal pseudoverrucous papules and nodules in children. Arch Dermatol. 1992;128:240-242.
69. Vaccaro M, Borgia F, Guarneri F, et al. Elephantiasis nostras verrucosa. Int J Dermatol. 2000;39:764-766.
70. Gattuso P, Candel AG, Castelli MJ, et al. Pseudoepitheliomatous hyperplasia in chronic cutaneous wounds. A flow cytometric study J Cutan Pathol. 1994;21:312-315. (Pubitemid 24280415)
71. Hurwitz RM. Pseudocarcinomatous or infundibular hyperplasia. Am J Dermatopathol. 1989;11:189-192.
72. Lee ES, Allen D, Scurry J. Pseudoepitheliomatous hyperplasia in lichen sclerosus of the vulva. Int J Gynecol Pathol. 2003;22:57-62. (Pubitemid 36014277)
73. Diapera MJ, Lozon CL, Thompson LD. Malacoplakia of the tongue: a case report and clinicopathologic review of 6 cases. Am J Otolaryngol. 2009;30:101-105.
74. Nigen S, Poulin Y, Rochette L, et al. Pyodermatitis-pyostomatitis vegetans: two cases and a review of the literature. J Cutan Med Surg. 2003;7:250-255. (Pubitemid 36859105)
75. Kaiser J, Kaatz M, Elsner P, et al. Complete remission of drug-resistant pemphigus vegetans treated by extracorporeal photopheresis. J Eur Acad Dermatol Venereol. 2007;21:843-844. (Pubitemid 46939073)
76. Madan V, August PJ. Exophytic plaques, blisters, and mouth ulcers. Pemphigus vegetans (PV), Neumann type. Arch Dermatol. 2009;145: 715-720.
77. Danopoulou I, Stavropoulos P, Stratigos A, et al. Pemphigus vegetans confinedto the scalp. Int J Dermatol. 2006;45:1008-1009.
78. Morizane S, Yamamoto T, Hisamatsu Y et al. Pemphigus vegetans with IgG and IgA antidesmoglein 3 antibodies. Br J Dermatol. 2005;153: 1236-1237. (Pubitemid 41779591)
79. de Almeida HL Jr, Neugebauer MG, Guarenti IM, et al. Pemphigus vegetans associated with verrucous lesions: expanding a phenotype. Clinics (Sao Paulo). 2006;61:279-282. (Pubitemid 44047818)
80. Kim J, Chavel S, Girardi M, et al. Pemphigoid vegetans: a case report and reviewof the literature. J Cutan Pathol. 2008;35:1144-1147.
81. Chan LS, Dorman MA, Agha A, et al. Pemphigoid vegetans represents a bullous pemphigoid variant. Patient's IgG autoantibodies identify the major bullous pemphigoid antigen. JAm Acad Dermatol. 1993;28(2 pt 2):331-335. (Pubitemid 23056282)
82. Kuokkanen K, Helin H. Pemphigoid vegetans. Report of a case. Arch Dermatol. 1981;117:56-57. (Pubitemid 11098626)
83. Breton AL, Chandeclerc ML, Lefaure C, et al. [Pemphigus vegetans]. Ann Dermatol Venereol. 2008;135:798-799.
84. Balfour E, Olhoffer I, Leffell D, et al. Massive pseudoepitheliomatous hyperplasia: an unusual reaction to a tattoo. Am J Dermatopathol. 2003; 25:338-340. (Pubitemid 36897338)
85. Cui W, McGregor DH, Stark SP, et al. Pseudoepitheliomatous hyperplasia\an unusual reaction following tattoo: report of a case and review of the literature. Int J Dermatol. 2007;46:743-745. (Pubitemid 47046197)
86. Kluger N, Durand L, Minier-Thoumin C, et al. Pseudoepitheliomatous epidermal hyperplasia in tattoos: report of three cases. Am J Clin Dermatol. 2008;9:337-340.
87. Calhoun KH, Wagner RF Jr, Kumar D, et al. Pseudoepitheliomatous hyperplasia mistaken for cancer after delayed reconstruction. South Med J. 1995;88:454-457.
88. Weber PJ, Johnson BL, Dzubow LM. Pseudoepitheliomatous hyperpla-sia following Mohs micrographic surgery. JDermatol Surg Oncol. 1989; 15:557-560. (Pubitemid 19132263)
89. Grunwald MH, Lee JY, Ackerman AB. Pseudocarcinomatous hyper-plasia. Am J Dermatopathol. 1988;10:95-103.
90. Ackerman AB, Guo Y Vitale P. Differential Diagnosis in Dermatopa-thology I. Chicago, IL: American Society ofClinical Pathologists; 1992: 121.
91. Lee YS, Teh M. p53 expression in pseudoepitheliomatous hyperplasia, keratoacanthoma, and squamous cell carcinoma of skin. Cancer. 1994; 73:2317-2323.
92. Galan A, Ko CJ. Langerhans cells in squamous cell carcinoma vs. pseudoepitheliomatous hyperplasia of the skin.J Cutan Pathol. 2007;34: 950-952. (Pubitemid 350131999)
93. Gray ST, Wilkins RJ, Yun K Interstitial collagenase gene expression in oral squamous cell carcinoma. Am J Pathol. 1992;141:301-306.
94. Muller D, Wolf C, Abecassis J, et al. Increased stromelysin 3 gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas. Cancer Res. 1993;53:165-169. (Pubitemid 23019393)
95. Zarovnaya E, Black C Distinguishing pseudoepitheliomatous hyper-plasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck. Arch Pathol Lab Med. 2005;129:1032-1036. (Pubitemid 41060642)
96. Impola U, Jeskanen L, Ravanti L, et al. Expression of matrix metalloproteinase (MMP)-7 and MMP-13 and loss of MMP-19 and p16 are associated with malignant progression in chronic wounds. Br J Dermatol. 2005;152:720-726. (Pubitemid 40571305)
97. Hojilla CV, Mohammed FF, Khokha R. Matrix metalloproteinases and their tissue inhibitors direct cell fate during cancer development. Br J Cancer. 2003;89:1817-1821. (Pubitemid 37533251)
98. Kerkela E, Saarialho-Kere U. Matrix metalloproteinases in tumor progression: focus on basal and squamous cell skin cancer. Exp Dermatol. 2003;12:109-125. (Pubitemid 36934696)
99. Saarialho-Kere U, Kerkela E, Jahkola T, et al. Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair. J Invest Dermatol. 2002;119:14-21. (Pubitemid 35304384)
100. Hirsh BC, Johnson WC. Pathology of granulomatous diseases. Mixed inflammatory granulomas. Int J Dermatol. 1984;23:585-597. (Pubitemid 15219375)
101. Johnson LL, Kempson RL. Epidermoid carcinoma in chronic osteomyelitis: diagnostic problems and management. JBone Joint Surg Am. 1965;47:133-145.
102. Bauer T, David T, Rimareix F, et al. [Marjolin's ulcer in chronic osteomyelitis: seven cases and a review of the literature]. Rev Chir Orthop Reparatrice Appar Mot. 2007;93:63-71.
103. Tronnier M, Merz H. [Anaplastic large cell lymphoma and keratoacan-thoma]. Hautarzt. 2004;55:182-185. (Pubitemid 38391407)
104. Suzuki T, Kumamoto H, Nagasaka H, et al. Intramucosal naevus with pseudoepitheliomatous hyperplasia in the gingiva: a case report. Int J Oral Maxillofac Surg. 2002;31:330-333.
105. Goette DK, Helwig EB. Basal cell carcinomas andbasal cell carcinoma-like changes overlying dermatofibromas. Arch Dermatol. 1975;111: 589-592.
106. Navarini AA, Kerl K, French LE, et al. Control of widespread hypertrophic lupus erythematosus with T-cell-directed biologic efalizumab. Dermatology. 2010;220:249-253
107. Kluger N.Issues with keratoacanthoma, pseudoepitheliomatous hyper-plasia and squamous cell carcinoma within tattoos: a clinical point of view J Cutan Pathol. 2010;37:812-813.