Whey proteins as source of dipeptidyl dipeptidase IV (dipeptidyl peptidase-4) inhibitors

Peptides

Volumn 32, Issue 4, 2011, Pages 835-838

  Tulipano, Giovanni ^a   Sibilia, Valeria ^b   Caroli, Anna Maria ^a   Cocchi, Daniela ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTOGLOBULIN; BETA LACTOSIN A; DIPEPTIDYL PEPTIDASE IV INHIBITOR; ISOLEUCYLPROLYLALANINE; MILK PROTEIN; PEPTIDE; PROTEIN HYDROLYSATE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BOVIDS; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; PRIORITY JOURNAL;

CASE-CONTROL STUDIES; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; HUMANS; MILK PROTEINS;

EID: 79952799368     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2011.01.002     Document Type: Article

References (19)

1. Drucker DJ. The biology of incretin hormones. Cell Metab 2006;3:153-65.
2. Darmoul D, Voisin T, Couvineau A, Rouyer-Fessard C, Salomon R, Wang Y, Swallow DM, Laburthe M. Regional expression of epithelial dipeptidyl peptidase IV in the human intestines. Biochem Biophys Res Commun 1994;203:1224-9. (Pubitemid 24304960)
3. Holst JJ, Deacon CF. Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes. Diabetes 1998;47:1663-70. (Pubitemid 28476238)
4. Drab SR. Incretin-based therapy for type-2 diabetes mellitus: current status and future prospects. Pharmacotherapy 2010;30:609-24.
5. Gunnarsson PT, Winzell MS, Deacon CF, Larsen MO, Jelic K, Carr RD, Ahrèn B. Glucose-induced incretin hormone release and inactivation are differently modulated by oral fat and protein in mice. Endocrinology 2006;147:3173-80. (Pubitemid 43901106)
6. Drucker DJ. Enhancing the action of incretin hormones: a new whey forward? Endocrinology 2006;147:3171-2.
7. Hansen L, Deacon CF, Orskov C, Holst JJ. Glucagone-like peptide-1-(7-36) amide is transformed to glucagon-like-peptide-1-(9-36) amide by dipeptidyl peptidase IV (DPPIV) in the capillaries supplying the L cells on the porcine intestine. Endocrinology 1999;140:5356-63.
8. Meisel H. Biochemical properties of regulatory peptides derived from milk proteins. Biopolymers 1997;43:119-28. (Pubitemid 27291390)
9. Lorenzini EC, Chessa S, Chiatti F, Caroli A, Pagnacco G. Peptidi bioattivi di latte e derivati. Scienza e Tecnica lattiero-casearia 2007;58:113-56.
10. Hernandez-Ledesma B, Recio I, Amigo L. Beta-lactoglobulin as a source of bioactive peptides. Amino Acids 2008;35:257-65.
11. Nilsson M, Stenberg M, Frid AH, Holst JJ, Bjorck IM. Glycemia and insulinemia in healthy subjects after lactose-equivalent meals and other food proteins: the role of plasma amino acids and incretins. Am J Clin Nutr 2004;80:1246-53. (Pubitemid 41350685)
12. Frid AH, Nilsson M, Holst JJ, Bjorck IM. Effect of whey on blood glucose and insulin responses to composite breakfast and lunch meals in type 2 diabetic subjects. Am J Clin Nutr 2005;82:69-75. (Pubitemid 41716379)
13. Manders RJ, Koopman R, Sluijsmans WE, van den Berg R, Verbeek K, Saris WH, Wagenmakers AJ, van Loon LJ. Co-ingestion of a protein hydrolysate with or without additional leucine effectively reduces postprandial blood glucose excursions in type 2 diabetic men. J Nutr 2006;136:1294-9.
14. Petersen BL, Ward LS, Bastian ED, Jenkins AL, Campbell J, Vuksan V. A whey protein supplement decreases post-prandial glycemia. Nutr J 2009;8:47.
15. Mrestani-Klaus C, Fengler A, Faust J, Brandt W, Wrenger S, Reinhold D, Ansorge S, Neubert K. N-terminal HIV-1 Tat nonapeptides as inhibitors of dipeptidyl peptidase IV conformational characterization. Adv Exp Med Biol 2000;477:125-9. (Pubitemid 32173997)
16. Lorey S, Stockel-Maschek A, Faust J, Stiebitz B, Gorrel MD, Kahne T, Mrestani-Klaus C, Wrenger S, Reinhold D, Ansorge S, Neubert K. Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites. Eur J Biochem 2003;270:2147-56. (Pubitemid 36605566)
17. Leiting B, Pryor KD, Wu JK, Marsilio F, Patel RA, Craik CS, Ellman JA, Cummings RT, Thornberry NA. Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII. Biochem J 2003;371:525-32. (Pubitemid 36547636)
18. Morifuji M, Koga J, Kawanaka K, Higuchi M. Branched-chain amino acid-containing dipeptides, identified from whey protein hydrolysates, stimulate glucose uptake rate in L6 myotubes and isolated skeletal muscles. J Nutr Sci Vitaminol 2009;55:81-6.
19. Abubakar A, Saito T, Kitazawa H, Kawai Y, Itoh T. Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J Dairy Sci 1998;81:3131-8. (Pubitemid 128444864)