Synthesis and biodistribution of a novel 99mTcN complex of norfloxacin dithiocarbamate as a potential agent for bacterial infection imaging

Bioconjugate Chemistry

Volumn 22, Issue 3, 2011, Pages 369-375

  Zhang, Shijian ^a   Zhang, Weifang ^b   Wang, Yue ^a   Jin, Zhonghui ^b   Wang, Xuebin ^a   Zhang, Junbo ^a   Zhang, Yanyan ^b  

^a BEIJING NORMAL UNIVERSITY   (China)

^b PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BINDING ENERGY; ELECTROPHORESIS; MAMMALS; PARTICLE BEAMS; PHOTONS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; THIN LAYER CHROMATOGRAPHY;

BACTERIAL INFECTIONS; BIODISTRIBUTIONS; DITHIOCARBAMATES; FLUOROQUINOLONES; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HIGHER YIELD; NORFLOXACIN; RADIOCHEMICAL PURITY; SYNTHESISED; THIN-LAYER CHROMATOGRAPHY;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

CIPROFLOXACIN; NORFLOXACIN; NORFLOXACIN DITHIOCARBAMATE TCN 99M; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ABSCESS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; BINDING AFFINITY; BINDING ASSAY; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG PURITY; DRUG SYNTHESIS; DRUG UPTAKE; ELECTROPHORESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFECTION RATE; ISOTOPE LABELING; LIPOPHILICITY; MOUSE; MUSCLE; NONHUMAN; PARTITION COEFFICIENT; RADIOCHEMISTRY; ROOM TEMPERATURE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THIN LAYER CHROMATOGRAPHY;

BACTERIA (MICROORGANISMS); MUS;

EID: 79952777130     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc100357w     Document Type: Article

References (21)

1. Lucignani, G. (2007) The many roads to infection imaging Eur. J. Nucl. Med. Mol. Imaging 34, 1873-1877 (Pubitemid 47599069)
2. Gemmel, F., Dumarey, N., and Welling, M. (2009) Future diagnostic agents Semin. Nucl. Med. 39, 11-26
3. Laverman, P., Bleeker-Rovers, C. P., Corstens, F. H. M., Boerman, O. C., and Oyen, W. J. G. (2008) Development of infection and inflammation targeting compounds Curr. Radiopharm. 1, 42-48
4. Palestro, C. J. (2007) In vivo leukocyte labeling: the quest continues J. Nucl. Med. 48, 332-334 (Pubitemid 47604912)
5. Britton, K. E., Vinjamuri, S., Hall, A. V., Solanki, K. K., Bomanji, J., and Das, S. (1997) Clinical evaluation of technetium-99m infecton for the localisation of bacterial infection Eur. J. Nucl. Med. 24, 553-556 (Pubitemid 27239215)
6. 99mTc infecton imaging with radiolabelled white-cell imaging in the evaluation of bacterial infection Lancet 347, 233-235
7. 99mTc-infecton, a novel agent for detecting sites of infection J. Clin. Pathol. 51, 215-219 (Pubitemid 28216078)
8. 99mTc-ciprofloxacin (Infecton) J. Clin. Pathol. 55, 817-823 (Pubitemid 35316247)
9. 99mTc-ciprofloxacin J. Nucl. Med. 45, 2088-2094 (Pubitemid 47611640)
10. 99mTc-ciprofloxacin by different methods and its biodistribution Appl. Radiat. Isot. 57, 193-200 (Pubitemid 34607656)
11. 99mTc- ciprofloxacin preparation and quality control J. Labelled Compd. Radiopharm. 49, 1171-1176 (Pubitemid 44913061)
12. 99mTc- radiopharmaceuticals containing the TcN multiple bond Appl. Radiat. Isot. 43, 1329-1333
13. Pasqualini, R., Duatti, A., Bellande, E., Comazzi, V., Brucato, V., Hoffschir, D., Fagret, D., and Comet, M. (1994) Bis(dithiocarbamato) nitrido technetium-99m radiopharmaceuticals: a class of neutral myocardial imaging agents J. Nucl. Med. 35, 334-341 (Pubitemid 24048324)
14. Baldas, J., Bonnyman, J., Pojer, P. M., Williams, G. A., and Mackay, M. F. (1981) Synthesis and structure of bis(diethyldithiocarbamato) nitrido technetium(V): technetium nitrogen triple bond J. Chem. Soc. Dalton Trans. 1798-1801
15. 99mTcN complex of ciprofloxacin dithiocarbamate as a potential agent for infection imaging Bioorg. Med. Chem. Lett. 18, 5168-5170
16. Domagala, J. M., Heifetz, C. L., Huff, M. P., Mich, T. F., Nichols, J. B., Solomon, M., and Worth, D. F. (1988) 1-Substituted 7-[3-[(ethy1amino) methyl]-l-pyrrolidinyl]- 6,8-difluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials J. Med. Chem. 31, 991-1001
17. 99mTc J. Chin. Clin. Med. Imaging 17, 42-44
18. m-citrate for tumour and inflammation scintigraphy Nucl. Med. Commun. 17, 979-985 (Pubitemid 26414208)
19. Welling, M. M., Paulusma-Anneme, A., Balter, H. S., Pauwels, E. K. J., and Nibbering, P. H. (2000) Technetium-99m labelled antimicrobial peptides discriminate between bacterial infections and sterile inflammations Eur. J. Nucl. Med. 27, 292-301 (Pubitemid 30167699)
20. 18F]FDG Nucl. Med. Commun. 31, 239-248
21. Chu, D. T. W. and Fernandes, P. B. (1989) Structure-activity relationships of the fluoroquinolones Antimicrob. Agents Chemother. 33, 131-135 (Pubitemid 19053845)