Indexed keywords
DRUG;
COMBINATORIAL CHEMISTRY;
COMPUTER MODEL;
DRUG INDUSTRY;
DRUG RESEARCH;
GENE SEQUENCE;
GENOMICS;
HIGH THROUGHPUT SCREENING;
HUMAN;
HYDROPHOBICITY;
LIPOPHILICITY;
MOLECULAR RECOGNITION;
REVIEW;
SIGNAL TRANSDUCTION;
STATISTICS;
ANIMALS;
COMBINATORIAL CHEMISTRY TECHNIQUES;
DRUG DISCOVERY;
DRUG EVALUATION, PRECLINICAL;
DRUG INDUSTRY;
EFFICIENCY, ORGANIZATIONAL;
GENOMICS;
HIGH-THROUGHPUT SCREENING ASSAYS;
HUMANS;
MODELS, ORGANIZATIONAL;
MOLECULAR TARGETED THERAPY;
RESEARCH DESIGN;
1
13844276627
Target-based drug discovery: Is something wrong?
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2
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Binding site detection and druggability from frst principles
Seco J, Luque FJ, Barril X: Binding site detection and druggability from frst principles. J Med Chem (2009) 52(8) 2363-2371.
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J Med Chem , vol.52
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Luque, F.J.2
Barril, X.3
3
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Druggable pockets and binding site centric chemical space: A paradigm shift in drug discovery
Pérot S, Sperandio O, Miteva MA, Camproux AC, Villoutreix BO: Druggable pockets and binding site centric chemical space: A paradigm shift in drug discovery. Drug Disc Today (2010) 15(15/16):656-667.
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Drug Disc Today , vol.15
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Pérot, S.1
Sperandio, O.2
Miteva, M.A.3
Camproux, A.C.4
Villoutreix, B.O.5
4
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Druggability indices for protein targets derived from NMr-based screening data
DOI 10.1021/jm049131r
Hadjuk PJ, Huth JR, Fesik SW: Druggability indices for protein targets derived from NMR-based screening data. J Med Chem (2005) 48(7):2518-2525. (Pubitemid 40516441)
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Journal of Medicinal Chemistry , vol.48
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Huth, J.R.2
Fesik, S.W.3
5
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Apparent activity in high-throughput screening: Origins of compound-dependent assay interference
Thorne N, Auld DS, Inglese J: Apparent activity in high-throughput screening: Origins of compound-dependent assay interference. Curr Opin Chem Bio (2010) 14(3):315-324.
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Curr Opin Chem Bio , vol.14
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Thorne, N.1
Auld, D.S.2
Inglese, J.3
6
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Chemical space and biology
DOI 10.1038/nature03192
Dobson CM: Chemical space and biology. Nature (2004) 432(7019):824-828. (Pubitemid 40037137)
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7
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Fragment screening: An introduction
Leach AR, Hann MM, Burrows JN, Griffen EJ: Fragment screening: An introduction. Mol Biosyst (2006) 2(9):429-446.
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Mol Biosyst , vol.2
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Leach, A.R.1
Hann, M.M.2
Burrows, J.N.3
Griffen, E.J.4
8
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Recent developments in fragment-based drug discovery
DOI 10.1021/jm8000373
Congreve M, Chessari G, Tisi D, Woodhead AJ: Recent developments in fragment-based drug discovery. J Med Chem (2008) 51(13):3661-3680. (Pubitemid 351956496)
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Journal of Medicinal Chemistry , vol.51
, Issue.13
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Congreve, M.1
Chessari, G.2
Tisi, D.3
Woodhead, A.J.4
9
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Lessons from 60 years of pharmaceutical innovation
Munos B: Lessons from 60 years of pharmaceutical innovation. Nat Drug Disc (2009) 8(12):959-968.
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Nat Drug Disc , vol.8
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Munos, B.1
