Determination of platelet-bound glycoprotein-specific autoantibodies by flow cytometric immunobead assay in primary immune thrombocytopenia

European Journal of Haematology

Volumn 86, Issue 4, 2011, Pages 339-346

  Liu, Xin Guang ^a   Li, Jin Lin ^b   Qin, Ping ^a   Ren, Juan ^a   Ma, Shi Hui ^c   Sun, Lin ^a   Shi, Yan ^a   Ji, Xue Bin ^a   Zhu, Yuan Yuan ^a   Ma, Dao Xin ^a   Guo, Cheng Shan ^d   Du, Xin ^e   Hou, Ming ^a,f   Peng, Jun ^a,f  

^a SHANDONG UNIVERSITY   (China)

^b Shenzhen University School of Medicine   (China)

^c INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

^d SHANDONG UNIVERSITY   (China)

^e Shenzhen Second Hospital   (China)

^f Qilu Hospital of Shandong University   (China)

Author keywords

Autoantibody; Flow cytometry; Glycoprotein; Microbead; Primary immune thrombocytopenia

Indexed keywords

FIBRINOGEN RECEPTOR; THROMBIN RECEPTOR;

ADULT; ANTIBODY DETECTION; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; FEMALE; FLOW CYTOMETRY; FLOW CYTOMETRY IMMUNOBEAD ASSAY; FLUORESCENCE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNOASSAY; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MONOCLONAL ANTIBODY SPECIFIC IMMOBILIZATION OF PLATELET ANTIGEN; MULTICENTER STUDY; PRIMARY IMMUNE THROMBOCYTOPENIA; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

ADOLESCENT; ADULT; ANTIBODY SPECIFICITY; ANTIGENS, HUMAN PLATELET; AUTOANTIBODIES; BLOOD PLATELETS; CASE-CONTROL STUDIES; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOASSAY; MALE; MIDDLE AGED; PLATELET MEMBRANE GLYCOPROTEINS; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; YOUNG ADULT;

EID: 79952758003     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2010.01572.x     Document Type: Article

References (29)

1. Berchtold P, Wenger M. Autoantibodies against platelet glycoproteins in autoimmune thrombocytopenic purpura: their clinical significance and response to treatment. Blood 1993;81:1246-50.
2. Kuwana M, Kaburaki J, Ikeda Y. Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura: role in production of anti-platelet autoantibody. J Clin Invest 1998;102:1393-402.
3. Kelton JG. The serological investigation of patients with autoimmune thrombocytopenia. Thromb Haemost 1995;74:228-33.
4. Lazarchick J, Hall SA. Platelet-associated IgG assay using flow cytometric analysis. J Immunol Methods 1986;87:257-65.
5. Kelton JG, Murphy WG, Lucarelli A, Garvey-Williams J, Santos A, Meyer R, Powers P. A prospective comparison of four techniques for measuring platelet-associated IgG. Br J Haematol 1989;71:97-105.
6. Warner M, Kelton JG. Laboratory investigation of immune thrombocytopenia. J Clin Pathol 1997;50:5-12.
7. George JN, Woolf SH, Raskob GE, et al. Idiopathic thrombocytopenia purpura: a practice guideline developed by explicit methods for the American Society of Hematology. Blood 1996;88:3-40.
8. Kiefel V, Santoso S, Weisheit M, Mueller-Eckhardt C. Monoclonal antibody-specific immobilization of platelet antigens (MAIPA). A new tool for the identification of platelet-reactive antibodies. Blood 1987;70:1722-6.
9. McMillan R, Tani P, Millard F, Berchtold P, Renshaw L, Woods VL. Platelet-associated and plasma anti-glycoprotein autoantibodies in chronic ITP. Blood 1987;70:1040-5.
10. Brighton TA, Evan S, Castaldi PA, Chesterman CN, Chong BH. Prospective evaluation of the clinical usefulness of an antigen-specific assay (MAIPA) in idiopathic thrombocytopenic purpura and other immune thrombocytopenias. Blood 1996;88:194-201.
11. Chong BH, Ho SJ. Autoimmune thrombocytopenia. J Thromb Haemost 2005;3:1763-72.
12. McMillan R. Antigen-specific assays in immune thrombocytopenia. Transfus Med Rev 1990;4:136-43.
13. Provan D, Stasi R, Newland AC, et al. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood 2010;115:168-86.
14. Woods VL, Oh EH, Mason D, McMillan R. Autoantibodies against the platelet glycoprotein IIb/IIIa complex in patients with chronic ITP. Blood 1984;63:368-75.
15. Kiefel V, Santoso S, Kaufmann E, Mueller-Eckhardt C. Autoantibodies against glycoprotein Ib/IX: a frequent finding in autoimmune thrombocytopenic purpura. Br J Haematol 1991;79:256-62.
16. Berchtold P, Müller D, Beardsley D, et al. International study to compare antigen-specific methods used for the measurement of antiplatelet autoantibodies. Br J Haematol 1997;96:477-83.
17. Tomer A, Koziol J, McMillan R. Autoimmune thrombocytopenia: flow cytometric determination of platelet-associated autoantibodies against platelet-specific receptors. J Thromb Haemost 2005;3:74-8.
18. Hou M, Peng J, Shi Y, Zhang C, Qin P, Zhao C, Ji X, Wang X, Zhang M. Mycophenolate mofetil (MMF) for the treatment of steroid-resistant idiopathic thrombocytopenic purpura. Eur J Haematol 2003;70:353-7.
19. Fujisawa K, Tani P, Piro L, McMillan R. The effect of therapy on platelet-associated autoantibody in chronic immune thrombocytopenic purpura. Blood 1993;81:2872-7.
20. Chong BH, Keng TB. Advances in the diagnosis of idiopathic thrombocytopenic purpura. Semin Hematol 2000;37:249-60.
21. McMillan R, Wang L, Tani P. Prospective evaluation of the immunobead assay for the diagnosis of immune thrombocytopenic purpura (ITP). J Thromb Haemost 2003;1:485-91.
22. British Committee for Standards in Haematology General Haematology Task Force. Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy. Br J Haematol 2003;120:574-96.
23. Kuwana M, Kurata Y, Fujimura K, Fujisawa K, Wada H, Nagasawa T, Nomura S, Kojima T, Yagi H, Ikeda Y. Preliminary laboratory based diagnostic criteria for immune thrombocytopenic purpura: evaluation by multi-center prospective study. J Thromb Haemost 2006;4:1936-43.
24. Fabris F, Scandellari R, Ruzzon E, Randi ML, Luzzatto G, Girolami A. Platelet-associated autoantibodies as detected by a solid-phase modified antigen ELISA test (MACE) are a useful prognostic factor in idiopathic thrombocytopenic purpura. Blood 2004;103:4562-4.
25. Tomer A. Flow cytometry for the diagnosis of autoimmune thrombocytopenia. Curr Hematol Rep 2006;5:64-9.
26. Olsson A, Andersson PO, Tengborn L, Wadenvik H. Serum from patients with chronic idiopathic thrombocytopenic purpura frequently affect the platelet function. Thromb Res 2002;107:135-9.
27. Chu XX, Hou M, Peng J, Zhu YY, Ji XB, Wang L, Zhang F, Ma DX. Effects of IgG and its F(ab')2 fragments of some patients with idiopathic thrombocytopenic purpura on platelet aggregation. Eur J Haematol 2006;76:153-9.
28. Warner MN, Moore JC, Warkentin TE, Santos AV, Kelton JG. A prospective study of protein-specific assays used to investigate idiopathic thrombocytopenic purpura. Br J Haematol 1999;104:442-7.
29. Olsson B, Andersson PO, Jernås M, Jacobsson S, Carlsson B, Carlsson LM, Wadenvik H. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med 2003;9:1123-4.