-
2
-
-
0030934862
-
Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma- associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis
-
Bischof D, Pulford K, Mason DY, Morris SW. (1997). Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis. Mol Cell Biol 17: 2312-2325. (Pubitemid 27133318)
-
(1997)
Molecular and Cellular Biology
, vol.17
, Issue.4
, pp. 2312-2325
-
-
Bischof, D.1
Pulford, K.2
Mason, D.Y.3
Morris, S.W.4
-
3
-
-
10044276783
-
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
-
DOI 10.1101/gad.1256804
-
Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E et al. (2004). Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev 18: 2893-2904. (Pubitemid 39602308)
-
(2004)
Genes and Development
, vol.18
, Issue.23
, pp. 2893-2904
-
-
Brugarolas, J.1
Lei, K.2
Hurley, R.L.3
Manning, B.D.4
Reiling, J.H.5
Hafen, E.6
Witters, L.A.7
Ellisen, L.W.8
Kaelin Jr., W.G.9
-
4
-
-
0037372285
-
NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors
-
DOI 10.1182/blood-2002-05-1343
-
Chiarle R, Gong JZ, Guasparri I, Pesci A, Cai J, Liu J et al. (2003). NPM-ALK transgenic mice spontaneously develop T-cell lympho-mas and plasma cell tumors. Blood 101: 1919-1927. (Pubitemid 36237594)
-
(2003)
Blood
, vol.101
, Issue.5
, pp. 1919-1927
-
-
Chiarle, R.1
Gong, J.Z.2
Guasparri, I.3
Pesci, A.4
Cai, J.5
Liu, J.6
Simmons, W.J.7
Dhall, G.8
Howes, J.9
Piva, R.10
Inghirami, G.11
-
5
-
-
37549057005
-
The anaplastic lymphoma kinase in the pathogenesis of cancer
-
Chiarle R, Voena C, Ambrogio C, Piva R, Inghirami G. (2008). The anaplastic lymphoma kinase in the pathogenesis of cancer. Nat Rev Cancer 8: 11-23.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 11-23
-
-
Chiarle, R.1
Voena, C.2
Ambrogio, C.3
Piva, R.4
Inghirami, G.5
-
6
-
-
0030003813
-
Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)
-
DOI 10.1073/pnas.93.9.4181
-
Fujimoto J, Shiota M, Iwahara T, Seki N, Satoh H, Mori S et al. (1996). Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t (2; 5). Proc Natl Acad Sci USA 93: 4181-4186. (Pubitemid 26146730)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.9
, pp. 4181-4186
-
-
Fujimoto, J.1
Shiota, M.2
Iwahara, T.3
Seki, N.4
Satoh, H.5
Mori, S.6
Yamamoto, T.7
-
7
-
-
43449116075
-
Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family
-
DOI 10.1111/j.1365-2141.2008.07093.x
-
Evens AM, Schumacker PT, Helenowski IB, Singh AT, Dokic D, Keswani A et al. (2008). Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family. Br J Haematol 141: 676-680. (Pubitemid 351667626)
-
(2008)
British Journal of Haematology
, vol.141
, Issue.5
, pp. 676-680
-
-
Evens, A.M.1
Schumacker, P.T.2
Helenowski, I.B.3
Singh, A.T.K.4
Dokic, D.5
Keswani, A.6
Kordeluk, E.7
Raji, A.8
Winter, J.N.9
Jovanovic, B.D.10
Holmgren, A.11
Nelson, B.P.12
Gordon, L.I.13
-
8
-
-
33846110366
-
Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK
-
DOI 10.1073/pnas.0609412103
-
Galkin AV, Melnick JS, Kim S, Hood TL, Li N, Li L et al. (2007). Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc Natl Acad Sci USA 104: 270-275. (Pubitemid 46068021)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.1
, pp. 270-275
-
-
Galkin, A.V.1
Melnick, J.S.2
Kim, S.3
Hood, T.L.4
Li, N.5
Li, L.6
Xia, G.7
Steensma, R.8
Chopiuk, G.9
Jiang, J.10
Wan, Y.11
Ding, P.12
Liu, Y.13
Sun, F.14
Schultz, P.G.15
Gray, N.S.16
Warmuth, M.17
-
9
-
-
58949086093
-
Phosphorylated VEGFR2/KDR receptors are widely expressed in B-cell non-Hodgkin's lymphomas and correlate with hypoxia inducible factor activation
-
Giatromanolaki A, Koukourakis MI, Pezzella F, Sivridis E, Turley H, Harris AL et al. (2008). Phosphorylated VEGFR2/KDR receptors are widely expressed in B-cell non-Hodgkin's lymphomas and correlate with hypoxia inducible factor activation. Hematol Oncol 26: 219-224.
-
(2008)
Hematol Oncol
, vol.26
, pp. 219-224
-
-
Giatromanolaki, A.1
Koukourakis, M.I.2
Pezzella, F.3
Sivridis, E.4
Turley, H.5
Harris, A.L.6
-
10
-
-
33745587303
-
Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3
-
DOI 10.1073/pnas.0603507103
-
Kasprzycka M, Marzec M, Liu X, Zhang Q, Wasik MA. (2006). Nucleophosmin/ anaplastic lymphoma kinase (NPM/ALK) onco-protein induces the T regulatory cell phenotype by activating STAT3. Proc Natl Acad Sci USA 103: 9964-9969. (Pubitemid 43993606)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.26
, pp. 9964-9969
-
-
Kasprzycka, M.1
Marzec, M.2
Liu, X.3
Zhang, Q.4
Wasik, M.A.5
-
11
-
-
0030809095
-
Retrovirus-mediated gene transfer of NPM-ALK causes lymphoid malignancy in mice
-
Kuefer MU, Look AT, Pulford K, Behm FG, Pattengale PK, Mason DY et al. (1997). Retrovirus-mediated gene transfer of NPM-ALK causes lymphoid malignancy in mice. Blood 90: 2901-2910. (Pubitemid 27444183)
-
(1997)
Blood
, vol.90
, Issue.8
, pp. 2901-2910
-
-
Kuefer, M.U.1
Look, A.T.2
Pulford, K.3
Behm, F.G.4
Pattengale, P.K.5
Mason, D.Y.6
Morris, S.W.7
-
12
-
-
42549119526
-
Development of anaplastic lymphoma kinase (ALK) small-molecule inhibitors for cancer therapy
-
DOI 10.1002/med.20109
-
Li R, Morris SW. (2008). Development of anaplastic lymphoma kinase (ALK) small-molecule inhibitors for cancer therapy. Med Res Rev 28: 372-412. (Pubitemid 351590540)
-
(2008)
Medicinal Research Reviews
, vol.28
, Issue.3
, pp. 372-412
-
-
Li, R.1
Morris, S.W.2
-
13
-
-
16844368861
-
Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice
-
DOI 10.1158/0008-5472.CAN-04-2425
-
Ling X, Arlinghaus RB. (2005). Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice. Cancer Res 65: 2532-2536. (Pubitemid 40490046)
-
(2005)
Cancer Research
, vol.65
, Issue.7
, pp. 2532-2536
-
-
Ling, X.1
Arlinghaus, R.B.2
-
14
-
-
65449136761
-
ALK mutants in the kinase domain exhibit altered kinase activity and differential sensitivity to small molecule ALK inhibitors
-
Lu L, Ghose AK, Quail MR, Albom MS, Durkin JT, Holskin BP et al. (2009). ALK mutants in the kinase domain exhibit altered kinase activity and differential sensitivity to small molecule ALK inhibitors. Biochemistry 48: 3600-3609.
-
(2009)
Biochemistry
, vol.48
, pp. 3600-3609
-
-
Lu, L.1
Ghose, A.K.2
Quail, M.R.3
Albom, M.S.4
Durkin, J.T.5
Holskin, B.P.6
-
15
-
-
34547935219
-
Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway
-
DOI 10.1038/sj.onc.1210346, PII 1210346
-
Marzec M, Kasprzycka M, Liu X, El-Salem M, Halasa K, Raghunath PN et al. (2007). Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway. Oncogene 26: 5606-5614. (Pubitemid 47267838)
-
(2007)
Oncogene
, vol.26
, Issue.38
, pp. 5606-5614
-
-
Marzec, M.1
Kasprzycka, M.2
Liu, X.3
El-Salem, M.4
Halasa, K.5
Raghunath, P.N.6
Bucki, R.7
Wlodarski, P.8
Wasik, M.A.9
-
16
-
-
27944485366
-
Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3
-
DOI 10.1038/labinvest.3700348, PII 3700348
-
Marzec M, Kasprzycka M, Ptasznik A, Wlodarski P, Zhang Q, Odum N et al. (2005). Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3. Lab Invest 85: 1544-1554. (Pubitemid 41662338)
-
(2005)
Laboratory Investigation
, vol.85
, Issue.12
, pp. 1544-1554
-
-
Marzec, M.1
Kasprzycka, M.2
Ptasznik, A.3
Wlodarski, P.4
Zhang, Q.5
Odum, N.6
Wasik, M.A.7
-
17
-
-
58549102319
-
Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-LI, B7-H1)
-
Marzec M, Zhang Q, Goradia A, Raghunath PN, Liu X, Paessler M et al. (2008). Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-LI, B7-H1). Pro Natl Acad Sci USA 105: 20852-20857.
-
(2008)
Pro Natl Acad Sci USA
, vol.105
, pp. 20852-20857
-
-
Marzec, M.1
Zhang, Q.2
Goradia, A.3
Raghunath, P.N.4
Liu, X.5
Paessler, M.6
-
18
-
-
0028198206
-
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
-
Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL et al. (1994). Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 263: 1281-1284. (Pubitemid 24107549)
-
(1994)
Science
, vol.263
, Issue.5151
, pp. 1281-1284
-
-
Morris, S.W.1
Kirstein, M.N.2
Valentine, M.B.3
Dittmer, K.G.4
Shapiro, D.N.5
Saltman, D.L.6
Look, A.T.7
-
19
-
-
0031008896
-
ALK the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
-
Morris SW, Naeve C, Mathew P, James PL, Kirstein MN, Cui X et al. (1997). ALK, the chromosome 2 gene locus altered by the t (2; 5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). Oncogene 14: 2175-2188. (Pubitemid 27248229)
-
(1997)
Oncogene
, vol.14
, Issue.18
, pp. 2175-2188
-
-
Morris, S.W.1
Naeve, C.2
Mathew, P.3
James, P.L.4
Kirstein, M.N.5
Cui, X.6
Witte, D.P.7
-
20
-
-
51649096739
-
Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells
-
Niu G, Briggs J, Deng J, Ma Y, Lee H, Kortylewski M et al. (2008). Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells. Mol Cancer Res 6: 1099-1105.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 1099-1105
-
-
Niu, G.1
Briggs, J.2
Deng, J.3
Ma, Y.4
Lee, H.5
Kortylewski, M.6
-
21
-
-
57249089043
-
Histological expression of angiogenic factors: VEGF, PDGFRalpha, and HIF-1alpha in Hodgkin lymphoma
-
Passam FH, Alexandrakis MG, Kafousi M, Fotinou M, Darivianaki K, Tsirakis G et al. (2009). Histological expression of angiogenic factors: VEGF, PDGFRalpha, and HIF-1alpha in Hodgkin lymphoma. Pathol Res Pract 205: 11-20.
-
(2009)
Pathol Res Pract
, vol.205
, pp. 11-20
-
-
Passam, F.H.1
Alexandrakis, M.G.2
Kafousi, M.3
Fotinou, M.4
Darivianaki, K.5
Tsirakis, G.6
-
22
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. (2003). Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732. (Pubitemid 37328811)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.10
, pp. 721-732
-
-
Semenza, G.L.1
-
23
-
-
0028275645
-
Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3
-
Shiota M, Fujimoto J, Semba T, Satoh H, Yamamoto T, Mori S. (1994). Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, S3. Oncogene 9: 1567-1574. (Pubitemid 24163381)
-
(1994)
Oncogene
, vol.9
, Issue.6
, pp. 1567-1574
-
-
Shiota, M.1
Fujimoto, J.2
Semba, T.3
Satoh, H.4
Yamamoto, T.5
Mori, S.6
-
24
-
-
64849103123
-
Anaplastic lymphoma kinase (ALK)-induced malignancies: Novel mechanisms of cell transformation and potential therapeutic approaches
-
Wasik MA, Zhang Q, Marzec M, Kasprzycka M, Wang HY, Liu X. (2009). Anaplastic lymphoma kinase (ALK)-induced malignancies: novel mechanisms of cell transformation and potential therapeutic approaches. Semin Oncol 36: 27-35.
-
(2009)
Semin Oncol
, vol.36
, pp. 27-35
-
-
Wasik, M.A.1
Zhang, Q.2
Marzec, M.3
Kasprzycka, M.4
Wang, H.Y.5
Liu, X.6
-
25
-
-
58149380071
-
The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappaB-dependent transcription
-
Wright CW, Duckett CS. (2009). The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappaB-dependent transcription. Science 323: 251-255.
-
(2009)
Science
, vol.323
, pp. 251-255
-
-
Wright, C.W.1
Duckett, C.S.2
-
26
-
-
1042302005
-
The stats of cancer - New molecular targets come of age
-
Yu H, Jove R. (2004). The STATs of cancer-new molecular targets come of age. Nat Rev Cancer 4: 97-105. (Pubitemid 38198738)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.2
, pp. 97-105
-
-
Yu, H.1
Jove, R.2
-
27
-
-
64849111865
-
Targeting STAT3 in cancer: How successful are we?
-
Yue P, Turkson J. (2009). Targeting STAT3 in cancer: how successful are we? Expert Opin Investig Drugs 18: 45-56.
-
(2009)
Expert Opin Investig Drugs
, vol.18
, pp. 45-56
-
-
Yue, P.1
Turkson, J.2
-
28
-
-
0036134884
-
Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma
-
Zhang Q, Raghunath PN, Xue L, Majewski M, Carpentieri DF, Odum N et al. (2002). Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma. J Immunol 168: 466-474. (Pubitemid 34014150)
-
(2002)
Journal of Immunology
, vol.168
, Issue.1
, pp. 466-474
-
-
Zhang, Q.1
Raghunath, P.N.2
Xue, L.3
Majewski, M.4
Carpentieri, D.F.5
Odum, N.6
Morris, S.7
Skorski, T.8
Wasik, M.A.9
-
29
-
-
35948966315
-
STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression
-
DOI 10.1038/nm1659, PII NM1659
-
Zhang Q, Wang HY, Liu X, Wasik MA. (2007). STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression. Nat Med 13: 1341-1348. (Pubitemid 350073594)
-
(2007)
Nature Medicine
, vol.13
, Issue.11
, pp. 1341-1348
-
-
Zhang, Q.1
Wang, H.Y.2
Liu, X.3
Wasik, M.A.4
|