메뉴 건너뛰기




Volumn 6, Issue 3, 2011, Pages

Cooperative nuclear localization sequences lend a novel role to the N-terminal region of MSH6

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MSH2; PROTEIN MSH6; DNA BINDING PROTEIN; G T MISMATCH BINDING PROTEIN; G-T MISMATCH-BINDING PROTEIN; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN;

EID: 79952749904     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017907     Document Type: Article
Times cited : (22)

References (48)
  • 1
    • 33750083332 scopus 로고    scopus 로고
    • Mechanisms in eukaryotic mismatch repair
    • Modrich P, (2006) Mechanisms in eukaryotic mismatch repair. J Biol Chem 281: 30305-30309.
    • (2006) J Biol Chem , vol.281 , pp. 30305-30309
    • Modrich, P.1
  • 3
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg R, (2000) The hallmarks of cancer. Cell 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.2
  • 4
    • 0034500024 scopus 로고    scopus 로고
    • DNA mismatch repair and genetic instability
    • Harfe B, Jinks-Robertson S, (2000) DNA mismatch repair and genetic instability. Annu Rev Genet 34: 359-399.
    • (2000) Annu Rev Genet , vol.34 , pp. 359-399
    • Harfe, B.1    Jinks-Robertson, S.2
  • 7
    • 0033764146 scopus 로고    scopus 로고
    • Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complex
    • Flores-Rozas H, Clark D, Kolodner RD, (2000) Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complex. Nature Genetics 26: 375-378.
    • (2000) Nature Genetics , vol.26 , pp. 375-378
    • Flores-Rozas, H.1    Clark, D.2    Kolodner, R.D.3
  • 9
    • 0035868951 scopus 로고    scopus 로고
    • hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci
    • Kleczkowska HE, Marra G, Lettieri T, Jiricny J, (2001) hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci. Genes & Development 15: 724-736.
    • (2001) Genes & Development , vol.15 , pp. 724-736
    • Kleczkowska, H.E.1    Marra, G.2    Lettieri, T.3    Jiricny, J.4
  • 10
    • 34248579736 scopus 로고    scopus 로고
    • The N terminus of Saccharomyces cerevisiale Msh6 is an unstructured tether to PCNA
    • Shell SS, Putnam CD, Kolodner RD, (2007) The N terminus of Saccharomyces cerevisiale Msh6 is an unstructured tether to PCNA. Molecular Cell 26: 565-578.
    • (2007) Molecular Cell , vol.26 , pp. 565-578
    • Shell, S.S.1    Putnam, C.D.2    Kolodner, R.D.3
  • 11
    • 45149112792 scopus 로고    scopus 로고
    • The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair
    • Iyer R, Pohlhaus T, Chen S, Hura G, Dzantiev L, et al. (2008) The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair. J Biol Chem 283: 13310-13319.
    • (2008) J Biol Chem , vol.283 , pp. 13310-13319
    • Iyer, R.1    Pohlhaus, T.2    Chen, S.3    Hura, G.4    Dzantiev, L.5
  • 12
    • 44949248392 scopus 로고    scopus 로고
    • Human mismatch repair protein MSH6 contains a PWWP domain that targets double stranded DNA
    • Laguri C, Duband-Goulet I, Friedrich N, Axt M, Belin P, et al. (2008) Human mismatch repair protein MSH6 contains a PWWP domain that targets double stranded DNA. Biochemistry 47: 6199-6207.
    • (2008) Biochemistry , vol.47 , pp. 6199-6207
    • Laguri, C.1    Duband-Goulet, I.2    Friedrich, N.3    Axt, M.4    Belin, P.5
  • 13
    • 65649091344 scopus 로고    scopus 로고
    • Reciprocal regulation of nuclear import of the yeast MutS[alpha] DNA mismatch repair proteins Msh2 and Msh6
    • Hayes AP, Sevi LA, Feldt MC, Rose MD, Gammie AE, (2009) Reciprocal regulation of nuclear import of the yeast MutS[alpha] DNA mismatch repair proteins Msh2 and Msh6. DNA Repair 8: 739-751.
    • (2009) DNA Repair , vol.8 , pp. 739-751
    • Hayes, A.P.1    Sevi, L.A.2    Feldt, M.C.3    Rose, M.D.4    Gammie, A.E.5
  • 14
    • 68849118239 scopus 로고    scopus 로고
    • Nuclear import of human MLH1, PMS2, and MutLalpha: redundancy is the key
    • Leong V, Lorenowicz J, Kozij N, Guarné A, (2009) Nuclear import of human MLH1, PMS2, and MutLalpha: redundancy is the key. Mol Carcinog 48: 742-750.
    • (2009) Mol Carcinog , vol.48 , pp. 742-750
    • Leong, V.1    Lorenowicz, J.2    Kozij, N.3    Guarné, A.4
  • 16
    • 0034680776 scopus 로고    scopus 로고
    • Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents
    • Christmann M, Kaina B, (2000) Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents. Journal of Biological Chemistry 275: 36256-36262.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 36256-36262
    • Christmann, M.1    Kaina, B.2
  • 17
    • 0036567603 scopus 로고    scopus 로고
    • Phosphorylation of mismatch repair proteins MSH2 and MSH6 affecting MutS alpha mismatch-binding activity
    • Christmann M, Tomicic MT, Kaina B, (2002) Phosphorylation of mismatch repair proteins MSH2 and MSH6 affecting MutS alpha mismatch-binding activity. Nucleic Acids Research 30: 1959-1966.
    • (2002) Nucleic Acids Research , vol.30 , pp. 1959-1966
    • Christmann, M.1    Tomicic, M.T.2    Kaina, B.3
  • 18
    • 75149143337 scopus 로고    scopus 로고
    • Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage
    • Mastrocola A, Heinen C, (2010) Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage. DNA Repair (Amst) 9: 120-133.
    • (2010) DNA Repair (Amst) , vol.9 , pp. 120-133
    • Mastrocola, A.1    Heinen, C.2
  • 19
    • 55449088400 scopus 로고    scopus 로고
    • Recruitment of mismatch repair proteins to the site of DNA damage in human cells
    • Hong Z, Jiang J, Hashiguchi K, Hoshi M, Lan L, et al. (2008) Recruitment of mismatch repair proteins to the site of DNA damage in human cells. Journal of Cell Science 121: 3146-3154.
    • (2008) Journal of Cell Science , vol.121 , pp. 3146-3154
    • Hong, Z.1    Jiang, J.2    Hashiguchi, K.3    Hoshi, M.4    Lan, L.5
  • 20
    • 34247135913 scopus 로고    scopus 로고
    • Classical nuclear localization signals: definition, function, and interaction with importin alpha
    • Lange A, Mills R, Lange C, Stewart M, Devine S, et al. (2007) Classical nuclear localization signals: definition, function, and interaction with importin alpha. J Biol Chem 282: 5101-5105.
    • (2007) J Biol Chem , vol.282 , pp. 5101-5105
    • Lange, A.1    Mills, R.2    Lange, C.3    Stewart, M.4    Devine, S.5
  • 22
    • 58649104919 scopus 로고    scopus 로고
    • Six classes of nuclear localization signals specific to different binding grooves of importin alpha
    • Kosugi S, Hasebe M, Matsumura N, Takashima H, Miyamoto-Sato E, et al. (2009) Six classes of nuclear localization signals specific to different binding grooves of importin alpha. J Biol Chem 284: 478-485.
    • (2009) J Biol Chem , vol.284 , pp. 478-485
    • Kosugi, S.1    Hasebe, M.2    Matsumura, N.3    Takashima, H.4    Miyamoto-Sato, E.5
  • 23
    • 0030776227 scopus 로고    scopus 로고
    • Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6
    • Umar A, Koi M, Risinger J, Glaab W, Tindall K, et al. (1997) Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6. Cancer Res 57: 3949-3955.
    • (1997) Cancer Res , vol.57 , pp. 3949-3955
    • Umar, A.1    Koi, M.2    Risinger, J.3    Glaab, W.4    Tindall, K.5
  • 24
    • 0026078249 scopus 로고
    • Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence
    • Robbins J, Dilworth S, Laskey R, Dingwall C, (1991) Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence. Cell 64: 615-623.
    • (1991) Cell , vol.64 , pp. 615-623
    • Robbins, J.1    Dilworth, S.2    Laskey, R.3    Dingwall, C.4
  • 25
    • 0028784167 scopus 로고
    • Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines
    • Boyer J, Umar A, Risinger J, Lipford J, Kane M, et al. (1995) Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. Cancer Res 55: 6063-6070.
    • (1995) Cancer Res , vol.55 , pp. 6063-6070
    • Boyer, J.1    Umar, A.2    Risinger, J.3    Lipford, J.4    Kane, M.5
  • 26
    • 0027234076 scopus 로고
    • Use of a general purpose mammalian expression vector for studying intracellular protein targeting: identification of critical residues in the nuclear lamin A/C nuclear localization signal
    • Frangioni J, Neel B, (1993) Use of a general purpose mammalian expression vector for studying intracellular protein targeting: identification of critical residues in the nuclear lamin A/C nuclear localization signal. J Cell Sci 105 (Pt 2): 481-488.
    • (1993) J Cell Sci , vol.105 , Issue.Pt 2 , pp. 481-488
    • Frangioni, J.1    Neel, B.2
  • 27
    • 0032749569 scopus 로고    scopus 로고
    • Germ-line msh6 mutations in colorectal cancer families
    • Kolodner R, Tytell J, Schmeits J, Kane M, Gupta R, et al. (1999) Germ-line msh6 mutations in colorectal cancer families. Cancer Res 59: 5068-5074.
    • (1999) Cancer Res , vol.59 , pp. 5068-5074
    • Kolodner, R.1    Tytell, J.2    Schmeits, J.3    Kane, M.4    Gupta, R.5
  • 28
    • 57649112528 scopus 로고    scopus 로고
    • Hereditary cancer-associated missense mutations in hMSH6 uncouple ATP hydrolysis from DNA mismatch binding
    • Cyr J, Heinen C, (2008) Hereditary cancer-associated missense mutations in hMSH6 uncouple ATP hydrolysis from DNA mismatch binding. J Biol Chem 283: 31641-31648.
    • (2008) J Biol Chem , vol.283 , pp. 31641-31648
    • Cyr, J.1    Heinen, C.2
  • 29
    • 0023731952 scopus 로고
    • Identification of the human c-myc protein nuclear translocation signal
    • Dang C, Lee W, (1988) Identification of the human c-myc protein nuclear translocation signal. Mol Cell Biol 8: 4048-4054.
    • (1988) Mol Cell Biol , vol.8 , pp. 4048-4054
    • Dang, C.1    Lee, W.2
  • 30
    • 0030221192 scopus 로고    scopus 로고
    • Comparative mutagenesis of nuclear localization signals reveals the importance of neutral and acidic amino acids
    • Makkerh J, Dingwall C, Laskey R, (1996) Comparative mutagenesis of nuclear localization signals reveals the importance of neutral and acidic amino acids. Curr Biol 6: 1025-1027.
    • (1996) Curr Biol , vol.6 , pp. 1025-1027
    • Makkerh, J.1    Dingwall, C.2    Laskey, R.3
  • 31
    • 0024820410 scopus 로고
    • Characterisation of the nuclear location sequence of Xenopus nucleoplasmin
    • Dingwall C, Robbins J, Dilworth S, (1989) Characterisation of the nuclear location sequence of Xenopus nucleoplasmin. J Cell Sci Suppl 11: 243-248.
    • (1989) J Cell Sci Suppl , vol.11 , pp. 243-248
    • Dingwall, C.1    Robbins, J.2    Dilworth, S.3
  • 32
    • 0034696798 scopus 로고    scopus 로고
    • The homeodomain of Nkx2.2 carries two cooperatively acting nuclear localization signals
    • Hessabi B, Schmidt I, Walther R, (2000) The homeodomain of Nkx2.2 carries two cooperatively acting nuclear localization signals. Biochem Biophys Res Commun 270: 695-700.
    • (2000) Biochem Biophys Res Commun , vol.270 , pp. 695-700
    • Hessabi, B.1    Schmidt, I.2    Walther, R.3
  • 33
    • 0025021189 scopus 로고
    • Characterization of nuclear localizing sequences derived from yeast ribosomal protein L29
    • Underwood M, Fried H, (1990) Characterization of nuclear localizing sequences derived from yeast ribosomal protein L29. EMBO J 9: 91-99.
    • (1990) EMBO J , vol.9 , pp. 91-99
    • Underwood, M.1    Fried, H.2
  • 34
    • 0022546215 scopus 로고
    • Nuclear location signals in polyoma virus large-T
    • Richardson W, Roberts B, Smith A, (1986) Nuclear location signals in polyoma virus large-T. Cell 44: 77-85.
    • (1986) Cell , vol.44 , pp. 77-85
    • Richardson, W.1    Roberts, B.2    Smith, A.3
  • 35
    • 0141680841 scopus 로고    scopus 로고
    • TBX5 nuclear localization is mediated by dual cooperative intramolecular signals
    • Collavoli A, Hatcher C, He J, Okin D, Deo R, et al. (2003) TBX5 nuclear localization is mediated by dual cooperative intramolecular signals. J Mol Cell Cardiol 35: 1191-1195.
    • (2003) J Mol Cell Cardiol , vol.35 , pp. 1191-1195
    • Collavoli, A.1    Hatcher, C.2    He, J.3    Okin, D.4    Deo, R.5
  • 36
    • 69949136451 scopus 로고    scopus 로고
    • A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers
    • Mehta T, Lu H, Wang X, Urvalek A, Nguyen K, et al. (2009) A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers. Cell Res 19: 1098-1109.
    • (2009) Cell Res , vol.19 , pp. 1098-1109
    • Mehta, T.1    Lu, H.2    Wang, X.3    Urvalek, A.4    Nguyen, K.5
  • 37
    • 0033047314 scopus 로고    scopus 로고
    • Characterization of regions functional in the nuclear localization of the Fanconi anemia group A protein
    • Lightfoot J, Alon N, Bosnoyan-Collins L, Buchwald M, (1999) Characterization of regions functional in the nuclear localization of the Fanconi anemia group A protein. Hum Mol Genet 8: 1007-1015.
    • (1999) Hum Mol Genet , vol.8 , pp. 1007-1015
    • Lightfoot, J.1    Alon, N.2    Bosnoyan-Collins, L.3    Buchwald, M.4
  • 38
    • 0032748328 scopus 로고    scopus 로고
    • Nuclear localization conferred by the pocket domain of the retinoblastoma gene product
    • Zacksenhaus E, Jiang Z, Hei Y, Phillips R, Gallie B, (1999) Nuclear localization conferred by the pocket domain of the retinoblastoma gene product. Biochim Biophys Acta 1451: 288-296.
    • (1999) Biochim Biophys Acta , vol.1451 , pp. 288-296
    • Zacksenhaus, E.1    Jiang, Z.2    Hei, Y.3    Phillips, R.4    Gallie, B.5
  • 39
    • 34447264031 scopus 로고    scopus 로고
    • A new variant database for mismatch repair genes associated with Lynch syndrome
    • Woods M, Williams P, Careen A, Edwards L, Bartlett S, et al. (2007) A new variant database for mismatch repair genes associated with Lynch syndrome. Hum Mutat 28: 669-673.
    • (2007) Hum Mutat , vol.28 , pp. 669-673
    • Woods, M.1    Williams, P.2    Careen, A.3    Edwards, L.4    Bartlett, S.5
  • 40
    • 0025848680 scopus 로고
    • The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)
    • Vasen H, Mecklin J, Khan P, Lynch H, (1991) The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Rectum 34: 424-425.
    • (1991) Dis Colon Rectum , vol.34 , pp. 424-425
    • Vasen, H.1    Mecklin, J.2    Khan, P.3    Lynch, H.4
  • 41
    • 0001628596 scopus 로고    scopus 로고
    • Familial endometrial cancer in female carriers of MSH6 germline mutations
    • Wijnen J, de Leeuw W, Vasen H, van der Klift H, Møller P, et al. (1999) Familial endometrial cancer in female carriers of MSH6 germline mutations. Nat Genet 23: 142-144.
    • (1999) Nat Genet , vol.23 , pp. 142-144
    • Wijnen, J.1    de Leeuw, W.2    Vasen, H.3    van der Klift, H.4    Møller, P.5
  • 42
    • 77952305131 scopus 로고    scopus 로고
    • Constitutional mismatch repair deficiency and childhood leukemia/lymphoma - report on a novel biallelic MSH6 mutation
    • Ripperger T, Beger C, Rahner N, Sykora K, Bockmeyer C, et al. (2010) Constitutional mismatch repair deficiency and childhood leukemia/lymphoma- report on a novel biallelic MSH6 mutation. Haematologica 95: 841-844.
    • (2010) Haematologica , vol.95 , pp. 841-844
    • Ripperger, T.1    Beger, C.2    Rahner, N.3    Sykora, K.4    Bockmeyer, C.5
  • 43
    • 5144220638 scopus 로고    scopus 로고
    • Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility
    • Yang G, Scherer SJ, Shell SS, Yang K, Kim M, et al. (2004) Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility. Cancer Cell 6: 139-150.
    • (2004) Cancer Cell , vol.6 , pp. 139-150
    • Yang, G.1    Scherer, S.J.2    Shell, S.S.3    Yang, K.4    Kim, M.5
  • 44
    • 23244452266 scopus 로고    scopus 로고
    • Functional significance and clinical phenotype of nontruncating mismatch repair variants of MLH1
    • Raevaara T, Korhonen M, Lohi H, Hampel H, Lynch E, et al. (2005) Functional significance and clinical phenotype of nontruncating mismatch repair variants of MLH1. Gastroenterology 129: 537-549.
    • (2005) Gastroenterology , vol.129 , pp. 537-549
    • Raevaara, T.1    Korhonen, M.2    Lohi, H.3    Hampel, H.4    Lynch, E.5
  • 45
    • 55549138787 scopus 로고    scopus 로고
    • MSH2 missense mutations and HNPCC syndrome: pathogenicity assessment in a human expression system
    • Belvederesi L, Bianchi F, Galizia E, Loretelli C, Bracci R, et al. (2008) MSH2 missense mutations and HNPCC syndrome: pathogenicity assessment in a human expression system. Hum Mutat 29: E296-309.
    • (2008) Hum Mutat , vol.29
    • Belvederesi, L.1    Bianchi, F.2    Galizia, E.3    Loretelli, C.4    Bracci, R.5
  • 46
    • 34248525914 scopus 로고    scopus 로고
    • Quantitative fluorescence microscopy and image deconvolution
    • Swedlow JR, (2007) Quantitative fluorescence microscopy and image deconvolution. Methods Cell Biol 81: 447-465.
    • (2007) Methods Cell Biol , vol.81 , pp. 447-465
    • Swedlow, J.R.1
  • 48
    • 0030739712 scopus 로고    scopus 로고
    • A general computational framework for modeling cellular structure and function
    • Schaff J, Fink CC, Slepchenko B, Carson JH, Loew LM, (1997) A general computational framework for modeling cellular structure and function. Biophys J 73: 1135-1146.
    • (1997) Biophys J , vol.73 , pp. 1135-1146
    • Schaff, J.1    Fink, C.C.2    Slepchenko, B.3    Carson, J.H.4    Loew, L.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.