Phencyclidine false positive induced by lamotrigine (Lamictal®) on a rapid urine toxicology screen

International Journal of Emergency Medicine

Volumn 3, Issue 4, 2010, Pages 327-331

  Geraci, Matthew J ^a   Peele, James ^a   McCoy, Stacey L ^a   Elias, Brad ^a  

^a BAPTIST MEDICAL CENTER   (United States)

Author keywords

Drugs of abuse; False positive; Lamotrigine (lamictal); Phencyclidine (PCP); Rapid urine drug screen; Toxicology

Indexed keywords

ALPRAZOLAM; CLONAZEPAM; DOCUSATE SODIUM; ETODOLAC; FLUOXETINE; LAMOTRIGINE; METHADONE; OXCARBAZEPINE; OXYCODONE; OXYMORPHONE; PHENCYCLIDINE; POTASSIUM CHLORIDE; PREGABALIN; ROSUVASTATIN; TEMAZEPAM; TOPIRAMATE; TRAMADOL;

ABNORMAL LABORATORY RESULT; ADULT; ANTICONVULSANT THERAPY; ARTICLE; BEDTIME DOSAGE; CASE REPORT; DEPRESSION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG SCREENING; FALSE POSITIVE RESULT; FEMALE; HUMAN; MALE; NARCOTIC DEPENDENCE; PRIORITY JOURNAL; PSYCHOSIS; SEIZURE; SIDE EFFECT; URINALYSIS;

EID: 79952736852     PISSN: 18651372     EISSN: 18651380     Source Type: Journal    
DOI: 10.1007/s12245-010-0235-3     Document Type: Article

References (20)

1. KrasowskiM, Pizon A, SiamMet al (2009) Using molecular similarity to highlight the challenges of routine immunoassay-based drug of abuse/toxicology screening in emergency medicine. BMC Emerg Med 9(1):5
2. Lacy C, Armstrong L, GoldmanMet al (eds) (2008) Lexi-comp drug database drug information handbook, 17th edn. Lexi-Comp Information Management Service (LIMS), Hudson, OH, pp 885-887
3. Jacob MS, Carlen PL, Marshman JA et al (1981) Phencyclidine ingestion: drug abuse and psychosis. Int J Addict 16(4):749-758 (Pubitemid 11017655)
4. Yago KB, Pitts FN Jr, Burgoyne RW et al (1981) The urban epidemic of phencyclidine (PCP) use: Clinical and laboratory evidence from a public psychiatric hospital emergency service. J Clin Psychiatry 42(5):193-196 (Pubitemid 11107568)
5. Bio-Rad Laboratories (2009) TOX/See drug screen test package insert. Number: 1155895805
6. Alexander KL (2009) "Scary Drug" Makes Comeback - As PCP Use Rebounds Among Suspects, DC. Authorities Worry About Violent Incidents. Washington Post. (http://www.washingtonpost.com/wp-dyn/content/article/2009/03/ 16/AR2009031603178.html) Accessed: 2/9/2010, Published: 3/17/2009
7. Johnston LD, O'Malley PM, Bachman JG et al. Monitoring the future, national results on adolescent drug use: Overview of key findings, 2008. The University of Michigan Institute for Social Research 2009;NIH Publication No. 09-7401 (http://www.monitoringthefuture.org/) Accessed: 2/9/2010
8. Moeller KE, Lee KC, Kissack JC (2008) Urine drug screening: practical guide for clinicians. Mayo Clin Proc 83(1):66-76
9. Department of Health and Human Services (DHHS) Substance Abuse Mental Health Services Administration (SAMSHA) http://workplace.samhsa.gov/DrugTesting/ RegGuidance/UrineConcen.aspx. Accessed: 2/9/2010
10. Vogl WF (2004) Federal Register: Mandatory Guidelines and Proposed Revisions to Mandatory Guidelines for Federal Workplace Drug Testing Programs; Notices. DHHS - SAMSHA. 69(71)
11. Santos PM, Lopez-Garcia P, Navarro JS et al (2007) False positive phencyclidine results caused by venlafaxine. Am J Psychiatry 164 (2):349
12. Schier J, Díaz JE (2000) Avoid unfavorable consequences: dextromethorphan can bring about a false-positive phencyclidine urine drug screen. J Emerg Med 18(3):379-381 (Pubitemid 30154082)
13. Schwartz RH (2005) Adolescent abuse of dextromethorphan. Clin Pediatr 44(7):565-568
14. Sena SF, Kazimi S, Wu AHB (2002) False-positive phencyclidine immunoassay results caused by venlafaxine and Odesmethylvenlafaxine. Clin Chem 48(4):676-677 (Pubitemid 34261241)
15. Bond GR, Steele PE, Uges DRA (2003) Massive venlafaxine overdose resulted in a false positive abbott AxSYMA urine immunoassay for phencyclidine. Clin Toxicol 41(7):999-1002 (Pubitemid 38018494)
16. Budai B, Iskandar H (2002) Dextromethorphan can produce false positive phencyclidine testing with HPLC. Am J Emerg Med 20 (1):61-62 (Pubitemid 34052524)
17. Romanelli F, Smith KM (2009) Dextromethorphan abuse: clinical effects and management. J Am Pharm Assoc (2003) 49(2):20-25
18. Collins GB, McAllister MS (2008) Chloroquine psychosis masquerading as PCP: a case report. J Psychoactive Drugs 40(2):211-214
19. Hull M, Griggs D, Knoepp S et al (2006) Postmortem urine immunoassay showing false-positive phencyclidine reactivity in a case of fatal tramadol overdose. Am J Forensic Med Pathol 27 (4):359-362 (Pubitemid 44875897)
20. Bio-Rad Laboratories (2007) TOX/See urine drug screen tests technical information - troubleshooting guide crossreactivity tables. 18