Differential disposition of intra-renal generated and preformed glucuronides: Studies with 4-methylumbelliferone and 4-methylumbelliferyl glucuronide in the filtering and nonfiltering isolated perfused rat kidney

Journal of Pharmacy and Pharmacology

Volumn 63, Issue 4, 2011, Pages 507-514

  Wang, Jiping ^a   Evans, Allan M ^a   Knights, Kathleen M ^b   Miners, John O ^b  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^b FLINDERS UNIVERSITY   (Australia)

Author keywords

4 methylumbelliferone; Glucuronidation; Isolated perfused rat kidney; Pharmacokinetics; Preformed glucuronide

Indexed keywords

DRUG METABOLITE; HYMECROMONE GLUCURONIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG DISPOSITION; DRUG EXCRETION; DRUG GLUCURONIDATION; DRUG HALF LIFE; GLOMERULUS FILTRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; ISOLATED KIDNEY; KIDNEY CLEARANCE; KIDNEY PERFUSION; KIDNEY TUBULE ABSORPTION; MALE; METABOLIC CLEARANCE RATE; NONHUMAN; RAT;

ANIMALS; HALF-LIFE; HYMECROMONE; KIDNEY; MALE; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 79952717177     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2010.01244.x     Document Type: Article

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