Is There a Benefit to Extending the Duration of Helicobacter pylori Sequential Therapy to 14 Days?

Helicobacter

Volumn 16, Issue 2, 2011, Pages 146-152

  Hsu, Ping I ^a   Wu, Deng Chyang ^b   Wu, Jeng Yih ^b,c   Graham, David Y ^d  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c KAOHSIUNG MUNICIPAL HSIAO KANG HOSPITAL   (Taiwan)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Amoxicillin; Clarithromycin; Clinical trial; Helicobacter pylori; Metronidazole.; Proton pump inhibitor; Sequential therapy

Indexed keywords

ALUMINUM MAGNESIUM HYDROXIDE; AMOXICILLIN; CLARITHROMYCIN; ESOMEPRAZOLE; LEDERSCON; METRONIDAZOLE; NONSTEROID ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG; UREA; UREASE;

ABDOMINAL PAIN; ADULT; AGE; ALCOHOL CONSUMPTION; ANOREXIA; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIUM CULTURE; BREATH ANALYSIS; CHEMOTHERAPY INDUCED EMESIS; COFFEE; COMBINATION CHEMOTHERAPY; CONSTIPATION; DIARRHEA; DIZZINESS; DRUG EFFICACY; DRUG ERUPTION; DRUG INDUCED HEADACHE; DRUG WITHDRAWAL; DUODENUM ULCER; DYSPEPSIA; ERADICATION THERAPY; FATIGUE; FEMALE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; PATIENT COMPLIANCE; PEPTIC ULCER; PRIORITY JOURNAL; SEX; SINGLE BLIND PROCEDURE; SMOKING; STOMACH ULCER; TASTE DISORDER; TEA; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT;

AGED; AMOXICILLIN; ANTI-BACTERIAL AGENTS; CLARITHROMYCIN; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; HELICOBACTER INFECTIONS; HUMANS; MALE; METRONIDAZOLE; MIDDLE AGED; PROTON PUMP INHIBITORS; TREATMENT OUTCOME;

HELICOBACTER PYLORI;

EID: 79952716248     PISSN: 10834389     EISSN: 15235378     Source Type: Journal    
DOI: 10.1111/j.1523-5378.2011.00829.x     Document Type: Article

References (25)

1. Chey WD, Wong BC. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol 2007;102:1808-25.
2. Malfertheiner P, Megraud F, O'Morain C, Bazzoli F, el-Omar E, Graham D, Hunt R, Rokkas T, Vakil N, Kuipers EJ. Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut 2007;56:772-81.
3. Graham DY, Fischbach L. Helicobacter pylori treatment in the era of increasing antibiotic resistance. Gut 2010;59:1143-53.
4. Horiki N, Omata F, Uemura M, et al. Annual change of primary resistance to clarithromycin among Helicobacter pylori isolates from 1996 through 2008 in Japan. Helicobacter 2009;14:86-90.
5. Megraud F. H pylori antibiotic resistance: prevalence, importance, and advances in testing. Gut 2004;53:1374-84.
6. Gatta L, Vakil N, Leandro G, Di MF, Vaira D. Sequential therapy or triple therapy for Helicobacter pylori infection: systematic review and meta-analysis of randomized controlled trials in adults and children. Am J Gastroenterol 2009;104:3069-79.
7. Gisbert JP, Calvet X, O'connor A, Megraud F, O'Morain CA. Sequential therapy for Helicobacter pylori eradication: a critical review. J Clin Gastroenterol 2010;44:313-25.
8. Graham DY, Lu H, Yamaoka Y. A report card to grade Helicobacter pylori therapy. Helicobacter 2007;12:275-8.
9. Graham DY, Shiotani A. New concepts of resistance in the treatment of Helicobacter pylori infections. Nat Clin Pract Gastroenterol Hepatol 2008;5:321-31.
10. Graham DY, Lu H, Yamaoka Y. Therapy for Helicobacter pylori infection can be improved: sequential therapy and beyond. Drugs 2008;68:725-36.
11. Graham DY. Helicobacter pylori eradication therapy research: ethical issues and description of results. Clin Gastroenterol Hepatol 2010;8:1032-6.
12. Wu DC, Hsu PI, Wu JY, Opekun AR, Kuo CH, Wu IC, Wang SS, Chen A, Hung WC, Graham DY. Sequential and concomitant therapy with 4 drugs are equally effective for eradication of H. pylori infection. Clin Gastroenterol Hepatol 2010;8:36-41.
13. Graham DY. Efficient Identification and Evaluation of Effective Helicobacter pylori Therapies. Clin Gastroenterol Hepatol 2009;7:145-8.
14. Graham DY. Therapy of Helicobacter pylori: current status and issues. Gastroenterology 2000;118:S2-8.
15. Hsu PI, Wu DC, Wu JY, Graham DY. Modified sequential H. pylori therapy: PPI and amoxicillin for 14 days with clarithromycin and metronidazole added as a quadruple (hybrid) therapy for the final 7 days. Helicobacter 2011;16:139-45.
16. Hsu PI, Lai KH, Wu CJ, Tseng HH, Tsay FW, Peng NJ, Chen TA, Chuah SK, Lin WS, Lo GH. High-dose versus low-dose esomeprazole-based triple therapy for Helicobacter pylori infection. Eur J Clin Invest 2007;37:724-30.
17. Hsu PI, Lai KH, Tseng HH, et al. Correlation of serum immunoglobulin G Helicobacter pylori antibody titers with histologic and endoscopic findings in patients with dyspepsia. J Clin Gastroenterol 1997;25:587-91.
18. Peng NJ, Lai KH, Liu RS, Lee SC, Tsay DG, Lo CC, Tseng HH, Huang WK, Lo GH, Hsu PI. Clinical significance of oral urease in diagnosis of Helicobacter pylori infection by [13C]urea breath test. Dig Dis Sci 2001;46:1772-8.
19. Hsu PI, Hwang IR, Cittelly D, Lai KH, El Zimaity HM, Gutierrez O, Kim JG, Osato MS, Graham DY, Yamaoka Y. Clinical presentation in relation to diversity within the Helicobacter pylori cag pathogenicity island. Am J Gastroenterol 2002;97:2231-8.
20. Kuo CH, Hu HM, Kuo FC, et al. Efficacy of levofloxacin-based rescue therapy for Helicobacter pylori infection after standard triple therapy: a randomized controlled trial. J Antimicrob Chemother 2009;63:1017-24.
21. Hollis S, Campbell F. What is meant by intention to treat analysis? Survey of published randomised controlled trials. BMJ 1999;319:670-4.
22. Zullo A, De Francesco V, Hassan C, Morini S, Vaira D. The sequential therapy regimen for Helicobacter pylori eradication: a pooled-data analysis. Gut 2007;56:1353-7.
23. Broutet N, Tchamgoue S, Pereira E, Lamouliatte H, Salamon R, Megraud F. Risk factors for failure of Helicobacter pylori therapy - results of an individual data analysis of 2751 patients. Aliment Pharmacol Ther 2003;17:99-109.
24. Zullo A, Perna F, Hassan C, Ricci C, Saracino I, Morini S, Vaira D. Primary antibiotic resistance in Helicobacter pylori strains isolated in northern and central Italy. Aliment Pharmacol Ther 2007;25:1429-34.
25. Taneike I, Nami A, O'connor A, Fitzgerald N, Murphy P, Qasim A, O'Connor H, O'Morain C. Analysis of drug resistance and virulence-factor genotype of Irish Helicobacter pylori strains: is there any relationship between resistance to metronidazole and cagA status? Aliment Pharmacol Ther 2009;30:784-90.