Down-regulation of keratin 4 and keratin 13 expression in oral squamous cell carcinoma and epithelial dysplasia: A clue for histopathogenesis

Histopathology

Volumn 58, Issue 4, 2011, Pages 531-542

  Sakamoto, Kei ^a   Aragaki, Tadanobu ^a   Morita, Kei ichi ^a   Kawachi, Hiroshi ^a   Kayamori, Kou ^a   Nakanishi, Shoichi ^a   Omura, Ken ^a   Miki, Yoshio ^a,b   Okada, Norihiko ^a   Katsube, Ken ichi ^a   Takizawa, Toichiro ^a   Yamaguchi, Akira ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b CANCER INSTITUTE   (Japan)

Author keywords

Cytokeratin; Epithelial dysplasia; Keratin; Keratin 13; Keratin 4; Oral mucosa; Squamous cell carcinoma

Indexed keywords

COMPLEMENTARY DNA; CYTOKERATIN; CYTOKERATIN 1; CYTOKERATIN 10; CYTOKERATIN 13; CYTOKERATIN 14; CYTOKERATIN 15; CYTOKERATIN 16; CYTOKERATIN 17; CYTOKERATIN 18; CYTOKERATIN 19; CYTOKERATIN 2; CYTOKERATIN 20; CYTOKERATIN 4; CYTOKERATIN 5; CYTOKERATIN 6; CYTOKERATIN 6B; CYTOKERATIN 7; CYTOKERATIN 71; CYTOKERATIN 72; CYTOKERATIN 73; CYTOKERATIN 74; CYTOKERATIN 75; CYTOKERATIN 76; CYTOKERATIN 77; CYTOKERATIN 78; CYTOKERATIN 79; CYTOKERATIN 8; CYTOKERATIN 80; CYTOKERATIN 9; UNCLASSIFIED DRUG;

ARTICLE; CANCER DIAGNOSIS; CANCER MORPHOLOGY; CELL MOTION; CELL SHAPE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; EPITHELIUM DYSPLASIA; GENETIC TRANSFECTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MALE; MOUTH CARCINOMA; MOUTH EPITHELIUM DYSPLASIA; MOUTH MUCOSA; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA;

BIOPSY; CARCINOMA, SQUAMOUS CELL; CELL LINE; CLONING, MOLECULAR; DOWN-REGULATION; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; KERATIN-13; KERATIN-4; MALE; MOUTH MUCOSA; MOUTH NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 79952713629     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2011.03759.x     Document Type: Article

References (27)

1. Moll R, Divo M, Langbein L. The human keratins: biology and pathology. Histochem. Cell Biol. 2008; 129; 705-733.
2. Crowe DL, Milo GE, Shuler CF. Keratin 19 downregulation by oral squamous cell carcinoma lines increases invasive potential. J. Dent. Res. 1999; 78; 1256-1263.
3. Farrar M, Sandison A, Peston D, Gailani M. Immunocytochemical analysis of AE1/AE3, CK 14, Ki-67 and p53 expression in benign, premalignant and malignant oral tissue to establish putative markers for progression of oral carcinoma. Br. J. Biomed. Sci. 2004; 61; 117-124.
4. Fillies T, Werkmeister R, Packeisen J et al. Cytokeratin 8/18 expression indicates a poor prognosis in squamous cell carcinomas of the oral cavity. BMC Cancer 2006; 6; 10.
5. Gires O, Mack B, Rauch J, Matthias C. CK8 correlates with malignancy in leukoplakia and carcinomas of the head and neck. Biochem. Biophys. Res. Commun. 2006; 343; 252-259.
6. Matthias C, Mack B, Berghaus A, Gires O. Keratin 8 expression in head and neck epithelia. BMC Cancer 2008; 8; 267.
7. Ogden GR, Lane EB, Hopwood DV, Chisholm DM. Evidence for field change in oral cancer based on cytokeratin expression. Br. J. Cancer 1993; 67; 1324-1330.
8. Ohkura S, Kondoh N, Hada A et al. Differential expression of the keratin-4, -13, -14, -17 and transglutaminase 3 genes during the development of oral squamous cell carcinoma from leukoplakia. Oral Oncol. 2005; 41; 607-613.
9. Su L, Morgan PR, Lane EB. Keratin 14 and 19 expression in normal, dysplastic and malignant oral epithelia. A study using in situ hybridization and immunohistochemistry. J. Oral Pathol. Med. 1996; 25; 293-301.
10. Toyoshima T, Vairaktaris E, Nkenke E, Schlegel KA, Neukam FW, Ries J. Cytokeratin 17 mRNA expression has potential for diagnostic marker of oral squamous cell carcinoma. J. Cancer Res. Clin. Oncol. 2008; 134; 515-521.
11. Xu XC, Lee JS, Lippman SM, Ro JY, Hong WK, Lotan R. Increased expression of cytokeratins CK8 and CK19 is associated with head and neck carcinogenesis. Cancer Epidemiol. Biomarkers Prev. 1995; 4; 871-876.
12. Yanagawa T, Yoshida H, Yamagata K et al. Loss of cytokeratin 13 expression in squamous cell carcinoma of the tongue is a possible sign for local recurrence. J. Exp. Clin. Cancer Res. 2007; 26; 215-220.
13. Zhong LP, Chen WT, Zhang CP, Zhang ZY. Increased CK19 expression correlated with pathologic differentiation grade and prognosis in oral squamous cell carcinoma patients. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2007; 104; 377-384.
14. Depondt J, Shabana AH, Sawaf H, Gehanno P, Forest N. Cytokeratin alterations as diagnostic and prognostic markers of oral and pharyngeal carcinomas. A prospective study. Eur. J. Oral Sci. 1999; 107; 442-454.
15. Fillies T, Jogschies M, Kleinheinz J, Brandt B, Joos U, Buerger H. Cytokeratin alteration in oral leukoplakia and oral squamous cell carcinoma. Oncol. Rep. 2007; 18; 639-643.
16. Ogden GR, Chisholm DM, Adi M, Lane EB. Cytokeratin expression in oral cancer and its relationship to tumor differentiation. J. Oral Pathol. Med. 1993; 22; 82-86.
17. Vaidya MM, Borges AM, Pradhan SA, Bhisey AN. Cytokeratin expression in squamous cell carcinomas of the tongue and alveolar mucosa. Eur. J. Cancer B Oral Oncol. 1996; 32B; 333-336.
18. Barnes L, Eveson J, Reichart P, Sidransky D. Epithelial precursor lesions. World Health Organization classification of tumours. Pathology and genetics. Head and neck tumours. Geneva, Switzerland: WHO Press, 2005; 177-180.
19. Tomioka H, Morita K, Hasegawa S, Omura K. Gene expression analysis by cDNA microarray in oral squamous cell carcinoma. J. Oral Pathol. Med. 2006; 35; 206-211.
20. Bonifacino JS, Dasso M, Harford JB, Lippincott-Schwartz J, Yamada KM. Current protocols in cell biology. Hoboken, NJ, USA: John Wiley and Sons, Inc., 2007.
21. Su L, Morgan PR, Lane EB. Protein and mRNA expression of simple epithelial keratins in normal, dysplastic, and malignant oral epithelia. Am. J. Pathol. 1994; 145; 1349-1357.
22. Zhong LP, Zhao SF, Chen GF, Ping FY, Xu ZF, Hu JA. Increased levels of CK19 mRNA in oral squamous cell carcinoma tissue detected by relative quantification with real-time polymerase chain reaction. Arch. Oral Biol. 2006; 51; 1112-1119.
23. Richard G, De Laurenzi V, Didona B, Bale SJ, Compton JG. Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus. Nat. Genet. 1995; 11; 453-455.
24. Rugg EL, McLean WH, Allison WE et al. A mutation in the mucosal keratin K4 is associated with oral white sponge nevus. Nat. Genet. 1995; 11; 450-452.
25. Ness SL, Edelmann W, Jenkins TD, Liedtke W, Rustgi AK, Kucherlapati R. Mouse keratin 4 is necessary for internal epithelial integrity. J. Biol. Chem. 1998; 273; 23904-23911.
26. Mazzalupo S, Wong P, Martin P, Coulombe PA. Role for keratins 6 and 17 during wound closure in embryonic mouse skin. Dev. Dyn. 2003; 226; 356-365.
27. Wawersik M, Coulombe PA. Forced expression of keratin 16 alters the adhesion, differentiation, and migration of mouse skin keratinocytes. Mol. Biol. Cell 2000; 11; 3315-3327.