The association between Lymphogranuloma venereum and HIV among men who have sex with men: Systematic review and meta-analysis

BMC Infectious Diseases

Volumn 11, Issue , 2011, Pages

  Rönn, Minttu M ^a   Ward, Helen ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CASE CONTROL STUDY; CHLAMYDIASIS; DESCRIPTIVE RESEARCH; DISEASE ASSOCIATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; LYMPHOGRANULOMA VENEREUM; MALE; MALE HOMOSEXUAL; PREVALENCE; RECTUM; SYSTEMATIC REVIEW; COMORBIDITY; HOMOSEXUALITY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; META ANALYSIS;

COMORBIDITY; HIV INFECTIONS; HOMOSEXUALITY, MALE; HUMANS; LYMPHOGRANULOMA VENEREUM; MALE; PREVALENCE;

EID: 79952701043     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-11-70     Document Type: Article

References (67)

1. Thomson NR, Holden MTG, Carder C, Lennard N, Lockey SJ, Marsh P, Skipp P, O'Connor CD, Goodhead I, Norbertzcak H, et al. Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates. Genome Research 2008, 18(1):161-171. 10.1101/gr.7020108, 2134780, 18032721.
2. Schachter J, Stephens RS. Biology of Chlamydia trachomatis. Sexually Transmitted Diseases 2008, 555-574. The McGraw-Hill Companies, Holmes KK, Sparling PF, Stamm WE, Piot P, Wasserheit JN, Corey L, Cohen MS, Watts C, 4.
3. Pannekoek Y, Morelli G, Kusecek B, Morre SA, Ossewaarde JM, Langerak AA, van der Ende A. Multi locus sequence typing of Chlamydiales: clonal groupings within the obligate intracellular bacteria Chlamydia trachomatis. BMC Microbiol 2008, 8:42. 10.1186/1471-2180-8-42, 2268939, 18307777.
4. Stamm WE. Lymphogranuloma venereum. Sexually Transmitted Diseases 2008, 595-605. The McGraw-Hill Companies, Holmes KK, Sparling PF, Stamm WE, Piot P, Wasserheit JN, Corey L, Cohen MS, Watts DH, 4.
5. Götz H, Nieuwenhuis R, Ossewaarde T, Bing Thio H, van der Meijden W, Dees J, de Zwart O. Preliminary report of an outbreak of lymphogranuloma venereum in homosexual men in the Netherlands, with implications for other countries in western Europe. Euro Surveill 2004, 8(4).
6. Liassine N, Caulfield A, Ory G, Restellini A, de Barbeyrac B, Sitavanc R, Descombes MC, Luescher D. First confirmed case of lymphogranuloma venereum (LGV) in Switzerland. Euro Surveill 2005, 10(7). E050714.050714.
7. Berglund T, Bratt G, Herrmann B, Karlsson A, Lofdahl M, Payne L. Two cases of lymphogranuloma venereum (LGV) in homosexual men in Stockholm. Euro Surveill 2005, 10(3). E050303.050303.
8. Plettenberg A, von Krosigk A, Stoehr A, Meyer T. Four cases of lymphogranuloma venereum in Hamburg, 2003. Euro Surveill 2004, 8(30).
9. Vall Mayans M, Sanz Colomo B, Ossewaarde JM. First case of LGV confirmed in Barcelona. Euro Surveill 2005, 10(2). E050203.050202.
10. von Holsterin I, Fenton AF, Ison C. European network for surveillance of STIs (ESSTI) establishes working groups on lymphogranuloma venereum and HIV/STI prevention among MSM. Euro Surveill 2004, 8(25).
11. Ahdoot A, Kotler DP, Suh JS, Kutler C, Flamholz R. Lymphogranuloma venereum in human immunodeficiency virus-infected individuals in New York City. J Clin Gastroenterol 2006, 40(5):385-390. 10.1097/00004836-200605000-00005, 16721218.
12. Kropp RY, Wong T, Canadian LGVWG. Emergence of lymphogranuloma venereum in Canada. CMAJ 2005, 172(13):1674-1676. 1150253, 15928239.
13. Morton AN, Fairley CK, Zaia AM, Chen MY. Anorectal lymphogranuloma venereum in a Melbourne man. Sex Health 2006, 3(3):189-190. 10.1071/SH06029, 17044226.
14. White J. Manifestations and management of lymphogranuloma venereum. Curr Opin Infect Dis 2009, (22):57-66. 10.1097/QCO.0b013e328320a8ae, 19532081.
15. Ward H, Martin I, Macdonald N, Alexander S, Simms I, Fenton K, French P, Dean G, Ison C. Lymphogranuloma venereum in the United kingdom. Clin infect Dis 2007, 44(1):26-32. 10.1086/509922, 17143811.
16. Sethi G, Allason-Jones E, Richens J, Annan NT, Hawkins D, Ekbote A, Alexander S, White J. Lymphogranuloma venereum presenting as genital ulceration and inguinal syndrome in men who have sex with men in London, United Kingdom. Sex Transm Inf 2008, 85(3):165-170.
17. Macdonald N, Ison C, Martin I, Alexander S, Lowndes C, Simms I, Ward H. Initial results of enhanced surveillance for lymphogranuloma venereum (LGV) in England. Euro Surveill 2005, 10(1). E050127.050125.
18. Van der Bij AK, Spaargaren J, Morre SA, Fennema HS, Mindel A, Coutinho RA, de Vries HJ. Diagnostic and clinical implications of anorectal lymphogranuloma venereum in men who have sex with men: a retrospective case-control study. Clin Infect Dis 2006, 42(2):186-194. 10.1086/498904, 16355328.
19. Danta M, Brown D, Bhagani S, Pybus OG, Sabin CA, Nelson M, Fisher M, Johnson AM, Dusheiko GM, et al. Hiv Recent epidemic of acute hepatitis C virus in HIV-positive men who have sex with men linked to high-risk sexual behaviours. AIDS (London, England) 2007, 21(8):983-991. Hiv.
20. Jebbari H, Alexander S, Ward H, Evans B, Solomou M, Thornton A, Dean G, White J, French P, Ison C, et al. Update on lymphogranuloma venereum in the United Kingdom. Sex Transm Inf 2007, 83(4):324-326.
21. van de Laar MJW. The emergence of LGV in western Europe: what do we know, what can we do?. Euro Surveill 2006, 11(9):146-148.
22. Annan NT, Sullivan AK, Nori A, Naydenova P, Alexander S, McKenna A, Azadian B, Mandalia S, Rossi M, Ward H, et al. Rectal chlamydia--a reservoir of undiagnosed infection in men who have sex with men. Sex Transm Inf 2009, 85(3):176-179.
23. Ward H, Alexander S, Carder C, Dean G, French P, Ivens D, Ling C, Paul J, Tong W, White J, et al. The prevalence of lymphogranuloma venereum infection in men who have sex with men: results of a multicentre case finding study. Sex Transm Inf 2009, 85(3):173-175.
24. Ward H, Rönn M. Contribution of sexually transmitted infections to the sexual transmission of HIV. Curr Opin HIV AIDS 2010, 5(4):305-310. 10.1097/COH.0b013e32833a8844, 2923028, 20543605.
25. Rottingen JA, Cameron DW, Garnett GP. A systematic review of the epidemiologic interactions between classic sexually transmitted diseases and HIV: how much really is known?. Sex Transm Dis 2001, 28(10):579-597. 10.1097/00007435-200110000-00005, 11689757.
26. Eurosurveillance. , http://www.eurosurveillance.org/Default.aspx
27. Morre SA, Ouburg S, van Agtmael MA, de Vries HJ. Lymphogranuloma venereum diagnostics: from culture to real-time quadriplex polymerase chain reaction. Sex Transm Inf 2008, 84(4):252-253.
28. Egger M, Davey Smith G, Altman DG. Systematic reviews in health care: meta-analysis in context. 2001, London: BMJ Publishing Group.
29. Kirkwood BR, Sterne JAC. Essential Medical Statistics. 2008, Oxford: Balckwell Science, 2.
30. Petitti DP. Meta-Analysis, Decision Analysis, and Cost-Effectiveness Analysis, Methods for Quantitative Synthesis in Medicine. 2000, New York: Oxford University Press.
31. Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ (Clinical research ed) 2009, 339:b2535. 10.1136/bmj.b2535, 2714657, 19622551.
32. Lymphogranuloma venereum (LGV) in Canada: Recommendations for Diagnosis and Treatment and Protocol for National Enhanced Surveillance. , http://www.phac-aspc.gc.ca/publicat/lgv/lgv-rdt-eng.php
33. Lymphogranuloma Venereum Surveillance - STD information from CDC. , http://www.cdc.gov/std/lgv/stdfact-lgv.htm
34. HPA - Guidelines. , http://www.hpa.org.uk/webw/HPAweb&Page&HPAwebAutoListDate/Page/1191942171553?p = 1191942171553
35. Management of LGV [2006]. , http://www.bashh.org/guidelines
36. Elgalib A, White JA. Observed changes in CD4 count and HIV viral load during lymphogranuloma venereum (LGV) proctitis and non-LGV rectal Chlamydia trachomatis infection among HIV-positive men who have sex with men. Int J STD & AIDS 2007, 18(Supplement 1):26-27. P68.
37. Lymphogranuloma venereum proctitis in Edinburgh, HPS Weekly Report. 2005, http://www.documents.hps.scot.nhs.uk/ewr/pdf2005/0506.pdf
38. Samarawickrama A, Nambiar K, Collins I, Reeves I, Gillian D. Diagnostic utility of rectal microscopy in predicting lymphogranuloma venereum (LGV) in men who have sex with men (MSM): a case control study - Abstract. Sex Transm Inf 2008, 84. e1.P78.B-09.
39. Annan N, Nori A, Naydenova P, McKenna A, Hawkins D, Azadian B, Ison C, Ward H, Sullivan A. Lymphogranuloma venereum (LGV): Clinical Presentation And Treatment Outcomes - Abstract. Sex Transm Inf 2008, 84. e1.P78.B-03.
40. Clark J, Espinosa B, Segundo L, Hall E, Salvatierra H, Caceres C, Klausner J, Coates T. Abscence of Lymphogranuloma Venereum Infection among High-Risk Men Who Have Sex with Men in Lima, Peru - Abstract. Sex Transm Inf 2008, 84. e1.P78.H-01.
41. Saunders P, Ali T, Alexander S, Ison C. Genotyping of Lymphogranuloma venereum LGV in United Kingdom - Abstract. Sex Transm Inf 2008, 84. e1.P78. O-22.
42. Waalboer R, van der Snoek EM, van der Meijden WI, Mulder PGH, Ossewaarde JM. Analysis of rectal Chlamydia trachomatis serovar distribution including L2 (lymphogranuloma venereum) at the Erasmus MC STI clinic, Rotterdam. Sex Transm Inf 2006, 82(3):207-211.
43. Spaargaren J, Schachter J, Moncada J, de Vries HJC, Fennema HSA, Pena AS, Coutinho RA, Morre SA. Slow epidemic of lymphogranuloma venereum L2b strain. Emerg Infect Dis 2005, 11(11):1787-1788.
44. Herida M, Sednaoui P, Couturier E, Neau D, Clerc M, Scieux C, Kreplak G, Goulet V, Hamers FF, de Barbeyrac B. Rectal lymphogranuloma venereum, France. Emerg Infect Dis 2005, 11(3):505-506.
45. Halioua B, Bohbot JM, Monfort L, Nassar N, de Barbeyrac B, Monsonego J, Sednaoui P. Ano-rectal lymphogranuloma venereum: 22 cases reported in a sexually transmited infections center in Paris. Eur J Dermatol 2006, 16(2):177-180.
46. Spaargaren J, Fennema HSA, Morre SA, de Vries HJC, Coutinho RA. New lymphogranuloma venereum Chlamydia trachomatis variant, Amsterdam. Emerg Infect Dis 2005, 11(7):1090-1092.
47. Herida M, de Barbeyrac B, Sednaoui P, Scieux C, Lemarchand N, Kreplak G, Clerc M, Timsit J, Goulet V, Desenclos JC, et al. Rectal lymphogranuloma venereum surveillance in France 2004-2005. Euro Surveill 2006, 11(9):155-156.
48. Pathela P, Blank S, Schillinger JA. Lymphogranuloma venereum: old pathogen, new story. Curr Infect Dis Rep 2007, 9(2):143-150. 10.1007/s11908-007-0010-7, 17324352.
49. van de Laar MJW, Koedijk FDH, Gotz HM, de Vries HJC. A slow epidemic of LGV in the Netherlands in 2004 and 2005. Euro Surveill 2006, 11(9):150-152.
50. Dougan S, Evans BG, Elford J. Sexually transmitted infections in Western Europe among HIV-positive men who have sex with men. Sex Transm Dis 2007, 34(10):783-790.
51. Martin-Iguacel R, Llibre JM, Nielsen H, Heras E, Matas L, Lugo R, Clotet B, Sirera G. Lymphogranuloma venereum proctocolitis: a silent endemic disease in men who have sex with men in industrialised countries. Eur J Clin Microbiol Infect Dis 2010, 29(8):917-925. 10.1007/s10096-010-0959-2, 20509036.
52. Timen A, Hulscher MEJL, Vos D, van de Laar MJW, Fenton KA, van Steenbergen JE, van der Meer JWM, Grol RPTM. Control measures used during lymphogranuloma venereum outbreak, Europe. Emerg Infect Dis 2008, 14(4):573-578. 10.3201/eid1404.061583, 2570903, 18394274.
53. Fenton KA, Imrie J. Increasing rates of sexually transmitted diseases in homosexual men in Western europe and the United States: why?. Infect Dis Clin North Am 2005, 19(2):311-331. 10.1016/j.idc.2005.04.004, 15963874.
54. Ng SC, Gazzard B. Advances in sexually transmitted infections of the gastrointestinal tract. Nat Rev Gastroenterol Hepatol 2009, 6(10):592-607. 10.1038/nrgastro.2009.143, 19707179.
55. Moodley P, Sturm PDJ, Vanmali T, Wilkinson D, Connolly C, Sturm AW. Association between HIV-1 infection, the etiology of genital ulcer disease, and response to syndromic management. Sex Transm Dis 2003, 30(3):241-245. 10.1097/00007435-200303000-00013, 12616144.
56. Bauwens JE, Orlander H, Gomez MP, Lampe M, Morse S, Stamm WE, Cone R, Ashley R, Swenson P, Holmes KK. Epidemic Lymphogranuloma venereum during epidemics of crack cocaine use and HIV infection in the Bahamas. Sex Transm Dis 2002, 29(5):253-259. 10.1097/00007435-200205000-00001, 11984440.
57. Hamill M, Benn P, Carder C, Copas A, Ward H, Ison C, French P. The clinical manifestations of anorectal infection with lymphogranuloma venereum (LGV) versus non-LGV strains of Chlamydia trachomatis: a case-control study in homosexual men. Int J STD & AIDS 2007, 18(7):472-475.
58. van der Snoek EM, Ossewaarde JM, van der Meijden WI, Mulder PGH, Thio HB. The use of serological titres of IgA and IgG in (early) discrimination between rectal infection with non-lymphogranuloma venereum and lymphogranuloma venereum serovars of Chlamydia trachomatis. Sex Transm Inf 2007, 83(4):330-334.
59. McConnell JJ, Bragg L, Shiboski S, Grant RM. Sexual seroadaptation: lessons for prevention and sex research from a cohort of HIV-positive men who have sex with men. PLoS ONE 2010, 5(1):e8831. 10.1371/journal.pone.0008831, 2809110, 20098616.
60. Velicko I, Cullberg M, Bratt G, Mamlov G, Johnsson A, Hansson HB, Herrmann B, Blaxhult A. [Lymphogranuloma venereum--increased spread in Sweden. A rare Chlamydia subtype which become more and more common among men who have sex with men]. Lakartidningen 2009, 106(1-2):28-31.
61. Stary G, Meyer T, Bangert C, Kohrgruber N, Gmeinhart B, Kirnbauer R, Jantschitsch C, Rieger A, Stary A, Geusau A. New Chlamydia trachomatis L2 strains identified in a recent outbreak of lymphogranuloma venereum in Vienna, Austria. Sex Transm Dis 2008, 35(4):377-382. 10.1097/OLQ.0b013e31815d6df8, 18209688.
62. Cusini M, Boneschi V, Arancio L, Ramoni S, Venegoni L, Gaiani F, de Vries H. Lymphogranuloma Venereum: the Italian experience. Sex Transm Inf 2008,
63. Vall Mayans M, Caballero E, Garcia de Olalla P, Armengol P, Codina MG, Barbera MJ, Sanz B, Andreu A, Cayla JA. Outbreak of lymphogranuloma venereum among men who have sex with men in Barcelona 2007/08--an opportunity to debate sexual health at the EuroGames 2008. Euro surveill 2008, 13(25):18908.
64. Stark D, van Hal S, Hillman R, Harkness J, Marriott D. Lymphogranuloma venereum in Australia: anorectal Chlamydia trachomatis serovar L2b in men who have sex with men. J Clin Microbiol 2007, 45(3):1029-1031. 10.1128/JCM.02389-06, 1829134, 17251405.
65. Bremer V, Meyer T, Marcus U, Hamouda O. Lymphogranuloma venereum emerging in men who have sex with men in Germany. Euro Surveill 2006, 11(9):152-154.
66. Gebhardt M, Goldenberger D. Lymphogranuloma venereum (LGV) serotype L2 in Switzerland, 2003-2005. Euro Surveill 2005, 10(12). E051222.051224.
67. de Vries HJC, van der Bij AK, Fennema JSA, Smit C, de Wolf F, Prins M, Coutinho RA, Morre SA. Lymphogranuloma venereum proctitis in men who have sex with men is associated with anal enema use and high-risk behavior. Sex Transm Dis 2008, 35(2):203-208. 10.1097/OLQ.0b013e31815abb08, 18091565.