Stepwise positive association between APOA5 minor allele frequencies and increasing plasma triglyceride quartiles in random patients with hypertriglyceridemia of unclarified origin

Pathology and Oncology Research

Volumn 17, Issue 1, 2011, Pages 39-44

  Hadarits, Ferenc ^a   Kisfali, Péter ^b   Mohás, Márton ^c   Maász, Anita ^b   Sümegi, Katalin ^b   Szabó, Melinda ^d   Hetyésy, Katalin ^e   Valasek, Andrea ^b   Janicsek, Ingrid ^b   Wittmann, István ^c   Melegh, Béla ^b  

^a Markusovszky Teaching Hospital   (Hungary)

^b UNIVERSITY OF PÉCS   (Hungary)

^c UNIVERSITY OF PÉCS   (Hungary)

^d Robert Koch Hospital   (Hungary)

^e Endocrinology and Diabetology   (Hungary)

Author keywords

ApoA5; C56G; Hypertriglyceridemia; IVS3+G476A; PCR RFLP; T 1131C; T1259C

Indexed keywords

ADENINE; CYTOSINE; GUANINE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ISOLEUCINE; SERINE; THYMINE; TRIACYLGLYCEROL; VALINE;

ADULT; APOLIPOPROTEIN A5 GENE; ARTICLE; CHOLESTEROL BLOOD LEVEL; DNA POLYMORPHISM; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; HETEROZYGOTE; HUMAN; HUNGARIAN; HYPERTRIGLYCERIDEMIA; MAJOR CLINICAL STUDY; MALE; RACE; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; AGED; APOLIPOPROTEINS A; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HUNGARY; HYPERTRIGLYCERIDEMIA; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RANDOM ALLOCATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRIGLYCERIDES; YOUNG ADULT;

EID: 79952699420     PISSN: 12194956     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12253-010-9273-7     Document Type: Article

References (30)

1. Charlton M (2009) Obesity, hyperlipidemia, and metabolic syndrome. Liver Transpl 15:S83-S89
2. Karadag MK, Akbulut M (2009) Low HDL levels as the most common metabolic syndrome risk factor in heart failure. Int Heart J 50:571-580
3. Ewald N, Hardt PD, Kloer HU (2009) Severe hypertriglyceridemia and pancreatitis: presentation and management. Curr Opin Lipidol
4. Hopkins PN, Heiss G, Ellison RC et al (2003) Coronary artery disease risk in familial combined hyperlipidemia and familial hypertriglyceridemia: a case-control comparison from the National Heart, Lung, and Blood Institute Family Heart Study. Circulation 108:519-523 (Pubitemid 36961163)
5. St-Pierre J, Lemieux I, Vohl MC et al (2002) Contribution of abdominal obesity and hypertriglyceridemia to impaired fasting glucose and coronary artery disease. Am J Cardiol 90:15-18 (Pubitemid 34671195)
6. Pennacchio LA, Olivier M, Hubacek JA et al (2001) An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science 294:169-173 (Pubitemid 32952971)
7. van der Vliet HN, Sammels MG, Leegwater AC et al (2001) Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration. J Biol Chem 276:44512-44520
8. Baum L, Tomlinson B, Thomas GN (2003) APOA5-1131T>C polymorphism is associated with triglyceride levels in Chinese men. Clin Genet 63:377-379 (Pubitemid 36944080)
9. Hubacek JA, Adamkova V, Ceska R et al (2004) New variants in the apolipoprotein AV gene in individuals with extreme triglyceride levels. Physiol Res 53:225-228 (Pubitemid 38525128)
10. Hubacek JA, Skodova Z, Adamkova V et al (2004) The influence of APOAV polymorphisms (T-1131>C and S19>W) on plasma triglyceride levels and risk of myocardial infarction. Clin Genet 65:126-130 (Pubitemid 38220113)
11. Pennacchio LA, Olivier M, Hubacek JA et al (2002) Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels. Hum Mol Genet 11:3031-3038 (Pubitemid 35414816)
12. Havasi V, Szolnoki Z, Talian G et al (2006) Apolipoprotein A5 gene promoter region T-1131C polymorphism associates with elevated circulating triglyceride levels and confers susceptibility for development of ischemic stroke. J Mol Neurosci 29:177-183 (Pubitemid 44352541)
13. Maasz A, Kisfali P, Jaromi L et al (2008) Apolipoprotein A5 gene IVS3+G476A allelic variant confers susceptibility for development of ischemic stroke. Circ J 72:1065-1070 (Pubitemid 351957070)
14. Maasz A, Kisfali P, Szolnoki Z et al (2008) Apolipoprotein A5 gene C56G variant confers risk for the development of large-vessel associated ischemic stroke. J Neurol 255:649-654
15. Ruiz-Narvaez EA, Yang Y, Nakanishi Y et al (2005) APOC3/A5 haplotypes, lipid levels, and risk of myocardial infarction in the Central Valley of Costa Rica. J Lipid Res 46:2605-2613 (Pubitemid 43107472)
16. Szalai C, Keszei M, Duba J et al (2004) Polymorphism in the promoter region of the apolipoprotein A5 gene is associated with an increased susceptibility for coronary artery disease. Atherosclerosis 173:109-114 (Pubitemid 38224202)
17. Tang Y, Sun P, Guo D et al (2006) A genetic variant c.553G>T in the apolipoprotein A5 gene is associated with an increased risk of coronary artery disease and altered triglyceride levels in a Chinese population. Atherosclerosis 185:433-437
18. Kovar J, Adamkova V (2008) Lipoprotein lipase activity determined in vivo is lower in carriers of apolipoprotein A-V gene variants 19W and -1131C. Physiol Res 57:555-561
19. Merkel M, Heeren J (2005) Give me A5 for lipoprotein hydrolysis! J Clin Invest 115:2694-2696
20. Vaessen SF, Sierts JA, Kuivenhoven JA et al (2009) Efficient lowering of triglyceride levels in mice by human apoAV protein variants associated with hypertriglyceridemia. Biochem Biophys Res Commun 379:542-546
21. Wong-Mauldin K, Raussens V, Forte TM et al (2009) Apolipoprotein A-V N-terminal domain altered lipid interaction properties in vitro explain hypertriglyceridemic phenotype associated with natural truncation mutants. J Biol Chem 284(48):33369-33376
22. Kisfali P, Mohas M, Maasz A et al (2009) Haplotype analysis of the apolipoprotein A5 gene in patients with the metabolic syndrome. Nutr Metab Cardiovasc Dis
23. Ko YL, Ko YS, Wu SM et al (1997) Interaction between obesity and genetic polymorphisms in the apolipoprotein CIII gene and lipoprotein lipase gene on the risk of hypertriglyceridemia in Chinese. Hum Genet 100:327-333
24. Nakanishi N, Nishina K, Okamoto M et al (2004) Clustering of components of the metabolic syndrome and risk for development of type 2 diabetes in Japanese male office workers. Diab Res Clin Pract 63:185-194 (Pubitemid 38142576)
25. Alan S, Ulgen MS, Ozturk O et al (2003) Relation between coronary artery disease, risk factors and intima-media thickness of carotid artery, arterial distensibility, and stiffness index. Angiology 54:261-267 (Pubitemid 36578457)
26. Takase B, Matsushima Y, Uehata A et al (2008) Endothelial dysfunction, carotid artery plaque burden, and conventional exercise-induced myocardial ischemia as predictors of coronary artery disease prognosis. Cardiovasc Ultrasound 6:61
27. Wald DS, Bestwick JP, Morton G et al (2009) Combining carotid intima-media thickness with carotid plaque on screening for coronary heart disease. J Med Screen 16:155-159
28. Eichenbaum-Voline S, Olivier M, Jones EL et al (2004) Linkage and association between distinct variants of the APOA1/C3/A4/ A5 gene cluster and familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol 24:167-174 (Pubitemid 38082429)
29. Liu ZK, Hu M, Baum L et al (2009) Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese. Atherosclerosis 208(2):427-432
30. Wang J, Ban MR, Kennedy BA et al (2008) APOA5 genetic variants are markers for classic hyperlipoproteinemia phenotypes and hypertriglyceridemia. Nat Clin Pract Cardiovasc Med 5:730-737