Evaluation of genotoxicity of Yukmijihwang-tang, a herbal formula

Regulatory Toxicology and Pharmacology

Volumn 59, Issue 3, 2011, Pages 391-396

  Ha, Hyekyung ^a   Lee, Jun Kyoung ^a   Lee, Ho Young ^a   Seo, Chang Seob ^a   Lee, Mee Young ^a   Huh, Jung Im ^b   Shin, Hyeunkyoo ^a  

^a Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^b Korea Institute of Toxicology   (South Korea)

Author keywords

Chromosomal aberration; Herbal formula; Micronucleus test; Reverse mutation; Safety; Yukmijihwang tang

Indexed keywords

ALISMA ORIENTALE EXTRACT; CORNUS OFFICINALIS EXTRACT; CYCLOPHOSPHAMIDE; DIOSCOREA BATATAS EXTRACT; LIUWEIDIHUANG TANG; PAEONIA SUFFRUTICOSA EXTRACT; PLANT EXTRACT; PORIA COCOS EXTRACT; REHMANNIA GLUTINOSA EXTRACT; UNCLASSIFIED DRUG;

AMES TEST; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACTERIUM COLONY; BONE MARROW; CELL STRUCTURE; CHINESE HAMSTER; CHROMOSOME ABERRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DOSE COMPARISON; ERYTHROCYTE; ESCHERICHIA COLI; GENOTOXICITY; LUNG ALVEOLUS CELL; MALE; MICRONUCLEUS; MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; STRAIN DIFFERENCE;

ANIMALS; CELL LINE; CRICETINAE; CRICETULUS; DRUG EVALUATION, PRECLINICAL; DRUGS, CHINESE HERBAL; ERYTHROCYTES; FEMALE; MALE; MICE; MICE, INBRED ICR; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; PLANT PREPARATIONS;

CRICETULUS GRISEUS; ESCHERICHIA COLI; SALMONELLA TYPHIMURIUM;

EID: 79952690811     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2011.01.002     Document Type: Article

References (24)

1. Cheng C.W., Bian Z.X., Wu T.X. Systematic review of Chinese herbal medicine for functional constipation. World J. Gastroenterol. 2009, 15:4886-4895.
2. Dean B.J., Danford N. Assays for the detection of chemically-induced chromosome damage in cultured mammalian cells. Mutagenicity testing - a practical approach 1984, 187-232. IRL Press Limited, Oxford, England. S. Venitt, J.M. Parry (Eds.).
3. Firenzuoli F., Gori L. Herbal medicine today: clinical and research issues. Evid. Based Complement. Altern. Med. 2007, 4:37-40.
4. Ha H., Lee J. K., Lee H.Y., Koh W.S., Seo C.S., Lee M.Y., Huang D. S. and Shin H. K., 2011. Safety Evaluation of Yukmijihwang-tang: Assessment of Acute and Subchronic Toxicity in Rats. Evid. Based Complement. Altern. Med (doi:). doi:10.1155/2011/672136.
5. Heddle J.A., Stuart E., Salamone M.F. The bone marrow micronucleus test. Handbook of Mutagenicity Test Procedures 1984, 441-457. Elsevier Science Publishers BV. second ed. B.J. Kilbey, M. Legator, W. Nichols, C. Ramel (Eds.).
6. International Conference on Harmonisation (ICH) of technical requirements for registration of pharmaceuticals for human use. 2008. Guidance on genotoxicity testing and data interpretation for pharmaceuticals intended for human use S2 (R1). Current step 2 version, 6 March 2008.
7. Ishidate M., Sofuni T., Yoshikawa K. Chromosomal aberration tests in vitro as a primary screening tool for environmental mutagens and/or carcinogens. GANN Monograph on Cancer Res. 1981, 27:95-107.
8. JEMS-MMS, 1988. Atlas of chromosome aberration by chemicals, Japanese Environmental Mutagen Society-Mammalian Mutagenicity Study Group, Tokyo, Japan.
9. Kang D.G., Sohn E.J., Moon M.K., Mun Y.J., Woo W.H., Kim M.K., Lee H.S. Yukmijihwang-tang ameliorates ischemia/reperfusion-induced renal injury in rats. J. Ethnopharm. 2006, 104:47-53.
10. Lee J.T. Research on intake of Chinese Medicine by Korean 2006, KFDA, Seoul, Korea, pp. 91.
11. Lee J.K., Lee N.H., Ha H., Lee H.Y., Jung D.Y., Choi J.Y., Seo C.S., Shin H.K. Analysis of studies on Yukmijihwang-tang for establishment of evidence based medicine. Kor. J. Orient. Physiol. Pathol. 2009, 23(1):15-26.
12. Lovell D.P., Anderson D., Albanese R., Amphlett G.E., Clare G., Ferguson R., Richold M., Papworth D.G., Savage J.R.K. Statistical analysis on in vitro cytogenetic assays. Statistical evaluation of Mutagenicity Test Data 1989, 184-232. Cambridge University Press, Cambridge, U.K. D.J. Kirkland (Ed.).
13. Maron D.M., Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 1983, 113:173-215.
14. Organization for Economic Cooperation and Development (OECD) Guidelines for the Testing of Chemicals, 1997a. 'Bacterial reverse mutation test' (OECD TG#471).
15. OECD Guidelines for the Testing of Chemicals, 1997b. 'In vitro mammalian chromosome aberration test' (OECD TG#473).
16. OECD Guidelines for the Testing of Chemicals, 1997c. 'Mammalian erythrocyte micronucleus test' (OECD TG#474).
17. Park S.D. Prescriptionology 2003, Young Lim Press, Seoul, Korea, pp. 298-300.
18. QF Information Consulting Co., 2010. The Report of Competition Pattern and Investment Strategy on "Liu wei di huang pills" (2009-2012). pp.34.
19. Rho S.W., Kang M.K., Choi B.O., Sim D.S., Lee J.W., Lee E.A. Effects of Yukmijihwang-tang derivatives (YMJD), a memory enhancing herbal extract, on the gene-expression profile in the rat hippocampus. Biol. Pharm. Bull. 2005, 28(1):87-93.
20. Richardson C., Williams D.A., Allen J.A., Amphlett G., Chanter D.O., Phillips B. Analysis of data from in vitro cytogenetics assays. Statistical Evaluation of Mutagenicity Test Data 1989, 141-154. Cambridge University Press, Cambridge, U.K. D.J. Kirkland (Ed.).
21. Schmid W. The micronucleus test. Mutat. Res. 1975, 31:9-15.
22. Wang J., Heijden R., Spruit S., Hankermeier T., Chan K., Greef J., Xu G., Wang M. Quality and safety of Chinese herbal medicines guided by a systems biology perspective. J. Ethnopharm. 2009, 126:31-41.
23. Wei X.L. Studies on learning and memory function-related genes in the hipocampus and the relationship between the cognitive enhancing effect of liuwei dihuang decoction (LW) and gene expression. Sheng Li Ke Xue Jin Zhan 2000, 31(3):227-230.
24. Wu Y.C., Hsu H., Liu I.M., Liou S.S., Su H.C., Cheng J.T. Increase of insulin sensitivity in diabetic rats received Die-Huang-Wan, a herbal mixture used in Chinese traditional medicine. Acta. Pharmacol. Sin. 2002, 23(12):1181-1187.