In a trial of the use of miltefosine to treat HIV-related cryptosporidiosis in Zambian adults, extreme metabolic disturbances contribute to high mortality

Annals of Tropical Medicine and Parasitology

Volumn 105, Issue 2, 2011, Pages 129-134

  Sinkala, E ^a   Katubulushi, M ^a   Sianongo, S ^a   Obwaller, A ^b   Kelly, P ^a,c  

^a UNIVERSITY OF ZAMBIA   (Zambia)

^b Orphanidis GmbH   (Austria)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MAGNESIUM; MILTEFOSINE; PHOSPHATE; POTASSIUM;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL TRIAL; COLON DISEASE; COLONIC INFARCTION; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM HOMINIS; CRYPTOSPORIDIUM PARVUM; DEHYDRATION; DIARRHEA; DRUG EFFICACY; DRUG FATALITY; DRUG SAFETY; FEMALE; FLUID THERAPY; HIV RELATED CRYPTOSPORIDIOSIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPOKALEMIA; HYPOMAGNESEMIA; HYPOPHOSPHATEMIA; IMMUNOCOMPROMISED PATIENT; INTESTINE OBSTRUCTION; KIDNEY DYSFUNCTION; KIDNEY FAILURE; MAGNESIUM BLOOD LEVEL; MALE; METABOLIC DISORDER; MORTALITY; OLIGURIA; OOCYST; PHOSPHATE BLOOD LEVEL; SIDE EFFECT; ZAMBIA;

ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; CRYPTOSPORIDIOSIS; DIARRHEA; EARLY TERMINATION OF CLINICAL TRIALS; FEMALE; FLUID THERAPY; HUMANS; LIVER; MALE; PHOSPHORYLCHOLINE; RENAL INSUFFICIENCY; TREATMENT OUTCOME; YOUNG ADULT;

EID: 79952677973     PISSN: 00034983     EISSN: 13648594     Source Type: Journal    
DOI: 10.1179/136485911X12899838683160     Document Type: Article

References (25)

1. Abubakar, I., Aliyu, S. H., Arumugam, C., Hunter, P. R. & Usman, N. K. (2007). Prevention and Treatment of Cryptosporidiosis in Immunocompromised Patients. Cochrane Database of Systematic Reviews 2007. Art. No. CD004932. Chichester, U.K.: John Wiley & Sons.
2. Amadi, B. C., Kelly, P., Mwiya, M., Mulwazi, E., Sianongo, S., Changwe, F., Thomson, M., Hachungula, J., Watuka, A., Walker-Smith, J. A. & Chintu, C. (2001). Intestinal and systemic infection, HIV and mortality in Zambian children with persistent diarrhoea and malnutrition. Journal of Pediatric Gastroenterology and Nutrition, 32, 550-554. (Pubitemid 32601806)
3. Amadi, B. C., Mwiya, M., Musuku, J., Watuka, A., Sianongo, S., Ayoub, A. & Kelly, P. (2002). Effect of nitazoxanide on morbidity and mortality in Zambian children with cryptosporidiosis: a randomised controlled trial. Lancet, 360, 1375-1380. (Pubitemid 35341302)
4. Azzouz, S., Maache, M., Garcia, R. G. & Osuna, A. (2005). Leishmanicidal activity of edelfosine, miltefosine, and ilmofosine. Basic and Clinical Pharmacology and Toxicology, 96, 60-65. (Pubitemid 40260848)
5. Cacciò, S. M. & Pozio, E. (2006). Advances in the epidemiology, diagnosis and treatment of cryptosporidiosis. Expert Review of Anti-infective Therapy, 4, 429-443. (Pubitemid 43905465)
6. Dionisio, D., Orsi, A., Sterantino, G., Meli, M., di Lollo, S., Ibba Manneschi, L., Trotta, M., Pozzi, M.,, Sani, L. & Leoncini, F. (1998). Chronic cryptosporidiosis in patients with AIDS: stable remission and possible eradication after long-term, low dose azithromycin. Journal of Clinical Pathology, 51, 138-142. (Pubitemid 28140728)
7. Eibl, H. & Unger, C. (1990). Hexadecylphosphocholine: a new and selective antitumor drug. Cancer Treatment Reviews, 17, 233-242.
8. Fichtenbaum, C. J., Zackin, R., Feinberg, J., Benson, C. & Griffiths, J. K. (2000). Rifabutin but not clarithromycin prevents cryptosporidiosis in persons with advanced HIV infection. AIDS, 14, 2889-2893. (Pubitemid 32042752)
9. Gentile, G., Venditti, M., Micozzi, A., Caprioli, A., Donelli, G., Tirindelli, C., Meloni, G., Arcese, W. & Martino P. (1991). Cryptosporidiosis in patients with hematologic malignancies. Reviews of Infectious Diseases, 13, 842-846.
10. Hewitt, R. G., Yiannoutsos, C. T., Higgs, E. S., Carey, J. T., Geiseler, P. J., Saove, R., Rosenberg, R., Vazquez, G. J., Wheat, L. J., Fass, R. J., Antoninievic, Z., Walawander, A. L., Flanigan, T. P. & Bender, J. F. (2000). Paromomycin: no more effective than placebo for treatment of cryptosporidiosis in patients with advanced human immunodeficiency virus infection. Clinical Infectious Diseases, 31, 1084-1092. (Pubitemid 32299370)
11. Holmberg, S. D., Moorman, A. C., von Bargen, J. C., Palella, F. J., Loveless, M. O., Ward, D. J. & Navin, T. R. (1998). Possible effectiveness of clarithromycin and rifabutin for cryptosporidiosis chemoprophylaxis in HIV disease. HIV Outpatient Study (HOPS) Investigators. Journal of the American Medical Association, 279, 384-386. (Pubitemid 28133869)
12. Kadappu, K. K., Nagaraja, M. V., Rao, P. V. & Shastry, B. A. (2002). Azithromycin as treatment for cryptosporidiosis in human immunodeficiency virus disease. Journal of Postgraduate Medicine, 48, 179-181. (Pubitemid 35386072)
13. Kaile, T., Zulu, I., Lumayi, R., Ashman, N. & Kelly, P. (2008). Inappropriately low aldosterone concentrations in adults with AIDS-related diarrhoea in Zambia: a study of response to fluid challenge. BMC Research Notes, 1, 10.
14. Mor, S. M. & Tzipori, S. (2008). Cryptosporidiosis in children in sub-Saharan Africa: a lingering challenge. Clinical Infectious Diseases, 47, 915-921.
15. Mwinga, A., Hosp, M., Zulu, I., Farthing, M. J. G., Mulambo, S. & Kelly, P. (2002). Tuberculosis preventative treatment also prevented diarrhoea in HIV-infected patients in Zambia. AIDS, 16, 806-808. (Pubitemid 34274481)
16. Pronk, L. C., Planting, A. S., Oosterom, R., Drogendijk, T. E., Stoter, G. & Verweij, J. (1994). Increases in leucocyte and platelet counts induced by the alkyl phospholipid hexadecylphosphocholine. European Journal of Cancer, 30A, 1019-1022. (Pubitemid 24256255)
17. Rossignol, J.-F. (2006). Nitazoxanide in the treatment of acquired immune deficiency syndrome-related cryptosporidiosis: results of the United States compassionate use program in 365 patients. Alimentary Pharmacology and Therapetics, 24, 887-894.
18. Rossignol, J.-F., Ayoub, A. & Ayers, M. S. (2001). Treatment of diarrhoea caused by Cryptosporidium parvum: a prospective randomized, double-blind, placebo-controlled study of nitazoxanide. Journal of Infectious Diseases, 184, 103-106. (Pubitemid 32568508)
19. Sundar, S. & Olliaro, P. L. (2007). Miltefosine in the treatment of leishmaniasis: clinical evidence for informed risk management. Therapeutics and Clinical Risk Management, 3, 733-740. (Pubitemid 350162073)
20. Sundar, S., Jha, T. K., Thakur, C. P., Bhattacharya, S. K. & Rai, M. (2003). Oralmiltefosine treatment in children with mild to moderate Indian visceral leishmaniasis. Pediatric Infectious Disease Journal, 22, 434-438. (Pubitemid 36578746)
21. Theischen, M., Bornfeld, N., Becher, R., Kellner, U. & Wessing, A. (1993). Hexadecylphosphocholine may produce reversible functional defects of the retinal pigment epithelium. German Journal of Ophthalmology, 2, 113-115.
22. Unger, C., Damenz, W., Fleer, E. A., Kim, D. J., Breiser, A., Hilgard, P., Engel, J., Nagel, G. & Eibl, H. (1989). Hexadecylphosphocholine, a new ether lipid analogue. Studies on the antineoplastic activity in vitro and in vivo. Acta Oncologica, 28, 213-217.
23. Verweij, J., Planting, A., van der Burg, M. & Stoter, G. (1992). A dose-finding study of miltefosine (hexadecylphosphocholine) in patients with metastatic solid tumours. Journal of Cancer Research and Clinical Oncology, 118, 606-608.
24. White, A. C., Cron, S. G. & Chappell, C. L. (2001). Paromomycin in cryptosporidiosis. Clinical Infectious Diseases, 32, 1516-1517.
25. White, A. C., Robinson, P. & Okhuysen, P. C. (2003). Human studies provide insight into the pathogenesis, immunology, and treatment of cryptosporidiosis. Clinical Infectious Diseases, 37, 989.