Does adipose tissue have a key role in inflammation in CKD?

Journal of Internal Medicine

Volumn 269, Issue 4, 2011, Pages 407-409

  Zoccali, C ^a   Mallamaci, F ^a  

^a CNR Consiglio Nazionale delle Ricerche   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA POLYPEPTIDE; CYTOCHROME B; CYTOCHROME B245; LEPTIN; POLYPEPTIDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2;

ADIPOSE TISSUE; BODY MASS; CHRONIC KIDNEY DISEASE; EDITORIAL; GENE EXPRESSION; HUMAN; KIDNEY FAILURE; NEPHRITIS; OXIDATIVE STRESS; PRIORITY JOURNAL; UREMIA;

ADIPOSE TISSUE; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; KIDNEY FAILURE, CHRONIC;

EID: 79952655215     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2010.02342.x     Document Type: Editorial

References (14)

1. Zoccali C. The obesity epidemics in ESRD: from wasting to waist? Nephrol Dial Transplant 2009; 24: 376-80.
2. Kramer HJ, Saranathan A, Luke A et al. Increasing body mass index and obesity in the incident ESRD population. J Am Soc Nephrol 2006; 17: 1453-9.
3. Honda H, Qureshi AR, Axelsson J et al. Obese sarcopenia in patients with end-stage renal disease is associated with inflammation and increased mortality. Am J Clin Nutr 2007; 86: 633-8.
4. Postorino M, Marino C, Tripepi G, Zoccali C. Abdominal obesity and all-cause and cardiovascular mortality in end-stage renal disease. J Am Coll Cardiol 2009; 53: 1265-72.
5. Cordeiro AC, Qureshi AR, Stenvinkel P et al. Abdominal fat deposition is associated with increased inflammation, protein-energy wasting and worse outcome in patients undergoing haemodialysis. Nephrol Dial Transplant 2010; 25: 562-8.
6. Witasp A, Carrero JJ, Heimburger O et al. Increased expression of pro-inflammatory genes in abdominal subcutaneous fat in advanced chronic kidney disease patients. J Intern Med 2011 (in press).
7. Wang X, Axelsson J, Nordfors L et al. Changes in fat mass after initiation of maintenance dialysis is influenced by the uncoupling protein 2 exon 8 insertion/deletion polymorphism. Nephrol Dial Transplant 2007; 22: 196-202.
8. Zhou H, Zhao J, Zhang X. Inhibition of uncoupling protein 2 by genipin reduces insulin-stimulated glucose uptake in 3T3-L1 adipocytes. Arch Biochem Biophys 2009; 486: 88-93.
9. Dinauer MC, Pierce EA, Bruns GA, Curnutte JT, Orkin SH. Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. J Clin Invest 1990; 86: 1729-37.
10. Charriere G, Cousin B, Arnaud E et al. Preadipocyte conversion to macrophage. Evidence of plasticity 2. J Biol Chem 2003; 278: 9850-5.
11. Lim WH, Kireta S, Leedham E, Russ GR, Coates PT. Uremia impairs monocyte and monocyte-derived dendritic cell function in hemodialysis patients. Kidney Int 2007; 72: 1138-48.
12. Girndt M, Ulrich C, Kaul H, Sester U, Sester M, Kohler H. Uremia-associated immune defect: the IL-10-CRP axis. Kidney Int Suppl 2003; 84: S76-9.
13. Fasshauer M, Klein J, Lossner U, Paschke R. Interleukin (IL)-6 mRNA expression is stimulated by insulin, isoproterenol, tumour necrosis factor alpha, growth hormone, and IL-6 in 3T3-L1 adipocytes. Horm Metab Res 2003; 35: 147-52.
14. Roubicek T, Bartlova M, Krajickova J et al. Increased production of proinflammatory cytokines in adipose tissue of patients with end-stage renal disease. Nutrition 2009; 25: 762-8.