CD154 Expression Is Associated with Neutralizing Antibody Titer Levels Postinfluenza Vaccination in Stem Cell Transplant Patients and Healthy Adults

Biology of Blood and Marrow Transplantation

Volumn 17, Issue 4, 2011, Pages 524-533

  Seidel, Aprille ^a   Smith, David ^a   Yung, Edward ^a   Aquino, Lia ^a   Srivastava, Tumul ^a   Pullarkat, Vinod ^a   Spielberger, Ricardo ^a   Forman, Stephen J ^a   Diamond, Don J ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

CD154; CD40L; Influenza; Stem cell transplant; Vaccination

Indexed keywords

CD4 ANTIGEN; CD40 LIGAND; GAMMA INTERFERON; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; NEUTRALIZING ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANTIBODY TITER; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; BLOOD SAMPLING; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HEMAGGLUTINATION INHIBITION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; INFLUENZA VACCINATION; INFLUENZA VIRUS; LONGITUDINAL STUDY; MALE; PROSPECTIVE STUDY; T LYMPHOCYTE ACTIVATION; VIRUS INACTIVATION;

ADULT; AGED; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INFLUENZA, HUMAN; INTERFERON-GAMMA; MALE; MIDDLE AGED; STEM CELL TRANSPLANTATION; TRANSPLANTATION, HOMOLOGOUS; TUMOR NECROSIS FACTOR-ALPHA; VACCINATION;

EID: 79952624204     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2010.04.015     Document Type: Article

References (48)

1. Parkman R., Weinberg K.I. Immunological reconstitution following bone marrow transplantation. Immunol Rev 1997, 157:73-78.
2. Ljungman P., Lewensohn-Fuchs I., Hammarstrom V., et al. Long-term immunity to measles, mumps, and rubella after allogeneic bone marrow transplantation. Blood 1994, 84:657-663.
3. Blume K.G., Forman, Stephen J., Appelbaum, Frederick R. Thomas' Hematopoietic Cell Transplantation 2004, Blackwell Pub., Malden, MA.
4. Holmberg L.A., Boeckh M., Hooper H., et al. Increased incidence of cytomegalovirus disease after autologous CD34-selected peripheral blood stem cell transplantation. Blood 1999, 94:4029-4035.
5. Crippa F., Holmberg L., Carter R.A., et al. Infectious complications after autologous CD34-selected peripheral blood stem cell transplantation. Biol Blood Marrow Transplant 2002, 8:281-289.
6. Gandhi M.K., Egner W., Sizer L., et al. Antibody responses to vaccinations given within the first two years after transplant are similar between autologous peripheral blood stem cell and bone marrow transplant recipients. Bone Marrow Transplant 2001, 28:775-781.
7. Dykewicz C.A., Jaffe H.W., Kaplan J.E. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. MMWR Recomm Rep 2000, 49:1-125. CE121-127.
8. Avetisyan G., Aschan J., Hassan M., Ljungman P. Evaluation of immune responses to seasonal influenza vaccination in healthy volunteers and in patients after stem cell transplantation. Transplantation 2008, 86:257-263.
9. Engelhard D., Nagler A., Hardan I., et al. Antibody response to a two-dose regimen of influenza vaccine in allogeneic T cell-depleted and autologous BMT recipients. Bone Marrow Transplant 1993, 11:1-5.
10. Haining W.N., Evans J.W., Seth N.P., et al. Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation. Br J Haematol 2004, 127:322-325.
11. Hara M., Sakamoto T., Tanaka K. Effectiveness of influenza vaccination in preventing influenza-like illness among community-dwelling elderly: population-based cohort study in Japan. Vaccine 2006, 24:5546-5551.
12. Machado C.M., Cardoso M.R., da Rocha I.F., Boas L.S., Dulley F.L., Pannuti C.S. The benefit of influenza vaccination after bone marrow transplantation. Bone Marrow Transplant 2005, 36:897-900.
13. Mori S., Kocak U., Shaw J.L., Mullen C.A. Augmentation of post transplant immunity: antigen encounter at the time of hematopoietic stem cell transplantation enhances antigen-specific donor T-cell responses in the post transplant repertoire. Bone Marrow Transplant 2005, 35:793-801.
14. Karl G., Blume S.J.F., Frederick R., Appelbaum Thomas' Hematopoietic Cell Transplantation 2004, Blackwell Pub., Malden, MA.
15. Storek J., Ferrara S., Ku N., Giorgi J.V., Champlin R.E., Saxon A. B cell reconstitution after human bone marrow transplantation: recapitulation of ontogeny?. Bone Marrow Transplant 1993, 12:387-398.
16. Parra C., Roldan E., Brieva J.A. Deficient expression of adhesion molecules by human CD5- B lymphocytes both after bone marrow transplantation and during normal ontogeny. Blood 1996, 88:1733-1740.
17. Lee B.O., Rangel-Moreno J., Moyron-Quiroz J.E., et al. CD4 T cell-independent antibody response promotes resolution of primary influenza infection and helps to prevent reinfection. J Immunol 2005, 175:5827-5838.
18. Kannanganat S., Ibegbu C., Chennareddi L., Robinson H.L., Amara R.R. Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells. J Virol 2007, 81:8468-8476.
19. Eaton S.M., Burns E.M., Kusser K., Randall T.D., Haynes L. Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses. J Exp Med 2004, 200:1613-1622.
20. Tang Y.C., Thoman M., Linton P.J., Deisseroth A. Use of CD40L immunoconjugates to overcome the defective immune response to vaccines for infections and cancer in the aged. Cancer Immunol Immunother 2009, 58:1949-1957.
21. Soesman N.M., Rimmelzwaan G.F., Nieuwkoop N.J., et al. Efficacy of influenza vaccination in adult liver transplant recipients. J Med Virol 2000, 61:85-93.
22. Duchini A., Hendry R.M., Nyberg L.M., Viernes M.E., Pockros P.J. Immune response to influenza vaccine in adult liver transplant recipients. Liver Transpl 2001, 7:311-313.
23. Mazzone P.J., Mossad S.B., Mawhorter S.D., Mehta A.C., Schilz R.J., Maurer J.R. The humoral immune response to influenza vaccination in lung transplant patients. Eur Respir J 2001, 18:971-976.
24. Ljungman P., Avetisyan G. Influenza vaccination in hematopoietic SCT recipients. Bone Marrow Transplant 2008, 42:637-641.
25. Gelinck L.B., van den Bemt B.J., Marijt W.A., et al. Intradermal influenza vaccination in immunocompromized patients is immunogenic and feasible. Vaccine 2009, 27:2469-2474.
26. Centers for Disease Control and Prevention. Recommendations for Influenza vaccination and flu statistics. Available at. ; 2009. http://www.cdc.gov/flu/.
27. Buser A., Stern M., Arber C., et al. Impaired B-cell reconstitution in lymphoma patients undergoing allogeneic HSCT: an effect of pretreatment with rituximab?. Bone Marrow Transplant 2008, 42:483-487.
28. Machado C.M. Influenza infections after hematopoietic stem cell transplantation. Clin Infect Dis 2005, 41:273-274.
29. Chattopadhyay P.K., Yu J., Roederer M. A live-cell assay to detect antigen-specific CD4+ T cells with diverse cytokine profiles. Nat Med 2005, 11:1113-1117.
30. Ford M.L., Koehn B.H., Wagener M.E., et al. Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation. J Exp Med 2007, 204:299-309.
31. Lacey S.F., Diamond D.J., Zaia J.A. Assessment of cellular immunity to human cytomegalovirus in recipients of allogeneic stem cell transplants. Biol Blood Marrow Transplant 2004, 10:433-447.
32. Swain S.L., Agrewala J.N., Brown D.M., et al. CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza. Immunol Rev 2006, 211:8-22.
33. Avetisyan G., Ragnavolgyi E., Toth G.T., Hassan M., Ljungman P. Cell-mediated immune responses to influenza vaccination in healthy volunteers and allogeneic stem cell transplant recipients. Bone Marrow Transplant 2005, 36:411-415.
34. Kang I., Hong M.S., Nolasco H., et al. Age-associated change in the frequency of memory CD4+ T cells impairs long term CD4+ T cell responses to influenza vaccine. J Immunol 2004, 173:673-681.
35. He X.S., Holmes T.H., Sasaki S., et al. Baseline levels of influenza-specific CD4 memory T-cells affect T-cell responses to influenza vaccines. PLoS ONE 2008, 3:e2574.
36. Brown D.M., Dilzer A.M., Meents D.L., Swain S.L. CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch. J Immunol 2006, 177:2888-2898.
37. Palladino G., Scherle P.A., Gerhard W. Activity of CD4+ T-cell clones of type 1 and type 2 in generation of influenza virus-specific cytotoxic responses in vitro. J Virol 1991, 65:6071-6076.
38. Ruat C., Caillet C., Bidaut A., Simon J., Osterhaus A.D. Vaccination of macaques with adjuvanted formalin-inactivated influenza A virus (H5N1) vaccines: protection against H5N1 challenge without disease enhancement. J Virol 2008, 82:2565-2569.
39. Jackson LA, Gaglani MJ, Keyserling HL, et al. Safety, efficacy, and immunogenicity of an inactivated influenza vaccine in healthy adults: a randomized, placebo-controlled trial over two influenza seasons. BMC Infect Dis. 10:71.
40. La Montagne J.R., Noble G.R., Quinnan G.V., et al. Summary of clinical trials of inactivated influenza vaccine-1978. Rev Infect Dis 1983, 5:723-736.
41. Jefferson T., Smith S., Demicheli V., Harnden A., Rivetti A., Di Pietrantonj C. Assessment of the efficacy and effectiveness of influenza vaccines in healthy children: systematic review. Lancet 2005, 365:773-780.
42. Beyer W.E., Palache A.M., Osterhaus A.D. Comparison of serology and reactogenicity between influenza subunit vaccines and whole virus or split vaccines: a review and meta-analysis of the literature. Clin Drug Invest 1998, 15:1-12.
43. Co M.D., Orphin L., Cruz J., et al. In vitro evidence that commercial influenza vaccines are not similar in their ability to activate human T cell responses. Vaccine 2009, 27:319-327.
44. Levin M.J., Song L.Y., Fenton T., et al. Shedding of live vaccine virus, comparative safety, and influenza-specific antibody responses after administration of live attenuated and inactivated trivalent influenza vaccines to HIV-infected children. Vaccine 2008, 26:4210-4217.
45. Monto A.S., Ohmit S.E., Petrie J.G., et al. Comparative efficacy of inactivated and live attenuated influenza vaccines. N Engl J Med 2009, 361:1260-1267.
46. Centers for Disease Control and Prevention. Recommendations for Influenza vaccination and flu statistics. Available at, 12 November 2009. http://www.cdc.gov/flu.
47. Sasaki S., He X.S., Holmes T.H., et al. Influence of prior influenza vaccination on antibody and B-cell responses. PLoS ONE 2008, 3:e2975.
48. Lausen B.F., Hougs L., Schejbel L., Heilmann C., Barington T. Human memory B cells transferred by allogenic bone marrow transplantation contribute significantly to the antibody repertoire of the recipient. J Immunol 2004, 172:3305-3318.