Progressive multifocal leukoencephalopathy in liver transplant recipients: A case report and review of the literature

Transplant International

Volumn 24, Issue 4, 2011, Pages

  Verhelst, Xavier ^a   Vanhooren, Geert ^a   Vanopdenbosch, Ludo ^a   Casselman, Jan ^a   Laleman, Wim ^b   Pirenne, Jacques ^b   Nevens, Frederik ^b   Orlent, Hans ^a  

^a AZ Sint Jan AV Brugge ^*  (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Immunosuppression; Liver transplantation; Progressive multifocal leukoencephalopathy

Indexed keywords

BASILIXIMAB; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS;

AGED; ARTICLE; CASE REPORT; CEREBROSPINAL FLUID EXAMINATION; CEREBROVASCULAR ACCIDENT; CLINICAL FEATURE; DIFFERENTIAL DIAGNOSIS; DISEASE EXACERBATION; DOSE RESPONSE; DRUG DOSE REDUCTION; FEMALE; GAIT DISORDER; GRAFT RECIPIENT; HUMAN; JC VIRUS; LIVER CIRRHOSIS; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; NUCLEAR MAGNETIC RESONANCE IMAGING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; VERTIGO; VIRUS DETECTION; WHITE MATTER;

AGED; FATAL OUTCOME; FEMALE; HUMANS; IMMUNOCOMPROMISED HOST; IMMUNOSUPPRESSIVE AGENTS; JC VIRUS; LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL; LIVER TRANSPLANTATION;

EID: 79952592879     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2010.01190.x     Document Type: Article

References (20)

1. Tan CS, Koralnik IJ. Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis. Lancet Neurol 2010; 9: 425.
2. Chesters PM, Heritage J, McCance DJ. Persistence of DNA sequences of BK virus and JC virus in normal human tissues and in diseased tissues. J Infect Dis 1983; 147: 676.
3. Sabath BF, Major EO. Traffic of JC virus from sites of initial infection to the brain: the path to progressive multifocal leukoencephalopathy. J Infect Dis 2002; 186(Suppl. 2): S180.
4. Chapagain ML, Verma S, Mercier F, Yanagihara R, Nerurkar VR. Polyomavirus JC infects human brain microvascular endothelial cells independent of serotonin receptor 2A. Virology 2007; 364: 55.
5. Neff RT, Hurst FP, Falta EM, et al. Progressive multifocal leukoencephalopathy and use of mycophenolate mofetil after kidney transplantation. Transplantation 2008; 86: 1474.
6. Worthmann F, Turker T, Muller AR, Patt S, Stoltenburg-Didinger G. Progressive multifocal leukoencephalopathy after orthotopic liver transplantation. Transplantation 1994; 57: 1268.
7. Aksamit Jr AJ, de Groen PC. Cyclosporine-related leukoencephalopathy and PML in a liver transplant recipient. Transplantation 1995; 60: 874.
8. Bronster DJ, Lidov MW, Wolfe D, Schwartz ME, Miller CM. Progressive multifocal leukoencephalopathy after orthotopic liver transplantation. Liver Transpl Surg 1995; 1: 371.
9. Boulton-Jones JR, Fraser-Moodie C, Ryder SD. Long term survival from progressive multifocal leucoencephalopathy after liver transplantation. J Hepatol 2001; 35: 828.
10. Lima MA, Hanto DW, Curry MP, Wong MT, Dang X, Koralnik IJ. Atypical radiological presentation of progressive multifocal leukoencephalopathy following liver transplantation. J Neurovirol 2005; 11: 46.
11. Alibert S, Gerolami R, Tammam D, et al. Progressive multifocal leukoencephalopathy secondary to JC virus infection after liver transplantation and treatment of recurrent hepatitis C. Gastroenterol Clin Biol 2006; 30: 473.
12. Yehia B, Davison A, Sisson S. Transplant troubles. Am J Med 2009; 122: 629.
13. Martinez AJ, Ahdab-Barmada M. The neuropathology of liver transplantation: comparison of main complications in children and adults. Mod Pathol 1993; 6: 25.
14. Bronster DJ, Emre S, Boccagni P, Sheiner PA, Schwartz ME, Miller CM. Central nervous system complications in liver transplant recipients - incidence, timing, and longterm follow-up. Clin Transplant 2000; 14: 1.
15. Waggoner J, Martinu T, Palmer SM. Progressive multifocal leukoencephalopathy following heightened immunosuppression after lung transplant. J Heart Lung Transplant 2009; 28: 395.
16. McCalmont V, Bennett K. Progressive multifocal leukoencephalopathy: a case study. Prog Transplant 2007; 17: 157.
17. van de Beek D, Patel R, Daly RC, McGregor CG, Wijdicks EF. Central nervous system infections in heart transplant recipients. Arch Neurol 2007; 64: 1715.
18. Campagna F, Biancardi A, Cillo U, Gatta A, Amodio P. Neurocognitive- neurological complications of liver transplantation: a review. Metab Brain Dis 2010; 25: 115.
19. Rudick RA PC, O'Connor PW, Polman CH, et al. Assessment of JC Virus DNA in Blood and urine of Natalizumab-treated patients. Ann Neurol 2010; 68: 304.
20. Brinkert F, Briem-Richter A, Ilchmann C, Kemper MJ, Ganschow R. Prevalence of polyomavirus viruria (JC virus/ BK virus) in children following liver transplantation. Pediatr Transplant 2010; 14: 105.