Synthesis of 4-unsubstituted dihydropyrimidines. Nucleophilic substitution at position-2 of dihydropyrimidines

Tetrahedron

Volumn 67, Issue 14, 2011, Pages 2661-2669

  Cho, Hidetsura ^a   Nishimura, Yoshio ^a,b   Yasui, Yoshizumi ^a   Kobayashi, Satoshi ^a   Yoshida, Shin Ichiro ^a   Kwona, Eunsang ^a   Yamaguchi, Masahiko ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b YASUDA WOMEN'S UNIVERSITY   (Japan)

Author keywords

2,3,5,8 Tetrahydro 1,2,4 triazolo 4,3 a ; Dihydropyrimidine; Individual tautomer; Nucleophilic substitution; Pyrimidine; Tautomerism; X ray diffraction

Indexed keywords

1 TERT BUTYL 5 ETHYL 2 (3 DIMETHYLAMINOMETHYL CHROMAN 6 YLAMINO) 4 METHYL 1,6 DIHYDROPYRIMIDINE 1,5 DICARBOXYLATE; 1 TERT BUTYL 5 ETHYL 2 (4 METHOXYCARBONYLPHENYLAMINO) 4 METHYL 1,6 DIHYDROPYRIMIDINE 1,5 DICARBOXYLATE; 1 TERT BUTYL 5 ETHYL 2 (4 METHOXYPHENYLAMINO) 4 METHYL 1,6 DIHYDROPYRIMIDINE 1,5 DICARBOXYLATE; 1 TERT BUTYL 5 ETHYL 2 BENZYLAMINO 4 METHYL 1,6 DIHYDROPYRIMIDINE 1,5 DICARBOXYLATE; 1 TERT BUTYL 5 ETHYL 2 BENZYLOXYAMINO 4 METHYL 1,6 DIHYDROPYRIMIDINE 1,5 DICARBOXYLATE; 1 TERT BUTYL 5 ETHYL 2 HEXYLAMINO 4 METHYL 1,6 DIHYDROPYRIMIDINE 1,5 DICARBOXYLATE; 1 TERT BUTYL 5 ETHYL 2 PYRROLIDYL 4 METHYL 1,6 DIHYDROPYRIMIDINE 1,5 DICARBOXYLATE; 1 TERT BUTYL 5 ETHYL 4 METHYL 2 METHYLSULFANYL 1,6 DIHYDROPYRIMIDINE 1,5 DICARBOXYLATE; 1 TERT BUTYL 5 ETHYL 4 METHYL 2 PHENYLAMINO 1,6 DIHYDROPYRIMIDINE 1,5 DICARBOXYLATE; 3 OXO 2 PHENYL 2,3,5,8 TETRAHYDRO[1,2,4]TRIAZOLO[4,3 A]PYRIMIDINE; AMINE; DIHYDROPYRIMIDINE; PHENYLHYDRAZINE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKOXYCARBONYLATION; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; NUCLEOPHILIC SUBSTITUTION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TAUTOMER; X RAY CRYSTALLOGRAPHY;

EID: 79952575157     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2011.01.092     Document Type: Article

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