The effects of midazolam and sevoflurane on the GABAA receptors with alternatively spliced variants of the γ2 subunit

Korean Journal of Anesthesiology

Volumn 60, Issue 2, 2011, Pages 109-118

  Eom, Woosik ^a   Lee, Jung Min ^b   Park, Jeongmi ^b   Choi, Kyungho ^a   Jung, Sung Jun ^c   Kim, Hee Soo ^b  

^a National Cancer Center   (South Korea)

^b Seoul National University Hospital   (South Korea)

^c Hanyang University College of Medicine   (South Korea)

Author keywords

Agitation; Alternative splicing; GABAA receptor; Gamma 2 subunit; Midazolam; Sevoflurane

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2; MIDAZOLAM; SEVOFLURANE;

ALTERNATIVE RNA SPLICING; ARTICLE; CELL STRAIN HEK293; CONCENTRATION RESPONSE; DRUG EFFECT; HUMAN; HUMAN CELL; PATCH CLAMP; PROTEIN EXPRESSION;

EID: 79952549437     PISSN: 20056419     EISSN: 20057563     Source Type: Journal    
DOI: 10.4097/kjae.2011.60.2.109     Document Type: Article

References (30)

1. Zimmerman SA, Jones MV, Harrison NL. Potentiation of gamma-aminobutyric acidA receptor Cl- current correlates with in vivo anesthetic potency. J Pharmacol Exp Ther 1994; 270: 987-91.
2. Macdonald RL, Olsen RW. GABAA receptor channels. Annu Rev Neurosci 1994; 17: 569-602. (Pubitemid 2067782)
3. Sieghart W, Sperk G. Subunit composition, distribution and function of GABA(A) receptor subtypes. Curr Top Med Chem 2002; 2: 795-816.
4. Machu TK, Firestone JA, Browning MD. Ca2+/calmodulin-dependent protein kinase II and protein kinase C phosphorylate a synthetic peptide corresponding to a sequence that is specific for the gamma 2L subunit of the GABAA receptor. J Neurochem 1993; 61: 375-7. (Pubitemid 23175928)
5. Gutiérrez A, Khan ZU, Ruano D, Miralles CP, Vitorica J, De Blas AL. Aging-related subunit expression changes of the GABAA receptor in the rat hippocampus. Neuroscience 1996; 74: 341-8. (Pubitemid 26274206)
6. Wang JB, Burt DR. Differential expression of two forms of GABAA receptor gamma 2-subunit in mice. Brain Res Bull 1991; 27: 731-5.
7. Wisden W, Laurie DJ, Monyer H, Seeburg PH. The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J Neurosci 1992; 12: 1040-62.
8. Laurie DJ, Seeburg PH, Wisden W. The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J Neurosci 1992; 12: 1063-76.
9. McKernan RM, Whiting PJ. Which GABAA-receptor subtypes really occur in the brain? Trends Neurosci 1996; 19: 139-43.
10. McKernan RM, Wafford K, Quirk K, Hadingham KL, Harley EA, Ragan CI, et al. The pharmacology of the benzodiazepine site of the GABA-A receptor is dependent on the type of gamma-subunit present. J Recept Signal Transduct Res 1995; 15: 173-83.
11. Lerman J, Sikich N, Kleinman S, Yentis S. The pharmacology of sevoflurane in infants and children. Anesthesiology 1994; 80: 814-24. (Pubitemid 24128945)
12. Cravero JP, Beach M, Dodge CP, Whalen K. Emergence characteristics of sevoflurane compared to halothane in pediatric patients undergoing bilateral pressure equalization tube insertion. J Clin Anesth 2000; 12: 397-401.
13. Aono J, Ueda W, Mamiya K, Takimoto E, Manabe M. Greater incidence of delirium during recovery from sevoflurane anesthesia in preschool boys. Anesthesiology 1997; 87: 1298-300. (Pubitemid 28007323)
14. Ko YP, Huang CJ, Hung YC, Su NY, Tsai PS, Chen CC, et al. Premedication with low-dose oral midazolam reduces the incidence and severity of emergence agitation in pediatric patients following sevoflurane anesthesia. Acta Anaesthesiol Sin 2001; 39: 169-77.
15. Lindenmayer JP. The pathophysiology of agitation. J Clin Psychiatry 2000; 61 Suppl 14: 5-10.
16. Pritchett DB, Sontheimer H, Shivers BD, Ymer S, Kettenmann H, Schofield PR, et al. Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology. Nature 1989; 338: 582-5. (Pubitemid 19102309)
17. Sebel LE, Richardson JE, Singh SP, Bell SV, Jenkins A. Additive effects of sevoflurane and propofol on gamma-aminobutyric acid receptor function. Anesthesiology 2006; 104: 1176-83. (Pubitemid 43852950)
18. Chen C, Okayama H. High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 1987; 7: 2745-52.
19. Wells LT, Rasch DK. Emergence "delirium" after sevoflurane anesthesia: a paranoid delusion? Anesth Analg 1999; 88: 1308-10.
20. Welborn LG, Hannallah RS, Norden JM, Ruttimann UE, Callan CM. Comparison of emergence and recovery characteristics of sevoflurane, desflurane, and halothane in pediatric ambulatory patients. Anesth Analg 1996; 83: 917-20. (Pubitemid 26365400)
21. Short TG, Plummer JL, Chui PT. Hypnotic and anaesthetic interactions between midazolam, propofol and alfentanil. Br J Anaesth 1992; 69: 162-7.
22. Khan ZU, Gutiérrez A, Miralles CP, De Blas AL. The gamma subunits of the native GABAA/benzodiazepine receptors. Neurochem Res 1996; 21: 147-59.
23. Rüsch D, Forman SA. Classic benzodiazepines modulate the open-close equilibrium in alpha1beta2gamma2L gamma-aminobutyric acid type A receptors. Anesthesiology 2005; 102: 783-92.
24. Sigel E, Baur R, Trube G, Möhler H, Malherbe P. The effect of subunit composition of rat brain GABAA receptors on channel function. Neuron 1990; 5: 703-11.
25. Kneussel M. Dynamic regulation of GABA(A) receptors at synaptic sites. Brain Res Brain Res Rev 2002; 39: 74-83. (Pubitemid 34666987)
26. Baulac S, Huberfeld G, Gourfinkel-An I, Mitropoulou G, Beranger A, Prud'homme JF, et al. First genetic evidence of GABA(A) receptor dysfunction in epilepsy: a mutation in the gamma2-subunit gene. Nat Genet 2001; 28: 46-8.
27. Huntsman MM, Tran BV, Potkin SG, Bunney WE Jr, Jones EG. Altered ratios of alternatively spliced long and short gamma2 subunit mRNAs of the gamma-amino butyrate type A receptor in prefrontal cortex of schizophrenics. Proc Natl Acad Sci U S A 1998; 95: 15066-71. (Pubitemid 29003757)
28. Quinlan JJ, Firestone LL, Homanics GE. Mice lacking the long splice variant of the gamma 2 subunit of the GABA(A) receptor are more sensitive to benzodiazepines. Pharmacol Biochem Behav 2000; 66: 371-4. (Pubitemid 30394625)
29. Whiting P, McKernan RM, Iversen LL. Another mechanism for creating diversity in gamma-aminobutyrate type A receptors: RNA splicing directs expression of two forms of gamma 2 phosphorylation site. Proc Natl Acad Sci U S A 1990; 87: 9966-70. (Pubitemid 120016565)
30. Krishek BJ, Xie X, Blackstone C, Huganir RL, Moss SJ, Smart TG. Regulation of GABAA receptor function by protein kinase C phosphorylation. Neuron 1994; 12: 1081-95.