Deficits in reward system activation and impulsivity: A predisposing condition to alcoholism?

Biological Psychiatry

Volumn 69, Issue 7, 2011, Pages 612-613

  Duka, Theodora ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLISM; AMYGDALOID NUCLEUS; BEHAVIOR DISORDER; BRAIN DEPTH STIMULATION; BRAIN DYSFUNCTION; COMPULSION; DISEASE PREDISPOSITION; DRINKING BEHAVIOR; DYSPHORIA; EMOTIONALITY; HIGH RISK BEHAVIOR; HUMAN; IMPULSIVENESS; INSULA; MOOD DISORDER; NEUROBIOLOGY; NEUROCHEMISTRY; NEUROSCIENCE; NOTE; NUCLEUS ACCUMBENS; OBSESSIVE COMPULSIVE DISORDER; ORBITAL CORTEX; PATHOLOGICAL GAMBLING; PERSONALITY; PRIORITY JOURNAL; SOCIAL BEHAVIOR; SUBSTANCE ABUSE;

ALCOHOLISM; HUMANS; IMPULSIVE BEHAVIOR; REWARD;

EID: 79952544237     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2011.02.002     Document Type: Note

References (8)

1. Robinson TE, Berridge KC (2003): Addiction. Annu Rev Psychol 54:25-53. (Pubitemid 37417487)
2. Volkow ND, Wang GJ, Fowler JS, Logan J, Gatley SJ, Gifford A, et al. (1999): Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels. Am J Psychiatry 156:1440-1443. (Pubitemid 29416545)
3. Blum K, Sheridan PJ, Wood RC, Braverman ER, Chen TJ, Cull JG, Comings DE (1996): The D2 dopamine receptor gene as a determinant of reward deficiency syndrome. J R Soc Med 89:396-400. (Pubitemid 26245635)
4. Verdejo-Garcia A, Lawrence AJ, Clark L (2008): Impulsivity as a vulnerability marker for substance-use disorders: Review of findings from high-risk research, problem gamblers and genetic association studies. Neurosci Biobehav Rev 32:777-810.
5. Robinson ES, Eagle DM, Mar AC, Bari A, Banerjee G, Jiang X, et al. (2008): Similar effects of the selective noradrenaline reuptake inhibitor atomoxetine on three distinct forms of impulsivity in the rat. Neuropsychopharmacology 33:1028-1037. (Pubitemid 351367544)
6. Andrews MM, Meda SA, Thomas AD, Potenza MN, Krystal JH, Worhunsky P, et al. (2011): Individuals family history positive for alcoholism show functional magnetic resonance imaging differences in reward sensitivity that are related to impulsivity factors. Biol Psychiatry 69:675-683.
7. Makris N, Oscar-Berman M, Jaffin SK, Hodge SM, Kennedy DN, Caviness VS, et al. (2008): Decreased volume of the brain reward system in alcoholism. Biol Psychiatry 64:192-202.
8. Grant BF (1998): The impact of a family history of alcoholism on the relationship between age at onset of alcohol use and DSM-IV alcohol dependence: Results from the National Longitudinal Alcohol Epidemiologic Survey. Alcohol Health Res World 22:144-147.