BMI is superior to symptoms in predicting response to proton pump inhibitor: Randomised trial in patients with upper gastrointestinal symptoms and normal endoscopy

Gut

Volumn 60, Issue 4, 2011, Pages 442-448

  Fletcher, Jonathan ^a   Derakhshan, Mohammad H ^a   Jones, Gareth Rhys ^a   Wirz, Angela A ^a   McColl, Kenneth E L ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LANSOPRAZOLE; PLACEBO;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; DEMOGRAPHY; DISEASE SEVERITY; ESOPHAGEAL PH MONITORING; ESOPHAGUS MANOMETRY; FEMALE; GASTROINTESTINAL ENDOSCOPY; GASTROINTESTINAL SYMPTOM; GLASGOW DYSPEPSIA SEVERITY SCORE; HUMAN; LOWER ESOPHAGUS SPHINCTER PRESSURE; MAJOR CLINICAL STUDY; MALE; PARALLEL DESIGN; PREDICTION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; TREATMENT RESPONSE; UPPER GASTROINTESTINAL TRACT;

ADULT; AGED; BODY MASS INDEX; DYSPEPSIA; ENDOSCOPY, GASTROINTESTINAL; ESOPHAGEAL PH MONITORING; FEMALE; GASTROESOPHAGEAL REFLUX; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; PROTON PUMP INHIBITORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 79952537917     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2010.228064     Document Type: Article

References (25)

1. Lassen AT, Pedersen FM, Bytzer P, et al. Helicobacter pylori test-and-eradicate versus prompt endoscopy for management of dyspeptic patients: a randomised trial. Lancet 2000;356:455-60. (Pubitemid 30496816)
2. Moayyedi P, Soo S, Deeks J, et al. Systematic review and economic evaluation of Helicobacter pylori eradication treatment for non-ulcer dyspepsia. Dyspepsia Review Group. BMJ 2000;321:659-64.
3. Blum AL, Arnold R, Stolte M, et al. Short course acid suppressive treatment for patients with functional dyspepsia: results depend on Helicobacter pylori status. The Frosch Study Group. Gut 2000;47:473-80.
4. Wong WM, Wong BC, Hung WK, et al. Double blind, randomised, placebo controlled study of four weeks of lansoprazole for the treatment of functional dyspepsia in Chinese patients. Gut 2002;51:502-6.
5. Talley NJ, Meineche-Schmidt V, Paré P, et al. Efficacy of omeprazole in functional dyspepsia: double-blind, randomized, placebo-controlled trials (the Bond and Opera studies). Aliment Pharmacol Ther 1998;12:1055-65. (Pubitemid 28508719)
6. Peura DA, Kovacs TO, Metz DC, et al. Lansoprazole in the treatment of functional dyspepsia: two double-blind, randomized, placebo-controlled trials. Am J Med 2004;116:740-8. (Pubitemid 38622310)
7. Bolling-Sternevald E, Lauritsen K, Aalykke C, et al. Effect of profound acid suppression in functional dyspepsia: a double-blind, randomized, placebo-controlled trial. Scand J Gastroenterol 2002;37:1395-402. (Pubitemid 36054199)
8. Farup PG, Hovde O, Torp R, et al. Patients with functional dyspepsia responding to omeprazole have a characteristic gastro-oesophageal reflux pattern. Scand J Gastroenterol 1999;34:575-9. (Pubitemid 29339210)
9. Dean BB, Gano AD Jr, Knight K, et al. Effectiveness of proton pump inhibitors in nonerosive reflux disease. Clin Gastroenterol Hepatol 2004;2:656-64. (Pubitemid 39013424)
10. Fass R, Chey WD, Zakko SF, et al. Clinical trial: the effects of the proton pump inhibitor dexlansoprazole MR on daytime and nighttime heartburn in patients with non-erosive reflux disease. Aliment Pharmacol Ther 2009;29:1261-72.
11. Moayyedi P, Delaney BC, Vakil N, et al. The efficacy of proton pump inhibitors in nonulcer dyspepsia: a systematic review and economic analysis. Gastroenterology 2004;127:1329-37. (Pubitemid 39457759)
12. Hampel H, Abraham NS, El-Serag HB. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann Intern Med 2005;143:199-211. (Pubitemid 41076753)
13. Corley DA, Kubo A. Body mass index and gastroesophageal reflux disease: a systematic review and meta-analysis. Am J Gastroenterol 2006;101:2619-28. (Pubitemid 44665262)
14. Jacobson BC, Somers SC, Fuchs CS, et al. Body-mass index and symptoms of gastroesophageal reflux in women. N Engl J Med 2006;354:2340-8. (Pubitemid 43801279)
15. El-Omar EM, Banerjee S, Wirz A, et al. The Glasgow Dyspepsia Severity Score - a tool for the global measurement of dyspepsia. Eur J Gastroenterol Hepatol 1996;8:967-71. (Pubitemid 26356598)
16. Smith AD, Gillen D, Cochran KM, et al. Dyspepsia on withdrawal of ranitidine in previously asymptomatic volunteers. Am J Gastroenterol 1999;94:1209-13. (Pubitemid 29214630)
17. Wiener GJ, Richter JE, Copper JB, et al. The symptom index: a clinically important parameter of ambulatory 24-hour esophageal pH monitoring. Am J Gastroenterol 1988;83:358-61.
18. Bolling-Sternevald E, Lauritsen K, Talley NJ, et al. Is it possible to predict treatment response to a proton pump inhibitor in functional dyspepsia? Aliment Pharmacol Ther 2003;18:117-24.
19. Bytzer P, Hansen JM, Rune S, et al. Identifying responders to acid suppression in dyspepsia using a random starting day trial. Aliment Pharmacol Ther 2000;14:1485-94.
20. Zagari RM, Law GR, Fuccio L, et al. Dyspeptic symptoms and endoscopic findings in the community: the Loiano-Monghidoro study. Am J Gastroenterol 2010;105:565-71.
21. Carlsson R, Dent J, Bolling-Sternevald E, et al. The usefulness of a structured questionnaire in the assessment of symptomatic gastroesophageal reflux disease. Scand J Gastroenterol 1998;33:1023-9. (Pubitemid 28505643)
22. Pandolfino JE, El-Serag HB, Zhang Q, et al. Obesity: a challenge to esophagogastric junction integrity. Gastroenterology 2006;130:639-49. (Pubitemid 43374513)
23. de Vries DR, van Herwaarden MA, Smout AJ, et al. Gastroesophageal pressure gradients in gastroesophageal reflux disease: relations with hiatal hernia, body mass index, and esophageal acid exposure. Am J Gastroenterol 2008;103:1349-54. (Pubitemid 351813940)
24. Wu JC, Mui LM, Cheung CM, et al. Obesity is associated with increased transient lower esophageal sphincter relaxation. Gastroenterology 2007;132:883-9. (Pubitemid 46440865)
25. Ayazi S, Hagen JA, Zehetner J, et al. The value of high-resolution manometry in the assessment of the resting characteristics of the lower esophageal sphincter. J Gastrointest Surg 2009;13:2113-20.