Selectivity of ligand-binding assays in relationship to the measurement of biologics: How much does it matter?

Bioanalysis

Volumn 2, Issue 9, 2010, Pages 1525-1530

  Hill, Howard ^a  

^a Huntingdon Life Sciences ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; ALBIGLUTIDE; BEVACIZUMAB; DRUG METABOLITE; INFLIXIMAB; PEGINTERFERON ALPHA2A; RECOMBINANT ERYTHROPOIETIN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RITUXIMAB; TRASTUZUMAB; LIGAND;

ANALYTIC METHOD; BINDING ASSAY; BIOLOGICAL ACTIVITY; BIOLOGICAL THERAPY; DRUG CROSS REACTIVITY; DRUG DEGRADATION; DRUG DESIGN; DRUG EFFECT; DRUG HALF LIFE; DRUG MECHANISM; DRUG POTENCY; DRUG RESEARCH; DRUG SAFETY; DRUG SELECTIVITY; DRUG STABILITY; HUMAN; LIGAND BINDING; LIQUID CHROMATOGRAPHY; MACROMOLECULE; MASS SPECTROMETRY; MICROCHIP ANALYSIS; NONHUMAN; PHYSICAL CHEMISTRY; PROCESS DEVELOPMENT; PROTEIN DEGRADATION; RECOMBINANT DNA TECHNOLOGY; REVIEW; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VALIDATION PROCESS; ANIMAL; CHEMICAL ANALYSIS; CHEMISTRY; EDITORIAL; ENZYME SPECIFICITY; METABOLISM; METHODOLOGY; PHARMACOKINETICS; SENSITIVITY AND SPECIFICITY;

ANIMALS; CHEMISTRY TECHNIQUES, ANALYTICAL; HUMANS; LIGANDS; MACROMOLECULAR SUBSTANCES; PHARMACOKINETICS; SENSITIVITY AND SPECIFICITY; SUBSTRATE SPECIFICITY;

EID: 79952523987     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.10.112     Document Type: Review

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