Single-nucleotide polymorphisms in the KCNN3 gene associate with preterm birth

Reproductive Sciences

Volumn 18, Issue 3, 2011, Pages 286-295

  Day, Lori J ^a   Schaa, Kendra L ^a   Ryckman, Kelli K ^a   Cooper, Meg ^b   Dagle, John M ^a   Fong, Chin To ^c   Simhan, Hyagriv N ^d   Merrill, David C ^e   Marazita, Mary L ^b   Murray, Jeffrey C ^a   England, Sarah K ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

^e WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Ion channel; KCNN3; Preterm birth; SK3

Indexed keywords

DNA; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL;

ARTICLE; CONTROLLED STUDY; FEMALE; FISHER EXACT TEST; GENE; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; INFANT; KCNN3 GENE; MAJOR CLINICAL STUDY; PREMATURE LABOR; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

DNA; FEMALE; GENOTYPE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; PREMATURE BIRTH; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS;

EID: 79952517220     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719110391277     Document Type: Article

References (30)

1. Simhan HN, Caritis SN. Prevention of preterm delivery. N Engl J Med. 2007;357(5):477-487.
2. Boyd HA, Poulsen G, Wohlfahrt J, Murray JC, Feenstra B, Melbye M. Maternal contributions to preterm delivery. Am J Epidemiol. 2009;170(11):1358- 1364.
3. + channels depresses phasic uterine contraction. Am J Physiol Cell Physiol. 2007;292(2):C832-C840.
4. + channels in human myometrium during pregnancy and labour. Proc Biol Sci. 1993;251(1330):9-15.
5. Brainard AM, Korovkina VP, England SK. Potassium channels and uterine function. Semin Cell Dev Biol. 2007;18(3):332-339. (Pubitemid 47211988)
6. Kimura T, Ogita K, Kusui C, Ohashi K, Azuma C, Murata Y. What knockout mice can tell us about parturition. Rev Reprod. 1999;4(2):73-80. (Pubitemid 29245931)
7. + channel, ROMK. Proc Soc Exp Biol Med. 1997;216(1):57-64.
8. Mitchell BF, Taggart MJ. Are animal models relevant to key aspects of human parturition? Am J Physiol Regul Integr Comp Physiol. 2009;297(3):R525- R545.
9. Pierce SL, Kresowik JD, Lamping KG, England SK. Overexpression of SK3 channels dampens uterine contractility to prevent preterm labor in mice. Biol Reprod. 2008;78(6):1058-1063. (Pubitemid 351749302)
10. Mazzone JN, Kaiser RA, Buxton IL. Calcium-activated potassium channel expression in human myometrium: effect of pregnancy. Proc West Pharmacol Soc. 2002;45:184-186.
11. Horvath S, Xu X, Laird NM. The family based association test method: strategies for studying general genotype - phenotype associations. Eur J Hum Genet. 2001;9(4):301-306. (Pubitemid 32366699)
12. Laird NM, Horvath S, Xu X. Implementing a unified approach to family-based tests of association. Genet Epidemiol. 2000;19(suppl 1):S36-S42.
13. Rabinowitz D, Laird N. A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Hum Hered. 2000;50(4):211-223. (Pubitemid 30232624)
14. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81(3):559-575. (Pubitemid 47330214)
15. + channel subunit, SK3. Science. 2000;289(5486):1942-1946.
16. Pierce SL, Kutschke W, Cabeza R, England SK. In vivo measurement of intrauterine pressure by telemetry: a new approach for studying parturition in mouse models. Physiol Genomics. 2010;42(2):310-316.
17. Pierce SL, England SK. SK3 channel expression during pregnancy is regulated through estrogen and Sp factor-mediated transcriptional control of the KCNN3 gene. Am J Physiol Endocrinol Metab. 2010;299(4):E640-E646.
18. Ellinor PT, Lunetta KL, Glazer NL, et al. Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet. 2010;42(3):240-244.
19. Kolski-Andreaco A, Tomita H, Shakkottai VG, et al. SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels. J Biol Chem. 2004;279(8):6893-6904. (Pubitemid 38248832)
20. Lunde A, Melve KK, Gjessing HK, Skjaerven R, Irgens LM. Genetic and environmental influences on birth weight, birth length, head circumference, and gestational age by use of population-based parent-offspring data. Am J Epidemiol. 2007;165(7):734-741. (Pubitemid 46434610)
21. Oldenhof AD, Shynlova OP, Liu M, Langille BL, Lye SJ. Mitogen-activated protein kinases mediate stretch-induced c-fos mRNA expression in myometrial smooth muscle cells. Am J Physiol Cell Physiol. 2002;283(5):C1530-C1539. (Pubitemid 35178445)
22. Shynlova OP, Oldenhof AD, Liu M, Langille L, Lye SJ. Regulation of c-fos expression by static stretch in rat myometrial smooth muscle cells. Am J Obstet Gynecol. 2002;186(6):1358-1365. (Pubitemid 34665084)
23. Sooranna SR, Engineer N, Loudon JA, Terzidou V, Bennett PR, Johnson MR. The mitogen-activated protein kinase dependent expression of prostaglandin H synthase-2 and interleukin-8 messenger ribonucleic acid by myometrial cells: the differential effect of stretch and interleukin-1fbetag. J Clin Endocrinol Metab. 2005;90(6):3517-3527. (Pubitemid 41014322)
24. Sooranna SR, Lee Y, Kim LU, Mohan AR, Bennett PR, Johnson MR. Mechanical stretch activates type 2 cyclooxygenase via activator protein-1 transcription factor in human myometrial cells. Mol Hum Reprod. 2004;10(2):109-113. (Pubitemid 38196512)
25. Loudon JA, Sooranna SR, Bennett PR, Johnson MR. Mechanical stretch of human uterine smooth muscle cells increases IL-8 mRNA expression and peptide synthesis. Mol Hum Reprod. 2004;10(12):895-899. (Pubitemid 40045312)
26. Terzidou V, Sooranna SR, Kim LU, Thornton S, Bennett PR, Johnson MR. Mechanical stretch up-regulates the human oxytocin receptor in primary human uterine myocytes. J Clin Endocrinol Metab. 2005;90(1):237-246. (Pubitemid 40116664)
27. Dalrymple A, Mahn K, Poston L, Songu-Mize E, Tribe RM. Mechanical stretch regulates TRPC expression and calcium entry in human myometrial smooth muscle cells. Mol Hum Reprod. 2007;13(3):171-179.
28. + channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum. Naunyn Schmiedebergs Arch Pharmacol. 2004;369(6):602-615.
29. Blanks AM, Thornton S. The role of oxytocin in parturition. BJOG. 2003;110(suppl 20):46-51. (Pubitemid 36581875)
30. Armstrong WE, Rubrum A, Teruyama R, Bond CT, Adelman JP. Immunocytochemical localization of small-conductance, calcium-dependent potassium channels in astrocytes of the rat supraoptic nucleus. J Comp Neurol. 2005;491(3):175-185. (Pubitemid 41324590)