Renal effects of the novel selective adenosine A1 receptor blocker SLV329 in experimental liver cirrhosis in rats

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Hocher, Berthold ^a,b   Heiden, Susi ^b   von Websky, Karoline ^a,b   Arafat, Ayman M ^c,d   Rahnenführer, Jan ^a,b   Alter, Markus ^b,c   Kalk, Philipp ^b,c   Ziegler, Dieter ^e   Fischer, Yvan ^e   Pfab, Thiemo ^b,c  

^a UNIVERSITY OF POTSDAM   (Germany)

^b DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^e ABBOTT GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE RECEPTOR; DIURETIC AGENT; FUROSEMIDE; SLV 329; THIOACETAMIDE; UNCLASSIFIED DRUG; ADENOSINE A1 RECEPTOR; CREATININE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PYRIMIDINE; PYRIMIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CREATININE CLEARANCE; DIURESIS; DIURETIC ACTIVITY; DRUG EFFECT; DRUG MECHANISM; GLOMERULUS FILTRATION RATE; KIDNEY FUNCTION; KIDNEY STRUCTURE; LIVER CIRRHOSIS; LIVER FIBROSIS; LONG TERM CARE; MALE; MORTALITY; NONHUMAN; PROTEIN EXPRESSION; RAT; RECEPTOR BLOCKING; SODIUM EXCRETION; TREATMENT DURATION; URINARY EXCRETION; WISTAR RAT; ANIMAL; BLOOD; DOSE RESPONSE; EXPERIMENTAL LIVER CIRRHOSIS; IMMUNOBLOTTING; KAPLAN MEIER METHOD; KIDNEY; KIDNEY FUNCTION TEST; METABOLISM; PATHOPHYSIOLOGY; URINE;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

ADENOSINE A1 RECEPTOR ANTAGONISTS; ANIMALS; CREATININE; DOSE-RESPONSE RELATIONSHIP, DRUG; IMMUNOBLOTTING; KAPLAN-MEIER ESTIMATE; KIDNEY; KIDNEY FUNCTION TESTS; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PYRIMIDINES; RATS; RATS, WISTAR; RECEPTOR, ADENOSINE A1; THIOACETAMIDE;

EID: 79952516357     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017891     Document Type: Article

References (33)

1. Gines P, Schrier RW, (2009) Renal failure in cirrhosis. N Engl J Med 361: 1279-1290.
2. Linden J, (2001) Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection. Annu Rev Pharmacol Toxicol 41: 775-787.
3. Ming Z, Smyth DD, Lautt WW, (2002) Decreases in portal flow trigger a hepatorenal reflex to inhibit renal sodium and water excretion in rats: role of adenosine. Hepatology 35: 167-175.
4. Ming Z, Smyth DD, Lautt WW, (2002) Decreases in portal flow trigger a hepatorenal reflex to inhibit renal sodium and water excretion in rats: role of adenosine. Hepatology 35: 167-175.
5. Ming Z, Lautt WW, (2006) Intrahepatic adenosine-mediated activation of hepatorenal reflex is via A1 receptors in rats. Can J Physiol Pharmacol 84: 1177-1184.
6. Jackson EK, Zhu C, Tofovic SP, (2002) Expression of adenosine receptors in the preglomerular microcirculation. Am J Physiol Renal Physiol 283: F41-F51.
7. Wilcox CS, Welch WJ, Schreiner GF, Belardinelli L, (1999) Natriuretic and diuretic actions of a highly selective adenosine A1 receptor antagonist. J Am Soc Nephrol 10: 714-720.
8. Vallon V, Muhlbauer B, Osswald H, (2006) Adenosine and kidney function. Physiol Rev 86: 901-940.
9. Gottlieb SS, Brater DC, Thomas I, Havranek E, Bourge R, et al. (2002) BG9719 (CVT-124), an A1 adenosine receptor antagonist, protects against the decline in renal function observed with diuretic therapy. Circulation 105: 1348-1353.
10. Ming Z, Fan YJ, Yang X, Lautt WW, (2005) Blockade of intrahepatic adenosine receptors improves urine excretion in cirrhotic rats induced by thioacetamide. J Hepatol 42: 680-686.
11. Miracle CM, Rieg T, Blantz RC, Vallon V, Thomson SC, (2007) Combined effects of carbonic anhydrase inhibitor and adenosine A1 receptor antagonist on hemodynamic and tubular function in the kidney. Kidney Blood Press Res 30: 388-399.
12. Wilcox CS, Welch WJ, Schreiner GF, Belardinelli L, (1999) Natriuretic and diuretic actions of a highly selective adenosine A1 receptor antagonist. J Am Soc Nephrol 10: 714-720.
13. Knight RJ, Bowmer CJ, Yates MS, (1993) The diuretic action of 8-cyclopentyl-1,3-dipropylxanthine, a selective A1 adenosine receptor antagonist. Br J Pharmacol 109: 271-277.
14. Vallon V, Muhlbauer B, Osswald H, (2006) Adenosine and kidney function. Physiol Rev 86: 901-940.
15. Wilcox CS, Welch WJ, Schreiner GF, Belardinelli L, (1999) Natriuretic and diuretic actions of a highly selective adenosine A1 receptor antagonist. J Am Soc Nephrol 10: 714-720.
16. Vallon V, Muhlbauer B, Osswald H, (2006) Adenosine and kidney function. Physiol Rev 86: 901-940.
17. Jackson EK, Mi Z, Dubey RK, (2007) The extracellular cAMP-adenosine pathway significantly contributes to the in vivo production of adenosine. J Pharmacol Exp Ther 320: 117-123.
18. Stanley AJ, Forrest EH, Dabos K, Bouchier IA, Hayes PC, (1998) Natriuretic effect of an adenosine-1 receptor antagonist in cirrhotic patients with ascites. Gastroenterology 115: 406-411.
19. Toya Y, Umemura S, Iwamoto T, Hirawa N, Kihara M, et al. (1993) Identification and characterization of adenosine A1 receptor-cAMP system in human glomeruli. Kidney Int 43: 928-932.
20. Ming Z, Fan YJ, Yang X, Lautt WW, (2005) Blockade of intrahepatic adenosine receptors improves urine excretion in cirrhotic rats induced by thioacetamide. J Hepatol 42: 680-686.
21. Stanley AJ, Forrest EH, Dabos K, Bouchier IA, Hayes PC, (1998) Natriuretic effect of an adenosine-1 receptor antagonist in cirrhotic patients with ascites. Gastroenterology 115: 406-411.
22. Reyes AJ, (1993) Renal excretory profiles of loop diuretics: consequences for therapeutic application. J Cardiovasc Pharmacol 22 (Suppl 3): S11-S23.
23. Chan ES, Montesinos MC, Fernandez P, Desai A, Delano DL, et al. (2006) Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis. Br J Pharmacol 148: 1144-1155.
24. Ming Z, Smyth DD, Lautt WW, (2002) Decreases in portal flow trigger a hepatorenal reflex to inhibit renal sodium and water excretion in rats: role of adenosine. Hepatology 35: 167-175.
25. Ming Z, Lautt WW, (2006) Intrahepatic adenosine-mediated activation of hepatorenal reflex is via A1 receptors in rats. Can J Physiol Pharmacol 84: 1177-1184.
26. Sansoe G, Silvano S, Mengozzi G, Smedile A, Touscoz G, et al. (2005) Loss of tubuloglomerular feedback in decompensated liver cirrhosis: physiopathological implications. Dig Dis Sci 50: 955-963.
27. Hocher B, (2010) Adenosine A1 receptor antagonists in clinical research and development. Kidney Int 78: 438-445.
28. Hocher B, (2010) Adenosine A1 receptor antagonists in clinical research and development. Kidney Int 78: 438-445.
29. Kalk P, Eggert B, Relle K, Godes M, Heiden S, et al. (2007) The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure. Br J Pharmacol 151: 1025-1032.
30. Ikejima K, Takei Y, Honda H, Hirose M, Yoshikawa M, et al. (2002) Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat. Gastroenterology 122: 1399-1410.
31. Quaschning T, Voss F, Relle K, Kalk P, Vignon-Zellweger N, et al. (2007) Lack of endothelial nitric oxide synthase promotes endothelin-induced hypertension: lessons from endothelin-1 transgenic/endothelial nitric oxide synthase knockout mice. J Am Soc Nephrol 18: 730-740.
32. Pfab T, Thone-Reineke C, Theilig F, Lange I, Witt H, et al. (2006) Diabetic endothelin B receptor-deficient rats develop severe hypertension and progressive renal failure. J Am Soc Nephrol 17: 1082-1089.
33. Jackson EK, Zhu C, Tofovic SP, (2002) Expression of adenosine receptors in the preglomerular microcirculation. Am J Physiol Renal Physiol 283: F41-F51.