Clinical significance of macroscopic completeness of mesorectal resection in rectal cancer

Colorectal Disease

Volumn 13, Issue 4, 2011, Pages 381-386

  Leite, J S ^a   Martins, S C ^a   Oliveira, J ^a   Cunha, M F ^b   Castro Sousa, F ^a  

^a Department of Surgery III ^*  (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Disease free survival; Local recurrence; Mesorectal grades; Prognostic factors; Rectal cancer

Indexed keywords

ADULT; AGED; ARTICLE; CANCER RECURRENCE; CANCER STAGING; CHEMORADIOTHERAPY; DISEASE FREE SURVIVAL; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECTUM CANCER; RECTUM RESECTION; TREATMENT OUTCOME;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RECTAL NEOPLASMS; RISK FACTORS; TREATMENT OUTCOME;

EID: 79952509676     PISSN: 14628910     EISSN: 14631318     Source Type: Journal    
DOI: 10.1111/j.1463-1318.2009.02153.x     Document Type: Article

References (18)

1. Nagtegaal ID, van de Velde CJ, van der Worp E, Kapiteijn E, Quirke P, van Krieken JH. Macroscopic evaluation of rectal cancer resection specimen: clinical significance of the pathologist in quality control. J Clin Oncol 2002; 20: 1729-34.
2. Heald RJ, Husband EM, Ryall RD. The mesorectum in rectal cancer surgery - the clue to pelvic recurrence? Br J Surg 1982; 69: 613-6.
3. Kapiteijn E, Marijnen CA, Nagtegaal ID et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 2001; 345: 638-46.
4. Wibe A, Rendedal PR, Svensson E, Norstein J, Eide TJ, Myrvold HE, Søreide O. Prognostic significance of the circumferencial resection margin following total mesorectal excision for rectal cancer. Br J Surg 2002; 89: 327-34.
5. Peeters KCMJ, Marijnen CAM, Nagtgaal ID, et al. The TME trial after a median follow-up of 6years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg 2007; 246: 693-701.
6. Birbeck KF, Macklin CP, Tiffin NJ et al. Rates of circumferential resection margin involvement vary between surgeons and predict outcomes in rectal surgery. Ann Surg 2002; 235: 449-57.
7. Nagtegaal ID, Gosens JEM, Marijnen CAM, Rutten HJ, van de Velde CJ, van Krieken JH. Combinations of tumor and treatment parameters are more discriminative for prognosis than the present TNM system in rectal cancer. J Clin Oncol 2007; 25: 1647-50.
8. Nagtegaal ID, Quirke P. What is the role for the circumferential margin in the modern treatment of rectal cancer? J Clin Oncol 2008; 26: 303-12.
9. Quirke P, Durdey P, Dixon MF, Willliams NS. Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathologic study of lateral tumour spread and surgical excision. Lancet 1986; 2: 996-9.
10. Maslekar S, Sharma A, MacDonald A, Gunn J, Monson JR, Hartley JE. Mesorectal grades predict recurrences after curative resection for rectal cancer. Dis Colon Rectum 2007; 50: 168-75.
11. Wibe A, Syse A, Andersen E, Tretli S, Myrvold HE, Søreide O, Norwegian Rectal Cancer Group. Oncological outcomes after total mesorectal excision for cure for cancer of the lower rectum: anterior vs abdominoperineal resection. Dis Colon Rectum 2004; 47: 48-58.
12. Tekkis PP, Heriot AG, Smith J, Thompson MR, Finan P, Stamatakis JD; Association of Coloproctology of Great Britain and Ireland. Comparision of circumferencial margin involvement between restorative and nonrestorative resections for rectal cancer. Colorectal Dis 2005; 7: 369-74.
13. Holm T, Ljung A, Häggmark T, Jurell G, Lagergren J. Extended abdominoperineal resection with gluteous maximus flap reconstrution of the pelvic floor for rectal cancer. Br J Surg 2007; 94: 232-8.
14. Gosens MJEM, Van Krieken JH, Rutten H et al. A critical appraisal of therapy induced tumor regression in rectal carcinoma. Ann Oncol 2006; 17: 62.
15. Ryan R, Gibbons D, Hyland JM, Treanor D, White A, Mulcahy HE, O'Donoghue DP, Moriarty M, Fennelly D, Sheahan K. Pathological response following long-course neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Histhopathology 2005; 47: 141-6.
16. Leite J, Monteiro A, Martins M et al. Prognostic value of pathological TNM staging and tumour regression grade in rectal cancer after preoperative radiotherapy. Colorectal Dis 2006; 8(Suppl 4): 14.
17. Das P, Skibber JM, Rodriguez-Bigas MA et al. Clinical and pathologic predictors of locoregional recurrence, distant metastasis, and overall survival in patients treated with chemoradiation and mesorectal excision for rectal cancer. Am J Clin Oncol 2006; 29: 219-24.
18. Kim NK, Baik SH, Seong JS, Kim H, Roh JK, Lee KY, Sohn SK, Cho CH. Oncologic outcomes after neoadjuvant chemoradiation followed by curative resection with tumor-specific mesorectal excision for fixed locally advanced rectal cancer: impact of postirradiated pathologic downstaging on local recurrence and survival. Ann Surg 2006; 244: 1024-30.