Validity and power of association testing in family-based sampling designs: Evidence for and against the common wisdom

Genetic Epidemiology

Volumn 35, Issue 3, 2011, Pages 174-181

  Knight, Stacey ^a   Camp, Nicola J ^a  

^a Genetic Epidemiology Group   (United States)

Author keywords

Association tests; Case and control selection; Family based designs; Power

Indexed keywords

ARTICLE; FAMILY; GENETIC ASSOCIATION; HUMAN; MODIFIED QUASI LIKELIHOOD SCORE; NUCLEAR FAMILY; PEDIGREE; POWER ANALYSIS; SAMPLING; SCORING SYSTEM; SIMULATION; STATISTICAL ANALYSIS; THEORETICAL STUDY; VALIDITY;

ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; FAMILY; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LIKELIHOOD FUNCTIONS; MALE; MODELS, GENETIC; MODELS, STATISTICAL; MOLECULAR EPIDEMIOLOGY; PEDIGREE; REPRODUCIBILITY OF RESULTS;

EID: 79952501988     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.20565     Document Type: Article

References (21)

1. Allen-Brady K, Wong J, Camp NJ. 2006. PedGenie: an analysis approach for genetic association testing in extended pedigrees and genealogies of arbitrary size. BMC Bioinformatics 7:209.
2. Bourgain C, Hoffjan S, Nicolae R, Newman D, Steiner L, Walker K, Reynolds R, Ober C, McPeek MS. 2003. Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus. Am J Hum Genet 73:612-626.
3. Browning SR, Briley JD, Briley LP, Chandra G, Charnecki JH, Ehm MG, Johansson KA, Jones BJ, Karter AJ, Yarnall DP, Wagner MJ. 2005. Case-control single-marker and haplotypic association analysis of pedigree data. Genet Epidemiol 28:110-122.
4. Bucher K, Schrott H. 1982. The effects of nonrandom sampling of familial correlation. Biometrics 38:249-253.
5. Cupples LA, Arruda HT, Benjamin EJ, D'Agostino Sr RB, Demissie S, DeStefano AL, Dupuis J, Falls KM, Fox CS, Gottlieb DJ, Govindaraju DR, Guo CY, Heard-Costa NL, Hwang SJ, Kathiresan S, Kiel DP, Laramie JM, Larson MG, Levy D, Liu CY, Lunetta KL, Mailman MD, Manning AK, Meigs JB, Murabito JM, Newton-Cheh C, O'connor GT, O'Donnell CJ, Pandey M, Seshadri S, Vasan RS, Wang ZY, Wilk JB, Wolf PA, Yang Q, Atwood LD. 2007. The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. BMC Med Genet 8:S1.
6. Fingerlin TE, Boehnke M, Abecasis GR. 2004. Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information. Am J Hum Genet 74:432-443.
7. Knight S, Abo RP, Wong J, Thomas A, Camp NJ. 2009. Pedigree association: assigning individual weights to pedigree-members for genetic association analysis. BMC Proc 3:S121.
8. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. 1996. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58:1347-1363.
9. Li C, editor. 1955. Population Genetics. Chicago: University of Chicago Press.
10. Li M, Boehnke M, Abecasis GR. 2006. Efficient study designs for test of genetic association using sibship data and unrelated cases and controls. Am J Hum Genet 78:778-792.
11. McArdle PF, O'Connell JR, Pollin TI, Baumgarten M, Shuldiner AR, Peyser PA, Mitchell BD. 2007. Accounting for relatedness in family based genetic association studies. Hum Hered 64:234-242.
12. Moore RM, Pinel T, Zhao JH, March R, Jawaid A. 2005. Selecting cases from nuclear families for case-control association analysis. BMC Genet 6:S105.
13. Newman DL, Abney M, McPeek MS, Ober C, Cox NJ. 2001. The importance of genealogy in determining genetic associations with complex traits. Am J Hum Genet 69:1146-1148.
14. Ober CL, Martin AO, Simpson JL, Hauck WW, Amos DB, Kostyu DD, Fotino M, Allen Jr FH. 1983. Shared HLA antigens and reproductive performance among Hutterites. Am J Hum Genet 35:994-1004.
15. Rabinowitz D, Laird N. 2000. A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Hum Hered 50:211-223.
16. Slager SL, Schaid DJ. 2001. Evaluation of candidate genes in case-control studies: a statistical method to account for related subjects. Am J Hum Genet 68:1457-1462.
17. Slager SL, Schaid DJ, Wang L, Thibodeau SN. 2003. Candidate-gene association studies with pedigree data: controlling for environmental covariates. Genet Epidemiol 24:273-283.
18. Spielman RS, McGinnis RE, Ewens WJ. 1993. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516.
19. Thornton T, McPeek MS. 2007. Case-control association testing with related individuals: a more powerful quasi-likelihood score test. Am J Hum Genet 81:321-337.
20. Tian X, Joo J, Wu CO, Lin JP. 2007. Comparing strategies for evaluation of candidate genes in case-control studies using family data. BMC Proc 1:S31.
21. Witte JS, Gauderman WJ, Thomas DC. 1999. Asymptotic bias and efficiency in case-control studies of candidate genes and gene-environment interactions: basic family designs. Am J Epidemiol 149:693-705.