Is bone marrow another target of diabetic complications?

European Journal of Clinical Investigation

Volumn 41, Issue 4, 2011, Pages 457-463

  Fadini, Gian Paolo ^a  

^a UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD133 ANTIGEN; CHEMOKINE RECEPTOR CXCR4;

BONE MARROW DISEASE; COMPLICATION; CONGENITAL DISORDER; DIABETES MELLITUS; DIAGNOSIS; HUMAN; NOTE; PRIORITY JOURNAL; STEM CELL; SURGERY; THERAPY;

ANIMALS; BONE MARROW; BONE MARROW DISEASES; DIABETES COMPLICATIONS; HOMEOSTASIS; HUMANS; RATS;

EID: 79952498479     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2010.02417.x     Document Type: Note

References (64)

1. Morgagni JB, De sedibus et causis morborum per anatomen indagatis., Ex Latina Ant. G. Demonville Typographia, 1761.
2. Fang B, Shi M, Liao L, Yang S, Liu Y, Zhao RC. Multiorgan engraftment and multilineage differentiation by human fetal bone marrow Flk1+/CD31-/CD34- progenitors. J Hematother Stem Cell Res 2003;12:603-13.
3. Miyawaki A. Green fluorescent protein glows gold. Cell 2008;135:987-90.
4. Manfra DJ, Chen SC, Yang TY, Sullivan L, Wiekowski MT, Abbondanzo S et al. Leukocytes expressing green fluorescent protein as novel reagents for adoptive cell transfer and bone marrow transplantation studies. Am J Pathol 2001;158:41-7.
5. Tepper OM, Galiano RD, Kalka C, Gurtner GC. Endothelial progenitor cells: the promise of vascular stem cells for plastic surgery. Plast Reconstr Surg 2003;111:846-54.
6. Xu Y, Arai H, Zhuge X, Sano H, Murayama T, Yoshimoto M et al. Role of bone marrow-derived progenitor cells in cuff-induced vascular injury in mice. Arterioscler Thromb Vasc Biol 2004;24:477-82.
7. Ikarashi K, Li B, Suwa M, Kawamura K, Morioka T, Yao J et al. Bone marrow cells contribute to regeneration of damaged glomerular endothelial cells. Kidney Int 2005;67:1925-33.
8. Bilic-Curcic I, Kalajzic Z, Wang L, Rowe DW. Origins of endothelial and osteogenic cells in the subcutaneous collagen gel implant. Bone 2005;37:678-87.
9. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001;410:701-5.
10. Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001;105:369-77.
11. Quaini F, Urbanek K, Beltrami AP, Finato N, Beltrami CA, Nadal-Ginard B et al. Chimerism of the transplanted heart. N Engl J Med 2002;346:5-15.
12. van Poelgeest EP, Baelde HJ, Lagaaij EL, Sijpkens YW, de Heer E, Bruijn JA et al. Endothelial cell chimerism occurs more often and earlier in female than in male recipients of kidney transplants. Kidney Int 2005;68:847-53.
13. Spencer H, Rampling D, Aurora P, Bonnet D, Hart SL, Jaffe A. Transbronchial biopsies provide longitudinal evidence for epithelial chimerism in children following sex mismatched lung transplantation. Thorax 2005;60:60-2.
14. Spyridonidis A, Schmitt-Graff A, Tomann T, Dwenger A, Follo M, Behringer D et al. Epithelial tissue chimerism after human hematopoietic cell transplantation is a real phenomenon. Am J Pathol 2004;164:1147-55.
15. Wagers AJ, Sherwood RI, Christensen JL, Weissman IL. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 2002;297:2256-9.
16. Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M et al. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 2003;422:897-901.
17. Reinecke H, Minami E, Zhu WZ, Laflamme MA. Cardiogenic differentiation and transdifferentiation of progenitor cells. Circ Res 2008;103:1058-71.
18. Murry CE, Soonpaa MH, Reinecke H, Nakajima H, Nakajima HO, Rubart M et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 2004;428:664-8.
19. Deb A, Patterson C. Hard luck stories: the reality of endothelial progenitor cells continues to fall short of the promise. Circulation 2010;121:850-2.
20. Takahashi T, Kalka C, Masuda H, Chen D, Silver M, Kearney M et al. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med 1999;5:434-8.
21. Fadini GP, Baesso I, Albiero M, Sartore S, Agostini C, Avogaro A. Technical notes on endothelial progenitor cells: ways to escape from the knowledge plateau. Atherosclerosis 2008;197:496-503.
22. Cesselli D, Beltrami AP, Rigo S, Bergamin N, D'Aurizio F, Verardo R et al. Multipotent progenitor cells are present in human peripheral blood. Circ Res 2009;104:1225-34.
23. Wojakowski W, Tendera M, Michalowska A, Majka M, Kucia M, Maslankiewicz K et al. Mobilization of CD34/CXCR4+, CD34/CD117+, c-met+stem cells, and mononuclear cells expressing early cardiac, muscle, and endothelial markers into peripheral blood in patients with acute myocardial infarction. Circulation 2004;110:3213-20.
24. Yeh E, Zhang S, Wu H, Korbling M, Willerson J, Estrov Z. Transdifferentiation of human peripheral blood CD34+-enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivo. Circulation 2003;108:2070-3.
25. Popa ER, Harmsen MC, Tio RA, van der Strate BW, Brouwer LA, Schipper M et al. Circulating CD34+ progenitor cells modulate host angiogenesis and inflammation in vivo. J Mol Cell Cardiol 2006;41:86-96.
26. Fadini GP, Agostini C, Sartore S, Avogaro A. Endothelial progenitor cells in the natural history of atherosclerosis. Atherosclerosis 2007;194:46-54.
27. Leor J, Marber M. Endothelial progenitors: a new Tower of Babel? J Am Coll Cardiol 2006;48:1588-90.
28. Madeddu P, Emanueli C, Pelosi E, Salis MB, Cerio AM, Bonanno G et al. Transplantation of low dose CD34+KDR+ cells promotes vascular and muscular regeneration in ischemic limbs. FASEB J 2004;18:1737-9.
29. Guven H, Shepherd RM, Bach RG, Capoccia BJ, Link DC. The number of endothelial progenitor cell colonies in the blood is increased in patients with angiographically significant coronary artery disease. J Am Coll Cardiol 2006;48:1579-87.
30. Hagensen MK, Shim J, Thim T, Falk E, Bentzon JF. Circulating endothelial progenitor cells do not contribute to plaque endothelium in murine atherosclerosis. Circulation 2010;121:898-905.
31. Yoder MC, Mead LE, Prater D, Krier TR, Mroueh KN, Li F et al. Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood 2007;109:1801-9.
32. Heil M, Ziegelhoeffer T, Mees B, Schaper W. A different outlook on the role of bone marrow stem cells in vascular growth: bone marrow delivers software not hardware. Circ Res 2004;94:573-4.
33. Fantin A, Vieira JM, Gestri G, Denti L, Schwarz Q, Prykhozhij S et al. Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction. Blood 2010;116:829-40.
34. Fadini GP, Sartore S, Agostini C, Avogaro A. Significance of endothelial progenitor cells in subjects with diabetes. Diabetes Care 2007;30:1305-13.
35. Fadini GP, Miorin M, Facco M, Bonamico S, Baesso I, Grego F et al. Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus. J Am Coll Cardiol 2005;45:1449-57.
36. Fadini GP, Sartore S, Albiero M, Baesso I, Murphy E, Menegolo M et al. Number and function of endothelial progenitor cells as a marker of severity for diabetic vasculopathy. Arterioscler Thromb Vasc Biol 2006;26:2140-6.
37. Fadini GP, Pucci L, Vanacore R, Baesso I, Penno G, Balbarini A et al. Glucose tolerance is negatively associated with circulating progenitor cell levels. Diabetologia 2007;50:2156-63.
38. Egan CG, Lavery R, Caporali F, Fondelli C, Laghi-Pasini F, Dotta F et al. Generalised reduction of putative endothelial progenitors and CXCR4-positive peripheral blood cells in type 2 diabetes. Diabetologia 2008;51:1296-305.
39. Loomans CJ, de Koning EJ, Staal FJ, Rookmaaker MB, Verseyden C, de Boer HC et al. Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes 2004;53:195-9.
40. Sibal L, Aldibbiat A, Agarwal SC, Mitchell G, Oates C, Razvi S et al. Circulating endothelial progenitor cells, endothelial function, carotid intima-media thickness and circulating markers of endothelial dysfunction in people with type 1 diabetes without macrovascular disease or microalbuminuria. Diabetologia 2009;52:1464-73.
41. Fadini GP. An underlying principle for the study of circulating progenitor cells in diabetes and its complications. Diabetologia 2008;51:1091-4.
42. Fadini GP, Sartore S, Baesso I, Lenzi M, Agostini C, Tiengo A et al. Endothelial progenitor cells and the diabetic paradox. Diabetes Care 2006;29:714-6.
43. Fadini GP, de Kreutzenberg SV, Coracina A, Baesso I, Agostini C, Tiengo A et al. Circulating CD34+ cells, metabolic syndrome, and cardiovascular risk. Eur Heart J 2006;27:2247-55.
44. Minamino T, Komuro I. Vascular aging: insights from studies on cellular senescence, stem cell aging, and progeroid syndromes. Nat Clin Pract Cardiovasc Med 2008;5:637-48.
45. Loomans CJ, van Haperen R, Duijs JM, Verseyden C, de Crom R, Leenen PJ et al. Differentiation of bone marrow-derived endothelial progenitor cells is shifted into a proinflammatory phenotype by hyperglycemia. Mol Med 2009;15:152-9.
46. Seeger FH, Haendeler J, Walter DH, Rochwalsky U, Reinhold J, Urbich C et al. p38 mitogen-activated protein kinase downregulates endothelial progenitor cells. Circulation 2005;111:1184-91.
47. Muslin AJ. MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets. Clin Sci (Lond) 2008;115:203-18.
48. Gallagher KA, Liu ZJ, Xiao M, Chen H, Goldstein LJ, Buerk DG et al. Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha. J Clin Invest 2007;117:1249-59.
49. Caballero S, Sengupta N, Afzal A, Chang KH, Li Calzi S, Guberski DL et al. Ischemic vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cells. Diabetes 2007;56:960-7.
50. Krankel N, Adams V, Linke A, Gielen S, Erbs S, Lenk K et al. Hyperglycemia reduces survival and impairs function of circulating blood-derived progenitor cells. Arterioscler Thromb Vasc Biol 2005;25:698-703.
51. Marchetti V, Menghini R, Rizza S, Vivanti A, Feccia T, Lauro D et al. Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt/FoxO signaling. Diabetes 2006;55:2231-7.
52. Fadini GP, Boscaro E, de Kreutzenberg S, Agostini C, Seeger F, Dimmeler S et al. Time course and mechanisms of circulating progenitor cell reduction in the natural history of type 2 diabetes mellitus. Diabetes Care 2010;33:1097-102.
53. Fadini GP, Sartore S, Schiavon M, Albiero M, Baesso I, Cabrelle A et al. Diabetes impairs progenitor cell mobilisation after hindlimb ischaemia-reperfusion injury in rats. Diabetologia 2006;49:3075-84.
54. Ceradini DJ, Yao D, Grogan RH, Callaghan MJ, Edelstein D, Brownlee M et al. Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice. J Biol Chem 2008;283:10930-8.
55. Avogaro A, Fadini GP, Gallo A, Pagnin E, de Kreutzenberg S. Endothelial dysfunction in type 2 diabetes mellitus. Nutr Metab Cardiovasc Dis 2006;16(Suppl 1):S39-45.
56. Aicher A, Heeschen C, Mildner-Rihm C, Urbich C, Ihling C, Technau-Ihling K et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 2003;9:1370-6.
57. Krankel N, Armstrong SP, McArdle CA, Dayan C, Madeddu P. Distinct kinin-induced functions are altered in circulating cells of young type 1 diabetic patients. PLoS ONE 2010;5:e11146.
58. Busik JV, Tikhonenko M, Bhatwadekar A, Opreanu M, Yakubova N, Caballero S et al. Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock. J Exp Med 2009;206:2897-906.
59. Katayama Y, Battista M, Kao WM, Hidalgo A, Peired AJ, Thomas SA et al. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 2006;124:407-21.
60. Oikawa A, Siragusa M, Quaini F, Mangialardi G, Katare RG, Caporali A et al. Diabetes mellitus induces bone marrow microangiopathy. Arterioscler Thromb Vasc Biol 2010;30:498-508.
61. Orlandi A, Chavakis E, Seeger F, Tjwa M, Zeiher AM, Dimmeler S. Long-term diabetes impairs repopulation of hematopoietic progenitor cells and dysregulates the cytokine expression in the bone marrow microenvironment in mice. Basic Res Cardiol 2010 in press.
62. Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 2005;54:1615-25.
63. Fadini GP, de Kreutzenberg S, Agostini C, Boscaro E, Tiengo A, Dimmeler S et al. Low CD34+ cell count and metabolic syndrome synergistically increase the risk of adverse outcomes. Atherosclerosis 2009;207:213-9.
64. Fadini GP, Boscaro E, Albiero M, Menegazzo L, Frison V, de Kreuizenberg SV et al. The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes mellitus. Possible role of stromal derived factor-1alpha. Diabetes Care 2010;33:1607-9.