2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: A structure-activity relationship study

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 7, 2011, Pages 1929-1932

  Chen, Qianyi ^a,b   Bryant, Vashti C ^a,b   Lopez, Hernando ^a   Kelly, David L ^a   Luo, Xu ^a   Natarajan, Amarnath ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Antiproliferative; Mcl 1 dependent apoptosis; Quinoxaline urea

Indexed keywords

ANTINEOPLASTIC AGENT; BISFURANYLQUINOXALINEUREA; CASPASE 3; CASPASE 7; DOXYCYCLINE; ETOPOSIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN MCL 1; QUINOXALIN 6 AMINE DERIVATIVE; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL GROWTH; CELL SURVIVAL; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; GROWTH INHIBITION; HUMAN; PROTEIN CLEAVAGE; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79952490659     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.02.055     Document Type: Article

References (19)

1. Welsch, M. E.; Snyder, S. A.; Stockwell, B. R. Curr. Opin. Chem. Biol. 2010, 14, 347.
2. Escobar-Chavez, J. J.; Merino, V.; Lopez-Cervantes, M.; Rodriguez-Cruz, I. M.; Quintanar-Guerrero, D.; Ganem-Quintanar, A. Curr. Drug Discov. Technol. 2009, 6, 171.
3. McLaughlin, M. A.; Chiou, G. C. J. Ocul. Pharmacol. 1985, 1, 101.
4. Hugo, W. B.; Stretton, R. G. Nature 1964, 202, 1217.
5. Crowe, A.; Ballatore, C.; Hyde, E.; Trojanowski, J. Q.; Lee, V. M. Biochem. Biophys. Res. Commun. 2007, 358, 1.
6. Li, J.; Chen, J.; Zhang, L.; Wang, F.; Gui, C.; Zhang, L.; Qin, Y.; Xu, Q.; Liu, H.; Nan, F.; Shen, J.; Bai, D.; Chen, K.; Shen, X.; Jiang, H. Bioorg. Med. Chem. 2006, 14, 5527.
7. Berndt, A.; Miller, S.; Williams, O.; Le, D. D.; Houseman, B. T.; Pacold, J. I.; Gorrec, F.; Hon, W. C.; Liu, Y.; Rommel, C.; Gaillard, P.; Ruckle, T.; Schwarz, M. K.; Shokat, K. M.; Shaw, J. P.; Williams, R. L. Nat. Chem. Biol. 2010, 6, 244.
8. Zhang, L.; Qiu, B.; Xiong, B.; Li, X.; Li, J.; Wang, X.; Li, J.; Shen, J. Bioorg. Med. Chem. Lett. 2007, 17, 2118.
9. Johnston, P. A.; Foster, C. A.; Tierno, M. B.; Shun, T. Y.; Shinde, S. N.; Paquette, W. D.; Brummond, K. M.; Wipf, P.; Lazo, J. S. Assay Drug Dev. Technol. 2009, 7, 250.
10. Simeonov, A.; Yasgar, A.; Jadhav, A.; Lokesh, G. L.; Klumpp, C.; Michael, S.; Austin, C. P.; Natarajan, A.; Inglese, J. Anal. Biochem. 2008, 375, 60.
11. Wang, F.; Chen, J.; Liu, X.; Shen, X.; He, X.; Jiang, H.; Bai, D. Chem. Pharm. Bull. (Tokyo) 2006, 54, 372.
12. Chinen, L. K.; Galen, K. P.; Kuan, K. T.; Dyszlewski, M. E.; Ozaki, H.; Sawai, H.; Pandurangi, R. S.; Jacobs, F. G.; Dorshow, R. B.; Rajagopalan, R. J. Med. Chem. 2008, 51, 957.
13. Kumar, E. A.; Charvet, C. D.; Lokesh, G. L.; Natarajan, A. Anal. Biochem. 2010, doi:10.1016/j.ab.2010.11.038.
14. Lokesh, G. L.; Rachamallu, A.; Kumar, G. D.; Natarajan, A. Anal. Biochem. 2006, 352, 135.
15. Joseph, P. R.; Yuan, Z.; Kumar, E. A.; Lokesh, G. L.; Kizhake, S.; Rajarathnam, K.; Natarajan, A. Biochem. Biophys. Res. Commun. 2010, 393, 207.
16. Grande, F.; Aiello, F.; Grazia, O. D.; Brizzi, A.; Garofalo, A.; Neamati, N. Bioorg. Med. Chem. 2007, 15, 288.
17. Gavara, L.; Saugues, E.; Alves, G.; Debiton, E.; Anizon, F.; Moreau, P. Eur. J. Med. Chem. 2010, 45, 5520.
18. Lopez, H.; Zhang, L.; George, N. M.; Liu, X.; Pang, X.; Evans, J. J.; Targy, N. M.; Luo, X. J. Biol. Chem. 2010, 285, 15016.
19. Zhang, L.; Lopez, H.; George, N. M.; Liu, X.; Pang, X.; Luo, X. Cell Death Differ., 2010, doi:10.1038/cdd.2010.152.