The novel and orally active thrombin receptor antagonist E5555 (Atopaxar) inhibits arterial thrombosis without affecting bleeding time in guinea pigs

European Journal of Pharmacology

Volumn 657, Issue 1-3, 2011, Pages 131-137

  Kogushi, Motoji ^a   Matsuoka, Toshiyuki ^a   Kawata, Tsutomu ^a   Kuramochi, Hiroko ^a   Kawaguchi, Shinki ^a   Murakami, Kimiyo ^a   Hiyoshi, Hironobu ^a   Suzuki, Shuichi ^a   Kawahara, Tetsuya ^a   Kajiwara, Akiharu ^a   Hishinuma, Ieharu ^a  

^a EISAI CO LTD   (Japan)

Author keywords

Aggregation; Bleeding time; E5555; Platelet; Protease activated receptor 1 antagonist; Thrombosis

Indexed keywords

ADENOSINE DIPHOSPHATE; ALTEPLASE; ATOPAXAR; COLLAGEN; E 5555; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN; THROMBIN RECEPTOR ACTIVATING PEPTIDE; THROMBIN RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY THROMBOSIS; ARTICLE; BLEEDING TIME; BLOOD CLOTTING TIME; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG EFFECT; GUINEA PIG; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MALE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; THROMBOCYTE AGGREGATION; THROMBOCYTE POOR PLASMA; THROMBOCYTE RICH PLASMA;

ADMINISTRATION, ORAL; ANIMALS; ARTERIES; BLOOD COAGULATION FACTORS; FIBRINOLYTIC AGENTS; GUINEA PIGS; HEMORRHAGE; HUMANS; IMINES; MALE; PLATELET AGGREGATION; PYRIDINES; RECEPTORS, THROMBIN; THROMBIN; THROMBOSIS; TIME FACTORS;

EID: 79952487685     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.01.058     Document Type: Article

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