Convection and retro-convection enhanced delivery: Some theoretical considerations related to drug targeting

Pharmaceutical Research

Volumn 28, Issue 3, 2011, Pages 472-479

  Motion, J P Michael ^a   Huynh, Grace H ^a   Szoka Jr , Francis C ^a   Siegel, Ronald A ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

blood brain barrier; convection enhanced delivery; finite element analysis; mathematical model; retroconvection enhanced delivery

Indexed keywords

AGAROSE;

BLOOD BRAIN BARRIER; BRAIN TUMOR; CONVECTION ENHANCED DELIVERY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG DISTRIBUTION; DRUG INFUSION; DRUG TARGETING; EXTRAVASCULAR SPACE; FLUID BALANCE; HUMAN; NONHUMAN; PRIORITY JOURNAL; RETROCONVECTION ENHANCED DELIVERY; REVIEW; THEORETICAL MODEL; TISSUE PRESSURE;

ANTINEOPLASTIC AGENTS; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CONVECTION; DRUG DELIVERY SYSTEMS; HYDRODYNAMICS; MODELS, BIOLOGICAL;

EID: 79952484479     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0296-2     Document Type: Review

References (31)

1. Tunggal JK, Cowan DS, Shaikh H, Tannock IF. Penetration of anticancer drugs through solid tissue: a factor that limits the effectiveness of chemotherapy for solid tumors. Clin Cancer Res. 1999;5(6):1583-6. (Pubitemid 29282967)
2. Groothuis DR, Benalcazar H, Allen CV, Wise RM, Dills C, Dobrescu C, et al. Comparison of cytosine arabinoside delivery to rat brain by intravenous, intrathecal, intraventricular and intraparenchymal routes of administration. Brain Res. 2000;856(1-2):281-90. (Pubitemid 30085537)
3. Huynh GH, Deen DF, Szoka Jr FC. Barriers to carrier mediated drug and gene delivery to brain tumors. J Control Release. 2006;110(2):236-59. (Pubitemid 41827478)
4. Groothuis DR, Vavra MW, Schlageter KE, Kang EW, Itskovich AC, Hertzler S, et al. Efflux of drugs and solutes from brain: the interactive roles of diffusional transcapillary transport, bulk flow and capillary transporters. J Cereb Blood Flow Metab. 2007;27 (1):43-56. (Pubitemid 46006583)
5. Chen MY, Lonser RR, Morrison PF, Governale LS, Oldfield EH. Variables affecting convection-enhanced delivery to the striatum: a systematic examination of rate of infusion, cannula size, infusate concentration, and tissue-cannula sealing time. J Neurosurg. 1999;90(2):315-20. (Pubitemid 29068134)
6. Lopez KA, Waziri AE, Canoll PD, Bruce JN. Convection-enhanced delivery in the treatment of malignant glioma. Neurol Res. 2006;28(5):542-8. (Pubitemid 44141325)
7. Hall WA, Rustamzadeh E, Asher AL. Convection-enhanced delivery in clinical trials. Neurosurg Focus. 2003;14(2):E2.
8. Raghavan R, Brady ML, Rodriguez-Ponce MI, Hartlep A, Pedain C, Sampson JH. Convection-enhanced delivery of therapeutics for brain disease, and its optimization. Neurosurg Focus. 2006;20(4):E12.
9. Voges J, Reszka R, Gossmann A, Dittmar C, Richter R, Garlip G, et al. Imaging-guided convection-enhanced delivery and gene therapy of glioblastoma. Ann Neurol. 2003;54(4):479-87. (Pubitemid 37176543)
10. Bobo RH, Laske DW, Akbasak A, Morrison PF, Dedrick RL, Oldfield EH. Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci USA. 1994;91(6):2076-80. (Pubitemid 24092045)
11. Krauze MT, Forsayeth J, Park JW, Bankiewicz KS. Real-time imaging and quantification of brain delivery of liposomes. Pharm Res. 2006;23(11):2493-504. (Pubitemid 44691597)
12. MacKay JA, Deen DF, Szoka Jr FC. Distribution in brain of liposomes after convection enhanced delivery; modulation by particle charge, particle diameter, and presence of steric coating. Brain Res. 2005;1035(2):139-53. (Pubitemid 40250186)
13. DiResta GR, Lee J, Healey JH, Levchenko A, Larson SM, Arbit E. "Artificial lymphatic system": a new approach to reduce interstitial hypertension and increase blood flow, pH and pO2 in solid tumors. Ann Biomed Eng. 2000;28(5):543-55.
14. Huynh GH, Ozawa T, Deen DF, Szoka Jr FC. Retro-convection enhanced delivery to increase blood to brain transfer of macromolecules. Brain Res. 2007;1128(1):181-90. (Pubitemid 46048631)
15. Baxter LT, Jain RK. Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection. Microvasc Res. 1989;37(1):77-104.
16. Kalyanasundaram S, Calhoun VD, Leong KW. A finite element model for predicting the distribution of drugs delivered intracranially to the brain. Am J Physiol. 1997;273 (5 Pt 2):R1810-21.
17. Basser PJ. Interstitial pressure, volume, and flow during infusion into brain tissue. Microvasc Res. 1992;44(2):143-65.
18. Levin VA, Patlak CS, Landahl HD. Heuristic modeling of drug delivery to malignant brain tumors. J Pharmacokinet Biopharm. 1980;8(3):257-96. (Pubitemid 10005954)
19. Morrison PF, Laske DW, Bobo H, Oldfield EH, Dedrick RL. High-flow microinfusion: tissue penetration and pharmacodynamics. Am J Physiol. 1994;266(1 Pt 2):R292-305.
20. Smith JH, Humphrey JA. Interstitial transport and transvascular fluid exchange during infusion into brain and tumor tissue. Microvasc Res. 2007;73(1):58-73. (Pubitemid 46072892)
21. Wang P, Olbricht WL. Retro-convection enhanced drug delivery: a computational study. Ann Biomed Eng. 2010;38(8):2512-9.
22. Verwey EJW, Overbeek JThG. Theory of the stability of lyophobic colloids. Mineola: Dover; 2000.
23. Gueron M, Weisbuch G. Polyelectrolyte theory.I.Counterion accumulation, site-binding and their insensitivity to polyelectrolyte shape in solutions containing finite salt concentrations. Biopolymers 1980;19:353-83.
24. Saito R, Bringas JR, McKnight TR, Wendland MF, Mamot C, Drummond DC, et al. Distribution of liposomes into brain and rat brain tumor models by convection-enhanced delivery monitored with magnetic resonance imaging. Cancer Res. 2004;64(7):2572-9. (Pubitemid 38523915)
25. Mamot C, Nguyen JB, Pourdehnad M, Hadaczek P, Saito R, Bringas JR, et al. Extensive distribution of liposomes in rodent brains and brain tumors following convection-enhanced delivery. J Neurooncol. 2004;68(1):1-9. (Pubitemid 39137344)
26. Krauze MT, Saito R, Noble C, Tamas M, Bringas J, Park JW, et al. Reflux-free cannula for convection-enhanced high-speed delivery of therapeutic agents. J Neurosurg. 2005;103 (5):923-9. (Pubitemid 43194589)
27. Gimenez F, Krauze MT, Valles F, Hadaczek P, Bringas J, Sharma N, et al. Image-guided convection-enhanced delivery of GDNF protein into monkey putamen. Neuroimage 2010. In press.
28. Hu X, Weinbaum S. A new view of starling's hypothesis at the microstructural level. Microvasc Res. 1999;58:281-304. (Pubitemid 29531876)
29. Saito R, Krauze MT, Bringas JR, Noble C, McKnight TR, Jackson P, et al. Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brain. Exp Neurol. 2005;196(2):381-9. (Pubitemid 41607827)
30. Levi MS, Brimble MA. A review of neuroprotective agents. Curr Med Chem. 2004;11(18):2383-97. (Pubitemid 39172356)
31. Neeves KB, Sawyer AJ, Foley CP, Saltzman WM, Olbricht WL. Dilation and degradation of the brain extracellular matrix enhances penetration of infused polymer nanoparticles. Brain Res. 2007;1180(14):121-32. (Pubitemid 350018737)