Serum transforming growth factor β1 during diabetes development in non-obese diabetic mice and humans

Clinical and Experimental Immunology

Volumn 162, Issue 3, 2010, Pages 407-414

  Olivieri, A ^a   De Angelis, S ^a   Dionisi, S ^a   D'Annunzio, G ^b   Locatelli, M ^a   Marinaro, M ^a   Bonato, V ^c   Amendola, A ^a   Songini, M ^d   Velluzzi, F ^e   Schirru, C ^d   Cotichini, R ^f   Stazi, M A ^f   Dotta, F ^c   Lorini, R ^b   Bottazzo, G F ^a   Boirivant, M ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d UNIVERSITY OF SIENA   (Italy)

^e BROTZU HOSPITAL   (Italy)

^f UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Insulitis; NOD mice; Prediabetes; TGF b1; Type 1 diabetes

Indexed keywords

GLUTAMATE DECARBOXYLASE ANTIBODY; INSULIN ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1; AUTOANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; DIABETES MELLITUS; DIABETIC PATIENT; DISEASE COURSE; DISEASE SEVERITY; DOUBLE ANTIBODY SANDWICH ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; ADOLESCENT; ANIMAL; BLOOD; C57BL MOUSE; CHILD; IMMUNOLOGY; INFLAMMATION; NONOBESE DIABETIC MOUSE; PANCREAS; PATHOLOGY; PATHOPHYSIOLOGY; PRESCHOOL CHILD;

ADOLESCENT; ANIMALS; AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; PANCREAS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 79952477064     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2010.04253.x     Document Type: Article

References (23)

1. Devendra D, Liu E, Eisenbarth GS. Type 1 diabetes: recent developments. BMJ 2004; 328:750-4.
2. Lindley S, Dayan CM, Bishop A et al. Defective suppressor function in CD4(+) CD25(+) T-cell from patients with type 1 diabetes. Diabetes 2005; 54:92-9.
3. Peng Y, Laouar Y, LiMO et al. TGF-β regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory cells responsible for protection against diabetes. Proc Natl Acad Sci USA 2004; 101:4572-7.
4. Marie JC, Letterio JJ, Gavin M et al. TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. J Exp Med 2005; 201:1061-7.
5. Anderson MS, Bluestone JA. The NOD mouse: a model of immune dysregulation. Annu Rev Immunol 2005; 23:447-85.
6. Lepault F, Gagnerault MC. Characterization of peripheral regulatory CD4 T cells that prevent diabetes onset in nonobese diabetic mice. J Immunol 2000; 164:240-7.
7. Szanya V, Ermann J, Taylor C et al. The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J Immunol 2002; 169:2461-5.
8. Pop SM, Wong CP, Culton DA, Clarke SH, Tisch R. Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med 2005; 201:1333-46.
9. Belghith M, Bluestone JA, Barriot S et al. TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med 2003; 9:1202-8.
10. Luo X, Yang H, Kim IS et al. Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice. Transplantation 2005; 79:1091-6.
11. Flaumenhaft R, Kojima S, Abe M et al. Activation of latent transforming growth factor β. Adv Pharmacol 1993; 24:51-76.
12. Wallik SC, Figari IS, Morris RE et al. Immunoregulatory role of transforming growth factor β (TGF-β) in development of killer cells: comparison of active and latent TGF-β1. J Exp Med 1990; 172:1777-84.
13. Chen W, Frank ME, Jin W et al. TGF-b released by apoptotic T cells contributes to an immunosuppressive milieu. Immunity 2001; 14:715-25.
14. Calcinaro F, Dionisi S, Marinaro M et al. Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse. Diabetologia 2005; 48:1565-75.
15. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2006; 29 (Suppl. 1):S43-8.
16. Casu A, Pascutto C, Bernardinelli L et al. Type 1 diabetes among Sardinian children is increasing: the Sardinian diabetes register for children aged 0-14 years (1989-1999). Diabetes Care 2004; 27:1623-9.
17. Pastore M, Bazzigaluppi E, Bonfanti R et al. Two-step islet autoantibody screening for risk assessment of type 1 diabetes in relatives. Diabetes Care 1998; 21:1445-50.
18. Locatelli M, Songini M, Bottazzo GF. IDDM Sardinia Project: a study model on the etiopathogenesis of insulin-dependent diabetes mellitus and other autoimmune pathologies. Ann Ist Super Sanità 1999; 35:253-63.
19. Vukkadapu SS, Belli JM, Ishii K et al. Dynamic interaction between T cell-mediated β-cell damage and β-cell repair in the run up to autoimmune diabetes of the NOD mouse. Physiol Genomics 2005; 21:201-11.
20. von Herrath M, Sanda S, Herold K. Type 1 diabetes as a relapsing-remitting disease?. Nat Rev Immunol 2007; 7:988-94.
21. Bonifacio E, Hummel M, Walter M et al. IDDM1 and multiple family history of type 1 diabetes combine to identify neonates at high risk for type 1 diabetes. Diabetes Care 2004; 11:2695-700.
22. Gorsuch AN, Spencer KM, Lister J et al. Evidence for a long pre-diabetic period in type I (insulin-dependent) diabetes mellitus. Lancet 1981; 2:1363-5.
23. Buzzetti R, Galgani A, Petrone A et al. Genetic prediction of type 1 diabetes in a population with low frequency of HLA risk genotypes and low incidence of the diseases (the DIABFIN study). Diabetes Metab Res Rev 2004; 20:137-43.