A shift towards a T cell cytokine deficiency along with an anti-inflammatory/regulatory microenvironment may enable the synthesis of anti-FVIII inhibitors in haemophilia a patients

Clinical and Experimental Immunology

Volumn 162, Issue 3, 2010, Pages 425-437

  Chaves, D G ^a,b,d   Velloso Rodrigues, C ^b,c   Oliveira, C A ^b   Teixeira Carvalho, A ^d   Santoro, M M ^a   Martins Filho, O A ^d  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b FUNDAÇÃO HEMOMINAS   (Brazil)

^c PONTIFICAL CATHOLIC UNIVERSITY OF MINAS GERAIS   (Brazil)

^d INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Antibody responses; Flow cytometry FACS; Haematology; Immune regulation; Intracellular cytokine staining

Indexed keywords

BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 8 ANTIBODY; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G4; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 5; RECOMBINANT PROTEIN; TUMOR NECROSIS FACTOR ALPHA; AUTOANTIBODY; CYTOKINE; F8 PROTEIN, HUMAN;

ADAPTIVE IMMUNITY; ADULT; ARTICLE; B LYMPHOCYTE; BLOOD DONOR; BLOOD SAMPLING; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HEMOPHILIA A; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; LEUKOCYTE; MAJOR CLINICAL STUDY; MONOCYTE; NEUTROPHIL; PRIORITY JOURNAL; T LYMPHOCYTE; ADOLESCENT; ANTIBODY PRODUCTION; BLOOD; CELL CULTURE; CHILD; FEMALE; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; LYMPHOCYTE ACTIVATION; MALE; METABOLISM; PATHOLOGY; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH1 TH2 BALANCE;

ADOLESCENT; ADULT; ANTIBODY FORMATION; AUTOANTIBODIES; CELLS, CULTURED; CHILD; CYTOKINES; FACTOR VIII; FEMALE; HEMOPHILIA A; HUMANS; IMMUNITY, INNATE; LYMPHOCYTE ACTIVATION; MALE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TH1-TH2 BALANCE;

EID: 79952467499     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2010.04258.x     Document Type: Article

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