Screening for lupus anticoagulant: Improving the performance of the lupus-sensitive PTT-LA

International Journal of Laboratory Hematology

Volumn 33, Issue 2, 2011, Pages 168-175

  Luginbuhl R ^b   Barizzi, G ^a   Sulzer, I ^a   Lammle B ^a   Alberio, L ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b Central Laboratory   (Switzerland)

Author keywords

Anticoagulant; APTT; Lupus; Ratio; Screening; Sensitivity

Indexed keywords

ANTIVITAMIN K; BLOOD CLOTTING FACTOR 8 INHIBITOR; BLOOD CLOTTING FACTOR 9 INHIBITOR; BLOOD CLOTTING INHIBITOR; HEPARIN; LUPUS ANTICOAGULANT; UNCLASSIFIED DRUG;

ARTICLE; BLOOD CLOTTING TIME; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; PILOT STUDY; PLASMA; PRIORITY JOURNAL; PROTHROMBIN TIME; SCREENING; SENSITIVITY AND SPECIFICITY;

HUMANS; LUPUS COAGULATION INHIBITOR; MASS SCREENING; PARTIAL THROMBOPLASTIN TIME; PILOT PROJECTS; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY;

EID: 79952464616     PISSN: 17515521     EISSN: 1751553X     Source Type: Journal    
DOI: 10.1111/j.1751-553X.2010.01262.x     Document Type: Article

References (21)

1. Adcock D.M. & Marlar R.A. (1992) Activated partial thromboplastin time reagent sensitivity to the presence of the lupus anticoagulant. Archives of Pathology and Laboratory Medicine 116, 837-840.
2. Arnout J., Meijer P. & Vermylen J. (1999) Lupus anticoagulant testing in Europe: an analysis of results from the first European Concerted Action on Thrombophilia (ECAT) survey using plasmas spiked with monoclonal antibodies against human beta2-glycoprotein I. Thrombosis and Haemostasis 81, 929-934.
3. Brancaccio V., Ames P.R., Glynn J., Iannaccone L. & Mackie I.J. (1997) A rapid screen for lupus anticoagulant with good discrimination from oral anticoagulants, congenital factor deficiency and heparin, is provided by comparing a sensitive and an insensitive APTT reagent. Blood Coagulation and Fibrinolysis 8, 155-160.
4. Brandt J.T., Barna L.K. & Triplett D.A. (1995) Laboratory identification of lupus anticoagulants: results of the second International Workshop for Identification of Lupus Anticoagulants. On behalf of the Subcommittee on Lupus Anticoagulants/Antiphospholipid Antibodies of the ISTH. Thrombosis and Haemostasis 74, 1597-1603.
5. Denis-Magdelaine A., Flahault A. & Verdy E. (1995) Sensitivity of sixteen APTT reagents for the presence of lupus anticoagulants. Haemostasis 25, 98-105.
6. Galli M., Finazzi G., Bevers E.M. & Barbui T. (1995) Kaolin clotting time and dilute Russell's viper venom time distinguish between prothrombin-dependent and beta 2-glycoprotein I-dependent antiphospholipid antibodies. Blood 86, 617-623.
7. Galli M., Finazzi G., Norbis F., Marziali S., Marchioli R. & Barbui T. (1999) The risk of thrombosis in patients with lupus anticoagulants is predicted by their specific coagulation profile. Thrombosis and Haemostasis 81, 695-700.
8. Galli M., Luciani D., Bertolini G. & Barbui T. (2003) Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood 101, 1827-1832.
9. Gardiner C., MacKie I.J., Malia R.G., Jones D.W., Winter M., Leeming D., Taberner D.A., Machin S.J. & Greaves M. (2000) The importance of locally derived reference ranges and standardized calculation of dilute Russell's viper venom time results in screening for lupus anticoagulant. British Journal Haematology 111, 1230-1235.
10. Kelsey P.R., Stevenson K.J. & Poller L. (1984) The diagnosis of lupus anticoagulants by the activated partial thromboplastin time - the central role of phosphatidyl serine. Thrombosis and Haemostasis 52, 172-175.
11. Lambert M., Ferrard-Sasson G., Dubucquoi S., Hachulla E., Prin L., Hatron P.Y., Goudemand J., Boffa M.C. & Caron C. (2009) Diluted Russell viper-venom time improves identification of antiphospholipid syndrome in a lupus anticoagulant-positive patient population. Thrombosis and Haemostasis 101, 577-581.
12. Lawrie A.S., Mackie I.J., Purdy G. & Machin S.J. (1999) The sensitivity and specificity of commercial reagents for the detection of lupus anticoagulant show marked differences in performance between photo-optical and mechanical coagulometers. Thrombosis and Haemostasis 81, 758-762.
13. Le Querrec A., Arnout J., Arnoux D., Borg J.Y., Caron C., Darnige L., Delahousse B., Reber G. & Sie P. (2001) Quantification of lupus anticoagulants in clinical samples using anti-beta2GP1 and anti-prothrombin monoclonal antibodies. Thrombosis and Haemostasis 86, 584-589.
14. Lewis S.M., Bain B.J. & Bates I. (2001) Dacie and Lewis Practical Haematology. Elsevier, Churchill Livingstone.
15. Miyakis S., Lockshin M.D., Atsumi T., Branch D.W., Brey R.L., Cervera R., Derksen R.H., DE Groot P.G., Koike T., Meroni P.L., Reber G., Shoenfeld Y., Tincani A., Vlachoyiannopoulos P.G. & Krilis S.A. (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). Journal of Thrombosis and Haemostasis 4, 295-306.
16. Pengo V., Biasiolo A., Rampazzo P. & Brocco T. (1999) dRVVT is more sensitive than KCT or TTI for detecting lupus anticoagulant activity of anti-beta2-glycoprotein I autoantibodies. Thrombosis and Haemostasis 81, 256-258.
17. Pengo V., Biasiolo A., Gresele P., Marongiu F., Erba N., Veschi F., Ghirarduzzi A., de Candia E., Montaruli B., Testa S., Barcellona D. & Tripodi A. (2007) Survey of lupus anticoagulant diagnosis by central evaluation of positive plasma samples. Journal of Thrombosis and Haemostasis 5, 925-930.
18. Pengo V., Tripodi A., Reber G., Rand J.H., Ortel T.L., Galli M. & De Groot P.G. (2009) Update of the guidelines for lupus anticoagulant detection. Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis. Journal of Thrombosis and Haemostasis 7, 1737-1740.
19. Rauch J., Tannenbaum M. & Janoff A.S. (1989) Distinguishing plasma lupus anticoagulants from anti-factor antibodies using hexagonal (II) phase phospholipids. Thrombosis and Haemostasis 62, 892-896.
20. Tripodi A., Biasiolo A., Chantarangkul V. & Pengo V. (2003) Lupus anticoagulant (LA) testing: performance of clinical laboratories assessed by a national survey using lyophilized affinity-purified immunoglobulin with LA activity. Clinical Chemistry 49, 1608-1614.
21. Urbanus R.T., Derksen R.H. & de Groot P.G. (2008) Current insight into diagnostics and pathophysiology of the antiphospolipid syndrome. Blood Reviews 22, 93-105.