The responsiveness of different APTT reagents to mild factor VIII, IX and XI deficiencies

International Journal of Laboratory Hematology

Volumn 33, Issue 2, 2011, Pages 154-158

  Bowyer, A ^a,b   Kitchen, S ^a   Makris, M ^a,b  

^a Sheffield Haemophilia and Thrombosis Centre   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

APTT; FIX; FVIII; FXI; Responsiveness

Indexed keywords

ACTIN FS; BLOOD CLOTTING FACTOR 11; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9; DAPTTIN; REAGENT; STA PTTA; SYNTHASIL; UNCLASSIFIED DRUG;

ARTICLE; BLOOD CLOTTING FACTOR 11 DEFICIENCY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE SEVERITY; HEMOPHILIA A; HEMOPHILIA B; HUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; SCREENING TEST; SENSITIVITY AND SPECIFICITY;

FACTOR IX; FACTOR VIII; FACTOR XI DEFICIENCY; FEMALE; HUMANS; MALE; PARTIAL THROMBOPLASTIN TIME; REAGENT KITS, DIAGNOSTIC; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 79952459837     PISSN: 17515521     EISSN: 1751553X     Source Type: Journal    
DOI: 10.1111/j.1751-553X.2010.01261.x     Document Type: Article

References (11)

1. Bethel M., Adcock D.M. & Ramanathan R. (2005). Intrinsic factor responsiveness of an APTT reagent is significantly influenced by the type of factor deficient plasma used. Journal of Thrombosis and Haemostasis 3, Supplement 1 abstract 1901.
2. Bolton-Maggs P.H.B., Young Wan-Yin B., McCraw A.H., Slack J. & Kernoff P.B.A. (1988) Inheritance and bleeding in factor XI deficiency. British Journal of Haematology 69, 521-528.
3. Bolton-Maggs P.H.B., Patterson D.A., Wensley R.T. & Tuddenham E.G.D. (1995) Definition of the bleeding tendency in factor XI kindreds-a clinical and laboratory study. Thrombosis Haemostasis 73, 194-202.
4. Clinical and Laboratory Standards Institute (CLSI) (2008) One-stage prothrombin (PT) test and activated partial thromboplastin time (APTT) test. Approved guideline H47-A2. 28 (20).
5. Lawrie A.S., Kitchen S., Purdy G., Mackie I.J., Preston F.E. & Machin S.J. (1998) Assessment of Actin FS and Actin FSL sensitivity to specific clotting factor deficiencies. Clinical and Laboratory Haematology 20, 179-186.
6. Mikaelsson M., Oswaldsson U. & Sandberg H. (1998) Influence of phospholipids on the assessment of factor VIII activity. Haemophilia 4, 646-650.
7. Plug I., Mauser-Bunschoten E.P., Brocker-Vriends A.H.J.T., van Amstel H.K.P., van der Bom J.G., van Dieman-Homan J.E.M., Willemse J. & Rosendaal F.R. (2006) Bleeding in carriers of haemophilia. Blood 108, 52-56.
8. Pouplard C., Trossaert M., Le Querrec A., Delahousse B., Giraudeau B. & Gruel Y. (2009) Influence of source of phospholipids for APTT-based factor IX assays and potential consequences for the diagnosis of mild haemophilia B. Haemophilia 15, 365-368.
9. Stevenson K.J., Easton A.C., Curry A., Thomson J.M. & Poller L. (1986) The reliability of activated partial thromboplastin time methods and the relationship to lipid composition and ultrastructure. Thrombosis Haemostasis 55, 250-258.
10. Teruya J., Oropeza M. & Ramsey G. (2001) A normal APTT does not guarantee adequate coagulation factor levels. Anaesthesiology 94, 542.
11. Turi D.C. & Peerschke E.I. (1986) Sensitivity of three activated partial thromboplastin time reagents to coagulation factor deficiencies. American Journal of Clinical Pathology 85, 43-49.