Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase i inhibitors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 6, 2011, Pages 1924-1929

  Khadka, Daulat Bikram ^a   Le, Quynh Manh ^a   Yang, Su Hui ^a   Van, Hue Thi My ^a   Le, Thanh Nguyen ^a   Cho, Suk Hee ^a   Kwon, Youngjoo ^b   Lee, Kyung Tae ^c   Lee, Eung Seok ^d   Cho, Won Jea ^a  

^a Chonnam National University   (South Korea)

^b Ewha Womans University   (South Korea)

^c Kyung Hee University   (South Korea)

^d Yeungnam University   (South Korea)

Author keywords

Cytotoxicity; Docking study; Indeno 1,2 c isoquinolines; Topoisomerase I

Indexed keywords

11 HEXYL 5 (4 METHYLPIPERAZINE 1 YL) 11H INDENO[1,2 C]ISOQUINOLIN; 11 METHYL 5 (4 METHYLPIPERAZINE 1 YL) 11H INDENO[1,2 C]ISOQUINOLIN; 145 (4 METHYLPIPERAZINE 1 YL) 11H INDENO[1,2 C]ISOQUINOLIN; 5 (4 ETHYLPIPERAZIN 1 YL) 11H INDENO[1,2 C]ISOQUINOLIN; 5 (4 ETHYLPIPERAZIN 1 YL) 11H INDENO[1,2 C]ISOQUINOLIN 11 OL; 5 (4 ETHYLPIPERAZIN 1 YL)INDENO[1,2 C]ISOQUINOLIN 11 ONE; 5 (4 METHYL [1,4DIAZEPAM] 1 YL) 11H INDENO[1,2 C]ISOQUINOLIN; 5 (4 METHYL[1,4]DIAZEPAM1 YL)INDENOL[1,2 C]ISOQUINOLIN 11 ONE; 5 (4 METHYLPIPERAZIN 1 YL) 11H INDENO[1,2 C]ISOQUINOLIN; 5 (4 METHYLPIPERAZIN 1 YL)INDENO[1,2C]ISOQUINOLIN 11 ONE; 5 AMINO SUBSTITUTED INDENO[1,2 C]ISOQUINOLINE DERIVATIVE; 5 BUTYLAMINOINDENOL[1,2 C]ISOQUINOLIN ONE; 5 MORPHOLINO 4 YL 11H INDENO[1,2 C]ISOQUINOLIN; 5 MORPHOLINO 4 YL 11H INDENO[1,2 C]ISOQUINOLIN 11 OL; 5 MORPHOLINO 4 YL INDENO[1,2 C]ISOQUINOLIN 11 ONE; 5 PIPERAZIN 1 YLINDENO[1,2 C]ISOQUINOLIN ONE; ACETIC ACID 5 MORPHOLINO 4 YL 11H INDENOL[1,2 C]ISOQUINOLIN 11 YL ESTER; DNA TOPOISOMERASE INHIBITOR; N BUTYL (11H INDENO[1,2 C]ISOQUINOLIN 5 YL)AMINE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CYTOTOXICITY TEST; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; MOLECULAR DOCKING; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; DNA TOPOISOMERASES, TYPE I; DRUG DESIGN; HUMANS; ISOQUINOLINES; PIPERAZINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS;

RUMEX;

EID: 79952442830     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.01.064     Document Type: Article

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