Efficient tetanus toxoid immunization on vitamin D supplementation

European Journal of Clinical Nutrition

Volumn 65, Issue 3, 2011, Pages 329-334

  Heine, G ^a,b   Drozdenko, G ^a   Lahl, A ^a   Unterwalder, N ^a   Mei, H ^a,b   Volk, H D ^a   Dorner T ^a,b   Radbruch, A ^b   Worm, M ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

Author keywords

humoral recall response; immunization; supplementation; tetanus toxoid; vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; COLECALCIFEROL; DIPHTHERIA TETANUS TOXOID; GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; MERIEUX; PLACEBO; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; CELL SPECIFICITY; COMMON COLD; CONTROLLED STUDY; CYTOKINE RELEASE; DIPHTHERIA; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG POTENTIATION; DRUG TOLERABILITY; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOGLOBULIN BLOOD LEVEL; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; T LYMPHOCYTE; TETANUS; TREATMENT DURATION; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION;

ERGOCALCIFEROLS; HUMANS; IMMUNIZATION, SECONDARY; IMMUNOGLOBULIN G; LUPUS ERYTHEMATOSUS, CUTANEOUS; SEASONS; T-LYMPHOCYTES; TETANUS TOXOID; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 79952439721     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2010.276     Document Type: Article

References (22)

1. Adams JS, Hewison M (2008). Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab 4, 80-90. (Pubitemid 351156900)
2. Adorini L, Penna G (2008). Control of autoimmune diseases by the vitamin D endocrine system. Nat Clin Pract Rheumatol 4, 404-412.
3. Daniel C, Schlauch T, Zugel U, Steinmeyer A, Radeke HH, Steinhilber D et al. (2005). 22-ene-25-oxa-vitamin D: a new vitamin D analogue with profound immunosuppressive capacities. Eur J Clin Invest 35, 343-349. (Pubitemid 40691282)
4. De Rosa SC, Lu FX, Yu J, Perfetto SP, Falloon J, Moser S et al. (2004). Vaccination in humans generates broad T cell cytokine responses. J Immunol 173, 5372-5380. (Pubitemid 39392120)
5. Enioutina EY, Bareyan D, Daynes RA (2008). TLR ligands that stimulate the metabolism of vitamin D3 in activated murine dendritic cells can function as effective mucosal adjuvants to subcutaneously administered vaccines. Vaccine 26, 601-613.
6. Enioutina EY, Visic D, McGee ZA, Daynes RA (1999). The induction of systemic and mucosal immune responses following the subcutaneous immunization of mature adult mice: characteri-zation of the antibodies in mucosal secretions of animals immunized with antigen formulations containing a vitamin D3 adjuvant. Vaccine 17, 3050-3064. (Pubitemid 29366985)
7. Frentsch M, Arbach O, Kirchhoff D, Moewes B, Worm M, Rothe M et al. (2005). Direct access to CD4 + T cells specific for defined antigens according to CD154 expression. Nat Med 11, 1118-1124. (Pubitemid 41486836)
8. Frolich D, Giesecke C, Mei HE, Reiter K, Daridon C, Lipsky PE et al. (2010). Secondary immunization generates clonally related anti-gen-specific plasma cells and memory B cells. J Immunol 185, 3103-3110.
9. Hayes CE, Nashold FE, Spach KM, Pedersen LB (2003). The immuno-logical functions of the vitamin D endocrine system. Cell Mol Biol (Noisy-le-grand) 49, 277-300.
10. Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ (2003). Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 77, 204-210. (Pubitemid 36015393)
11. Heine G, Anton K, Henz BM, Worm M (2002). 1alpha,25-dihydroxy-vitamin D3 inhibits anti-CD40 plus IL-4-mediated IgE production in vitro. Eur J Immunol 32, 3395-3404. (Pubitemid 36024377)
12. Heine G, Niesner U, Chang HD, Steinmeyer A, Zugel U, Zuberbier T et al. (2008). 1,25-dihydroxyvitamin D(3) promotes IL-10 produc-tion in human B cells. Eur J Immunol 38, 2210-2218.
13. Hintzpeter B, Mensink GB, Thierfelder W, Muller MJ, Scheidt-Nave C (2008). Vitamin D status and health correlates among German adults. Eur J Clin Nutr 62, 1079-1089.
14. Holick MF (2007). Vitamin D deficiency. NEngl J Med 357, 266-281.
15. Ivanov AP, Dragunsky EM, Chumakov KM (2006). 1,25-dihydroxy-vitamin D3 enhances systemic and mucosal immune responses to inactivated poliovirus vaccine in mice. J Infect Dis 193, 598-600. (Pubitemid 43202752)
16. Mei HE, Yoshida T, Sime W, Hiepe F, Thiele K, Manz RA et al. (2008). Blood-borne human plasma cells in steady-state are derived from mucosal immune responses. Blood 113, 2461-2469.
17. Odendahl M, Mei H, Hoyer BF, Jacobi AM, Hansen A, Muehlinghaus G et al. (2005). Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response. Blood 105, 1614-1621. (Pubitemid 40223682)
18. Schleithoff SS, Zittermann A, Tenderich G, Berthold HK, Stehle P, Koerfer R (2006). Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 83, 754-759. (Pubitemid 44713136)
19. Van der Stede Y, Cox E, Van den broeck W, Goddeeris BM (2001). Enhanced induction of the IgA response in pigs by calcitriol after intramuscular immunization. Vaccine 19, 1870-1878. (Pubitemid 32178334)
20. Vieth R (1999). Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 69, 842-856. (Pubitemid 29205056)
21. Vieth R (2007). Vitamin D toxicity, policy, and science. J Bone Miner Res 22 (Suppl 2), V64-V68. (Pubitemid 351304652)
22. Zittermann A, Dembinski J, Stehle P (2004). Lowvitamin D status is associated with low cord blood levels of the immunosuppressive cytokine interleukin-10. Pediatr Allergy Immunol 15, 242-246. (Pubitemid 38937568)