Iatrogenic osteoporosis, bilateral hip osteonecrosis, and secondary adrenal suppression in an HIV-infected man receiving inhaled corticosteroids and ritonavir-boosted highly active antiretroviral therapy

Endocrine Practice

Volumn 17, Issue 1, 2011, Pages 74-78

  Kaviani, Nargess ^a   Bukberg, Phillip ^b   Manessis, Anastasios ^c   Yen, Vincent ^b   Young, Iven ^c,d  

^a North Shore Long Island Jewish Health System ^*  (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^d ST VINCENT S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAZANAVIR; FLUTICASONE PROPIONATE PLUS SALMETEROL; LAMIVUDINE PLUS ZIDOVUDINE; RITONAVIR; SALBUTAMOL; TENOFOVIR; TESTOSTERONE;

ADRENAL INSUFFICIENCY; ADRENAL SUPPRESSION; ADULT; ARTICLE; BONE DENSITOMETRY; BRONCHIECTASIS; CASE REPORT; CLINICAL ASSESSMENT; CORTICOSTEROID THERAPY; FEMUR HEAD NECROSIS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIP RADIOGRAPHY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPOGONADISM; LABORATORY DIAGNOSIS; MALE; OSTEOPOROSIS; TOTAL HIP PROSTHESIS; VERTEBRA FRACTURE;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; ADRENAL INSUFFICIENCY; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; OSTEONECROSIS; OSTEOPOROSIS; RITONAVIR;

EID: 79952420803     PISSN: 1530891X     EISSN: None     Source Type: Journal    
DOI: 10.4158/EP09288.CR     Document Type: Article

References (16)

1. Medina F, Pérez-Saleme L, Moreno J. Rheumatic manifestation of human immunodeficiency virus infection. Infect Dis Clin N Am. 2006;20:891-912. (Pubitemid 44752021)
2. Blangy H, Loeuille D, Chary-Valckenaere I, et al. Osteonecrosis of the femoral head in HIV-1 patients: Four additional cases. AIDS. 2000;14:2214-2215.
3. Meyer D, Behrens G, Schmidt RE, Stoll M. Osteonecrosis of the femoral head in patients receiving HIV protease inhibitors. AIDS. 1999;13:1147-1148. (Pubitemid 29361412)
4. Soldatos G, Sztal-Mazer S, Woolley I, Stockigt J. Exogenous glucocorticoid excess as a result of ritonavir-fluticasone interaction. Intern Med J. 2005;35:67-68. (Pubitemid 40254773)
5. Samara K, Pett S, Gowers S, McMurchie M, Cooper DA. Iatrogenic Cushing's syndrome with osteoporosis and secondary adrenal failure in human immunodeficiency virus-infected patients receiving inhaled corticosteroids and ritonavir-boosted protease inhibitors: Six cases. J Clin Endocrinol Metab. 2005;90:4394-4398. (Pubitemid 41058226)
6. Lipworth BJ, Jackson CM. Safety of inhaled and intranasal corticosteroids: Lessons for the new millennium. Drug Saf. 2000;11-33. (Pubitemid 30455915)
7. Cranney A, Adachi JD. Corticosteroid-induced osteoporosis: A guide to optimum management. Treat Endocrinol. 2002;1:271-279. (Pubitemid 37047234)
8. Tebas P, Powderly WG, Claxon S, et al. Accelerated bone mineral loss in HIV-infected patients receiving potent antiretroviral therapy. AIDS. 2000;10:F63-F67. (Pubitemid 30182458)
9. Medina F, Perez L, Sartorius C, et al. Osteoporosis in human immunodeficiency infected patients. Arthritis Rheum. 2000;43:S203.
10. Dybul M, Fauci AS, Bartlett JG, Kaplan JE, Pau AK; Panel on Clinical Practices for Treatment of HIV. Guidelines for using antiretroviral agents among HIV-infected adults and adolescents. Ann Intern Med. 2002;137(5 Pt 2):381-433. (Pubitemid 34982041)
11. Zeldin RK, Petruschke RA. Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIV-infected patients. J Antimicrob Chemother. 2004;53:4-9. (Pubitemid 38072176)
12. Siddiqui NA, Shetty KR, Duthie EH Jr. Osteoporosis in older men: Discovering when and how to treat it. Geriatrics. 1999;54:20.
13. Lipworth BJ. Systemic Adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysis. Arch Intern Med. 1999;159:941-955. (Pubitemid 29222495)
14. Rademaker J, Dobro JS, Solomon G. Osteonecrosis and human immunodeficiency virus infection. J Rheumatol. 1997;24:601-604. (Pubitemid 27153433)
15. Kelly HW. Non-corticosteroid therapy for the long-term control of asthma. Expert Opin Pharmacother. 2007;8:2077-2087. (Pubitemid 47505586)
16. Gronholz MJ. Prevention, diagnosis, and management of osteoporosis-related fracture: A multifactoral osteopathic approach. J Am Osteopath Assoc. 2008;108:575-585.