The interaction among donor characteristics, severity of liver disease, and the cost of liver transplantation

Liver Transplantation

Volumn 17, Issue 3, 2011, Pages 233-242

  Salvalaggio, Paolo R ^a   Dzebisashvili, Nino ^b   MacLeod, Kara E ^a,c   Lentine, Krista L ^b   Gheorghian, Adrian ^b   Schnitzler, Mark A ^b   Hohmann, Samuel ^d   Segev, Dorry L ^e   Gentry, Sommer E ^f   Axelrod, David A ^g  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d University HealthSystem Consortium   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNITED STATES NAVAL ACADEMY   (United States)

^g DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANOXIA; ARTICLE; BRAIN DEATH; CEREBROVASCULAR ACCIDENT; COLD ISCHEMIA; CONTROLLED STUDY; DISEASE REGISTRY; DISEASE SEVERITY; FEMALE; HEALTH CARE COST; HEART DEATH; HEPATITIS B; HEPATITIS C; HOSPITAL READMISSION; HUMAN; LIVER CELL CARCINOMA; LIVER DISEASE; LIVER GRAFT; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; ORGAN DONOR; PERIOPERATIVE PERIOD; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; QUALITY CONTROL; RACE DIFFERENCE; RETRANSPLANTATION; RETROSPECTIVE STUDY;

ADOLESCENT; ADULT; AGED; DONOR SELECTION; FEMALE; HOSPITAL COSTS; HUMANS; KAPLAN-MEIER ESTIMATE; LINEAR MODELS; LIVER DISEASES; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; PATIENT READMISSION; REGISTRIES; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TISSUE AND ORGAN PROCUREMENT; TISSUE DONORS; TREATMENT OUTCOME; UNITED STATES; YOUNG ADULT;

EID: 79952403200     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.22230     Document Type: Article

References (27)

1. Evans RW, Manninen DL, Dong FB., An economic analysis of liver transplantation: costs, insurance coverage, and reimbursement. Gastroenterol Clin North Am 1993; 22: 451-473. (Pubitemid 23194299)
2. Bonsel GJ, Klompmaker IJ, Essink-Bot ML, Habbema JD, Slooff MJ., Cost-effectiveness analysis of the Dutch liver transplantation programme. Transplant Proc 1990; 22: 1481-1484. (Pubitemid 20284410)
3. Taylor MC, Greig PD, Detsky AS, McLeod RS, Abdoh A, Krahn MD., Factors associated with the high cost of liver transplantation in adults. Can J Surg 2002; 45: 425-434. (Pubitemid 36133657)
4. Showstack J, Katz PP, Lake JR, Brown RS Jr, Dudley RA, Belle S, et al. Resource utilization in liver transplantation: effects of patient characteristics and clinical practice. JAMA 1999; 281: 1381-1386. (Pubitemid 29190215)
5. Freeman RB Jr., Model for End-Stage Liver Disease (MELD) for liver allocation: a 5-year score card. HEPATOLOGY 2008; 47: 1052-1057. (Pubitemid 351449696)
6. Merion RM, Schaubel DE, Dykstra DM, Freeman RB, Port FK, Wolfe RA., The survival benefit of liver transplantation. Am J Transplant 2005; 5: 307-313. (Pubitemid 40179517)
7. Axelrod DA, Koffron AJ, Baker T, Al-Saden P, Dixler I, McNatt G, et al. The economic impact of MELD on liver transplant centers. Am J Transplant 2005; 5: 2297-2301. (Pubitemid 41648479)
8. Washburn WK, Pollock BH, Nichols L, Speeg KV, Halff G., Impact of recipient MELD score on resource utilization. Am J Transplant 2006; 6: 2449-2454. (Pubitemid 44359433)
9. Feng S, Goodrich NP, Bragg-Gresham JL, Dyskstra DM, Punch JD, DebRoy MA, et al. Characteristics associated with liver graft failure: The concept of a Donor Risk Index. Am J Transplant 2006; 6: 783-790. (Pubitemid 43345017)
10. Schaubel DE, Sima CS, Goodrich NP, Feng S, Merion RM., The survival benefit of deceased donor liver transplantation as a function of candidate disease severity and donor quality. Am J Transplant 2008; 8: 419-425. (Pubitemid 351175358)
11. Axelrod DA, Schnitzler M, Salvalaggio PR, Swindle J, Abecassis MM., The economic impact of the utilization of liver allografts with high donor risk index. Am J Transplant 2007; 7: 990-997. (Pubitemid 46481202)
12. Washburn WK, Meo NA, Halff GA, Roberts JP, Feng S., Factors influencing liver transplant length of stay at two large-volume transplant centers. Liver Transpl 2009; 15: 1570-1578.
13. de Vera ME, Lopez-Solis R, Dvorchik I, Campos S, Morris W, Demetris AJ, et al. Liver transplantation using donation after cardiac death donors: long-term follow-up from a single center. Am J Transplant 2009; 9: 773-781.
14. Abecassis M., Making dollars and sense out of liver transplantation. Liver Transpl 2009; 15: 1159-1161.
15. Wiesner R, Edwards E, Freeman R, Harper A, Kim R, Kamath P, et al. Model for end-stage liver disease (MELD) and allocation of donor livers. Gastroenterology 2003; 124: 91-96. (Pubitemid 36055342)
16. Washburn WK, Pollock BH, Nichols L, Speeg KV, Halff G., Impact of recipient MELD score on resource utilization. Am J Transplant 2006; 6: 2449-2454. (Pubitemid 44359433)
17. Gold MR, Siegel JE, Russell LB, Weinstein MC, eds. Cost-Effectiveness in Health and Medicine. New York: Oxford University Press; 1996.
18. Buchanan P, Dzebisashvili N, Lentine KL, Axelrod DA, Schnitzler MA, Salvalaggio PR., Liver transplantation cost in the model for end-stage liver disease era: looking beyond the transplant admission. Liver Transpl 2009; 15: 1270-1277.
19. Moylan CA, Brady CW, Johnson JL, Smith AD, Tuttle-Newhall JE, Muir AJ., Disparities in liver transplantation before and after introduction of the MELD score. JAMA 2008; 300: 2371-2378.
20. Jay CL, Lyuksemburg V, Kang R, Preczewski L, Stroupe K, Holl JL, et al. The increased costs of donation after cardiac death liver transplantation: caveat emptor. Ann Surg 2010; 251: 743-748.
21. Pomfret EA, Fryer JP, Sima CS, Lake JR, Merion RM., Liver and intestine transplantation in the United States, 1996-2005. Am J Transplant 2007; 7 (5 Pt 2): 1376-1389. (Pubitemid 46606941)
22. Merion RM, Goodrich NP, Feng S., How can we define expanded criteria for liver donors? J Hepatol 2006; 45: 484-488.
23. Ammori JB, Pelletier SJ, Lynch R, Cohn J, Ads Y, Campbell DA, Englesbe MJ,. Incremental costs of post-liver transplantation complications J Am Coll Surg 2008; 206: 89-95. (Pubitemid 350267243)
24. Englesbe MJ, Dimick J, Mathur A, Ads Y, Welling TH, Pelletier SJ, et al. Who pays for biliary complications following liver transplant? A business case for quality improvement. Am J Transplant 2006; 6: 2978-2982.
25. Abecassis MM., Financial outcomes in transplantation - a provider's perspective. Am J Transplant 2006; 6: 1257-1263. (Pubitemid 44030307)
26. Axelrod DA, Swindle J, Salvalaggio PR, Buchanan P, Schnitzler M., Reducing the cost of marginal organ utilization: is there a national learning curve? [Abstract] Am J Transplant 2007; 7 (Suppl): 283-284.
27. Selck FW, Grossman EB, Ratner LE, Renz JF., Utilization, outcomes, and retransplantation of liver allografts from donation after cardiac death: implications for further expansion of the deceased-donor pool. Ann Surg 2008; 248: 599-607.