Targeting RAF: Trials and tribulations

Nature Medicine

Volumn 17, Issue 3, 2011, Pages 286-288

  Downward, Julian ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

A RAF KINASE; B RAF KINASE; B RAF KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PLX 4032; RAF PROTEIN; SOMATOMEDIN C RECEPTOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER RESISTANCE; DRUG EFFICACY; DRUG SELECTIVITY; DRUG TARGETING; ENZYME ACTIVATION; GENE MUTATION; HUMAN; MELANOMA; MOLECULARLY TARGETED THERAPY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

DRUG RESISTANCE, NEOPLASM; HUMANS; MUTATION; NEOPLASMS; PROTEIN KINASE INHIBITORS;

EID: 79952389822     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm0311-286     Document Type: Article

References (9)

1. Flaherty, K.T. et al. N. Engl. J. Med. 363, 809-819 (2010).
2. Johannessen, C.M. et al. Nature 468, 968-972 (2010).
3. Nazarian, R. et al. Nature 468, 973-977 (2010).
4. Villanueva, J. et al. Cancer Cell 18, 683-695 (2010).
5. Garnett, M.J., Rana, S., Paterson, H., Barford, D. & Marais, R. Mol. Cell 20, 963-969 (2005).
6. Hatzivassiliou, G. et al. Nature 464, 431-435 (2010).
7. Heidorn, S.J. et al. Cell 140, 209-221 (2010).
8. Poulikakos, P.I., Zhang, C., Bollag, G., Shokat, K.M. & Rosen, N. Nature 464, 427-430 (2010).
9. Robert, C., Arnault, J.P. & Mateus, C. Curr. Opin. Oncol. published online, doi:10.1097/ CCO.0b013e3283436e8c (29 December 2010).