Increased circulating Th17 frequencies and serum IL-22 levels in patients with acute generalized exanthematous pustulosis

Journal of the European Academy of Dermatology and Venereology

Volumn 25, Issue 4, 2011, Pages 485-488

  Kabashima, R ^a   Sugita, K ^a   Sawada, Y ^a   Hino, R ^a   Nakamura, M ^a   Tokura, Y ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

acute generalized exanthematous pustulosis; drug eruption; IL 17; IL 22; Th17

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 22; INTERLEUKIN 4; INTERLEUKIN 8;

ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS; ADULT; AGED; ARTICLE; CASE REPORT; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; MALE; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TH17 CELL;

ADULT; AGED; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXANTHEMA; FEMALE; HUMANS; INTERLEUKINS; MALE; MIDDLE AGED; TH17 CELLS;

EID: 79952372813     PISSN: 09269959     EISSN: 14683083     Source Type: Journal    
DOI: 10.1111/j.1468-3083.2010.03771.x     Document Type: Article

References (12)

1. Sidoroff A, Dunant A, Viboud C, et al. Risk factors for acute generalized exanthematous pustulosis (AGEP)-results of a multinational case-control study (EuroSCAR). Br J Dermatol 2007; 157: 989-996. (Pubitemid 47583506)
2. Anliker MD, Wuthrich B,. Acute generalized exanthematous pustulosis due to sulfamethoxazol with positive lymphocyte transformation test (LTT). J Investig Allergol Clin Immunol 2003; 13: 66-68. (Pubitemid 36781526)
3. Schaerli P, Britschgi M, Keller M, et al. Characterization of human T cells that regulate neutrophilic skin inflammation. J Immunol 2004; 173: 2151-2158. (Pubitemid 38971654)
4. Girardi M, Duncan KO, Tigelaar RE, et al. Cross-comparison of patch test and lymphocyte proliferation responses in patients with a history of acute generalized exanthematous pustulosis. Am J Dermatopathol 2005; 27: 343-346. (Pubitemid 41232490)
5. Britschgi M, Steiner UC, Schmid S, et al. T-cell involvement in drug-induced acute generalized exanthematous pustulosis. J Clin Invest 2001; 107: 1433-1441. (Pubitemid 32522037)
6. Nishio D, Izu K, Kabashima K, Tokura Y,. T cell populations propagating in the peripheral blood of patients with drug eruptions. J Dermatol Sci 2007; 48: 25-33. (Pubitemid 47284803)
7. Zaba LC, Fuentes-Duculan J, Eungdamrong NJ, et al. Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells. J Invest Dermatol 2009; 129: 79-88.
8. Zheng Y, Danilenko DM, Valdez P, et al. Interleukin-22, a Th17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 2007; 445: 648-651. (Pubitemid 46232884)
9. Koga C, Kabashima K, Shiraishi N, et al. Possible pathogenic role of Th17 cells for atopic dermatitis. J Invest Dermatol 2008; 128: 2625-2630.
10. Nakamizo S, Kobayashi S, Usui T, et al. Clopidogrel-induced acute generalized exanthematous pustulosis with elevated Th17 cytokines levels as determined by a drug lymphocyte stimulation test. Br J Dermatol 2010; 162: 1402-1403.
11. Roujeau JC, Bioulac-Sage P, Bourseau C, et al. Acute generalized exanthematous pustulosis. Analysis of 63 cases. Arch Dermatol 1991; 127: 1333-1338.
12. Sawada Y, Sugita K, Fukamachi S, et al. Doripenem-induced intertriginous drug eruption as a mild form of AGEP. J Eur Acad Dermatol Venereol 2009; 23: 974-976.