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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 6, 2011, Pages 1827-1831

Design and synthesis of novel CCR2 antagonists: Investigation of non-aryl/heteroaryl binding motifs

(12) Trujillo, John I a Huang, Wei a Hughes, Robert O a Joseph Rogier, D a Turner, Steven R a Devraj, Rajesh a Morton, Philip A a Xue, Chu Biao b Chao, Ganfeng b Covington, Maryanne B b Newton, Robert C b Metcalf, Brian b

a PFIZER INC (United States)

b Experimental Station (United States)

Author keywords

CCR2 antagonists; Central penetrance; Diazobicyclo 2.2.1 heptane; Dofetilide; Fluoropyran; hERG; Inflammatory diseases; MCP 1; Neuropathic pain

Indexed keywords

CHEMOKINE RECEPTOR CCR2 ANTAGONIST; DOFETILIDE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRAN DERIVATIVE;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; OUTCOME ASSESSMENT; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

BINDING SITES; DRUG DESIGN; MODELS, MOLECULAR; RECEPTORS, CCR2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79952361176 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2011.01.052 Document Type: Article

Times cited : (7)

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