Modelling of intercellular induction of apoptosis in oncogenic transformed cells and radiation effects on the phenomenon

Radiation Protection Dosimetry

Volumn 143, Issue 2-4, 2011, Pages 549-553

  Kundrat P ^a   Friedland, W ^a   Jacob, P ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; APOPTOSIS; ARTICLE; BIOLOGICAL MODEL; CELL TRANSFORMATION; COMPUTER SIMULATION; HUMAN; PATHOPHYSIOLOGY; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INDUCED NEOPLASM;

ANIMALS; APOPTOSIS; CELL TRANSFORMATION, NEOPLASTIC; COMPUTER SIMULATION; HUMANS; MODELS, BIOLOGICAL; NEOPLASMS, RADIATION-INDUCED; RADIATION DOSAGE;

EID: 79952346148     PISSN: 01448420     EISSN: 17423406     Source Type: Journal    
DOI: 10.1093/rpd/ncq521     Document Type: Article

References (7)

1. Bauer, G. Low dose radiation and intercellular induction of apoptosis: potential implications for the control of oncogenesis. Int. J. Radiat. Biol. 83, 873-888 (2007).
2. Bechtel, W. and Bauer, G. Catalase protects tumor cells from apoptosis induction by intercellular ROS signaling. Anticancer Res. 29, 4541-4557 (2009).
3. 2. and NO: how far can either radical, or any specific reaction product, transmit a message under in vivo conditions? Chem. Biol. Interact. 90, 35-45 (1994).
4. Portess, D. I., Bauer, G., Hill, M. A. and O'Neill, P. Low-dose irradiation of nontransformed cells stimulates the selective removal of precancerous cells via intercellular induction of apoptosis. Cancer Res. 67, 1246-1253 (2007).
5. Ivanovas, B., Zerweck, A. and Bauer, G. Selective and non-selective apoptosis induction in transformed and non-transformed fibroblasts by exogenous reactive oxygen and nitrogen species. Anticancer Res. 22, 841-856 (2002).
6. Heigold, S., Sers, C., Bechtel, W., Ivanovas, B., Schäfer, R. and Bauer, G. Nitric oxide mediates apoptosis induction selectively in transformed fibroblasts compared to nontransformed fibroblasts. Carcinogenesis 23, 929-941 (2002).
7. Herdener, M., Heigold, S., Saran, M. and Bauer, G. Target cell-derived superoxide anions cause efficiency and selectivity of intercellular induction of apoptosis. Free Radic. Biol. Med. 29, 1260-1271 (2000).