Bladder contractility is mediated by different K+ channels in the urothelium and detrusor smooth muscle

Journal of Pharmacological Sciences

Volumn 115, Issue 2, 2011, Pages 127-134

  Santoso, Aneira Gracia Hidayat ^a   Liang, Willmann ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

Contractility; Detrusor smooth muscle; Urothelium

Indexed keywords

4 AMINOPYRIDINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM); APAMIN; CARBACHOL; CHARYBDOTOXIN; GLIBENCLAMIDE; IBERIOTOXIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; POTASSIUM CHANNEL; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; BLADDER CONTRACTION; CONTROLLED STUDY; DETRUSOR MUSCLE; DRUG EFFICACY; DRUG POTENCY; DRUG RESPONSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; SMOOTH MUSCLE FIBER; UROTHELIUM;

EID: 79952342169     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.10162FP     Document Type: Article

References (26)

1. Brading AF. Spontaneous activity of lower urinary tract smooth muscles: correlation between ion channels and tissue function. J Physiol. 2006;570:13-22.
2. Imai T, Okamoto T, Yamamoto Y, Tanaka H, Koike K, Shigenobu K, et al. Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle. Acta Physiol Scand. 2001;173:323-333. (Pubitemid 33071048)
3. 2+ channels and ryanodine receptors in guinea-pig urinary bladder myocytes. J Physiol. 2002; 541:483-492.
4. Hashitani H, Brading AF. Ionic basis for the regulation of spontaneous excitation in detrusor smooth muscle cells of the guineapig urinary bladder. Br J Pharmacol. 2003;140:159-169. (Pubitemid 37175841)
5. Akino H, Chapple CR, McKay N, Cross RL, Murakami S, Yokoyama O, et al. Spontaneous contractions of the pig urinary bladder: the effect of ATP-sensitive potassium channels and the role of the mucosa. BJU Int. 2008;102:1168-1174.
6. Fry CH, Meng E, Young JS. The physiological function of lower urinary tract smooth muscle. Auton Neurosci. 2010;154:3-13.
7. Frazier EP, Mathy M-J, Peters SLM, Michel MC. Does cyclic AMP mediate rat urinary bladder relaxation by isoproterenol? J Pharmacol Exp Ther. 2005;313:260-267.
8. Uchida H, Shishido K, Nomiya M, Yamaguchi O. Involvement of cyclic AMP-dependent and -independent mechanisms in the relaxation of rat detrusor muscle via β-adrenoceptors. Eur J Pharmacol. 2005;518:195-202. (Pubitemid 41133645)
9. Wuest M, Kaden S, Hakenberg OW, Wirth MP, Ravens U. Effect of rilmakalim on detrusor contraction in the presence and absence of urothelium. Naunyn Schmiedebergs Arch Pharmacol. 2005; 372:203-212. (Pubitemid 41670683)
10. + channel opener, on guinea pig detrusor and aortic smooth muscles. Naunyn Schmiedebergs Arch Pharmacol. 2008;376:309-319.
11. Yamamoto M, Unno T, Matsuyama H, Kohda M, Masuda N, Nishimura M, et al. Two types of cation channel activated by stimulation of muscarinic receptors in guinea-pig urinary bladder smooth muscle. J Pharmacol Sci. 2008;108:248-257.
12. Hawthorn MH, Chapple CR, Cock M, Chess-Williams R. Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractility in vitro. Br J Pharmacol. 2000;129:416-419. (Pubitemid 30083861)
13. Chaiyaprasithi B, Mang CF, Kilbinger H, Hohenfellner M. Inhibition of human detrusor contraction by a urothelium derived factor. J Urol. 2003;170:1897-1900. (Pubitemid 37254955)
14. Birder LA. Urothelial signaling. Auton Neurosci. 2010;153:33-40.
15. Yoshida M, Masunaga K, Nagata T, Yono M, Homma Y. The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: pathophysiology and pharmacotherapy of overactive bladder. J Pharmacol Sci. 2010; 112:128-134.
16. Liang W, Afshar K, Stothers L, Laher I. The influence of ovariectomy and estrogen replacement on voiding patterns and detrusor muscarinic receptor affinity in the rat. Life Sci. 2002;71:351-362. (Pubitemid 34597196)
17. + channels increases contractility more in transverse than in longitudinal rat detrusor strips. Urology. 2009;73:400-404.
18. Santoso AGH, Sonarno IAB, Arsad NAB, Liang W. The role of the urothelium and ATP in mediating detrusor smooth muscle contractility. Urology. 2010;76:1267e7-1267e12.
19. Pagala MK, Tetsoti L, Nagpal D, Wise GJ. Aging effects on contractility of longitudinal and circular detrusor and trigone of rat bladder. J Urol. 2001;166:721-727. (Pubitemid 32652307)
20. Pagala M, Lehman DS, Morgan MP, Jedwab J, Wise GJ. Physiological fatigue of smooth muscle contractions in rat urinary bladder. BJU Int. 2006;97:1087-1093.
21. Liang W, Lo WN. β-adrenoceptor-mediated differences in transverse and longitudinal strips from the rat detrusor. Int Urol Nephrol. DOI:10.1007/s11255-010-9759-y.
22. 2-adrenoceptor agonist-induced relaxation of rat detrusor muscle. Eur J Pharmacol. 2000;397:169-176.
23. Herrera GM, Pozo MJ, Zvara P, Petkov GV, Bond CT, Adelman JP, et al. Urinary bladder instability induced by selective suppression of the murine small conductance calcium-activated potassium (SK3) channel. J Physiol. 2003;551:893-903. (Pubitemid 37221081)
24. Araki I, Yoshiyama M, Kobayashi H, Mochizuki T, Du S, Okada Y, et al. Emerging families of ion channels involved in urinary bladder nociception. Pharmaceuticals. 2010;3:2248-2267.
25. Darblade B, Behr-Roussel D, Oger S, Hieble J-P, Lebret T, Gorny D, et al. Effects of potassium channel modulators on human detrusor smooth muscle myogenic phasic contractile activity: potential therapeutic targets for overactive bladder. Urology. 2006; 68:442-448. (Pubitemid 44175516)
26. Takeda M, Araki I, Mochizuki T, Nakagomi H, Kobayashi H, Sawada N, et al. The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: pathophysiology of voiding dysfunction and pharmacological therapy. J Pharmacol Sci. 2010;112:121-127.