Bisphosphonate-related osteonecrosis of the jaws: A case series of 25 patients affected by osteoporosis

International Journal of Oral and Maxillofacial Surgery

Volumn 40, Issue 3, 2011, Pages 277-284

  Manfredi, M ^a   Merigo, E ^a   Guidotti, R ^a   Meleti, M ^a   Vescovi, P ^a  

^a UNIVERSITY OF PARMA   (Italy)

Author keywords

BRONJ; dental check up; dental surgery; jaws osteonecrosis; laser; oral bisphosphonates; osteoporosis

Indexed keywords

ALENDRONIC ACID; AMOXICILLIN; CLODRONIC ACID; IBANDRONIC ACID; METRONIDAZOLE; NERIDRONIC ACID; RISEDRONIC ACID; ZOLEDRONIC ACID;

ADULT; AGED; ARTICLE; BONE NECROSIS; CANCER PATIENT; CASE STUDY; CLINICAL ARTICLE; FEMALE; FOLLOW UP; FRACTURE HEALING; HUMAN; JAW OSTEONECROSIS; LASER; MUCOSA; ORAL SURGERY; OSTEOPOROSIS; PHYSICIAN; RISK FACTOR;

AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; ARTHRITIS, RHEUMATOID; BONE DENSITY CONSERVATION AGENTS; COMBINED MODALITY THERAPY; CURETTAGE; DEBRIDEMENT; DENTAL CARE; DENTAL IMPLANTS; DENTURES; DIABETES MELLITUS, TYPE 2; DIPHOSPHONATES; DRUG COMBINATIONS; FEMALE; FOLLOW-UP STUDIES; GLUCOCORTICOIDS; HUMANS; JAW DISEASES; LASER THERAPY; LASER THERAPY, LOW-LEVEL; MIDDLE AGED; OSTEONECROSIS; OSTEOPOROSIS, POSTMENOPAUSAL; PATIENT CARE PLANNING; RISK FACTORS; TOOTH EXTRACTION; WOUND HEALING;

EID: 79952317178     PISSN: 09015027     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijom.2010.11.002     Document Type: Article

References (33)

1. Abu-Id MH, Warnke PH, Gottschalk J, Springer I, Wiltfang J, Acil Y, Russo PA, Kreusch T. "Bis-phossy jaws" - high and low risk factors for bisphosphonate-induced osteonecrosis of the jaw. J Craniomaxillofac Surg 2008: 36: 95-103.
2. Advisory Task Force on Bisphosphonate- Related Ostenonecrosis of the Jaws, American Association of Oral and Maxillofacial Surgeons. Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg 2007: 65: 369-376.
3. Assael LA. Oral bisphosphonates as a cause of bisphosphonate-related osteonecrosis of the jaws: clinical findings, assessment of risks and preventive strategies. J Oral Maxillofac Surg 2009: 67: 35-43.
4. Capsoni F, Longhi M, Weinstein R. Bisphosphonate-associated osteonecrosis of the jaw: the rheumatologist's role. Arthritis Res Ther 2006: 8: 219.
5. Chen CH, Hung HS, Hsu SH. Low-energy laser irradiation increases endothelial cell proliferation, migration, and eNOS gene expression possibly via PI3K signal pathway. Lasers Surg Med 2008 Jan: 40: 46-54.
6. Corazza AV, Jorge J, Kurachi C, Bagnato VS. Photobiomodulation on the angiogenesis of skin wounds in rats using different light sources. Photomed Laser Surg 2007: 25: 102-106.
7. Da Silva JP, Da Silva MA, Almeida AP, Lombardi Junior I, Matos AP. Laser therapy in the tissue repair process: a literature review. Photomed Laser Surg 2010: 28: 17-21.
8. Favia G, Pilolli GP, Maiorano E. Osteonecrosis of the jaw correlated to bisphosphonate therapy in non-oncologic patients: clinico-pathological features of 24 patients. J Rheumatol 2009: 36: 2780-2787.
9. Felsenberg D, Hoffmeister B, Amling M. Onkologie: Kiefernekrosen nach hoch dosierter bisphosphonatat thereapie. Dtsch rztebl 2006: 103: A-3078.
10. Hoff AO, Toth BB, Altundag K, Johnson MM, Warneke CL, Hu M, Nooka A, Sayegh G, Guarneri V, Desrouleaux K, Cui J, Adamus A, Gagel RF, Hortobagyi GN. Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates. J Bone Miner Res 2008: 23: 826-836.
11. Iwamoto J, Takeda T, Sato Y. Efficacy and safety of alendronate and risedronate for postmenopausal osteoporosis. Curr Med Res Opin 2006: 22: 919-928.
12. Khosla S, Burr D, Cauley J, Dempster DW, Ebeling PR, Felsenberg D, Gagel RF, Gilsanz V, Guise T, Koka S, Mccauley LK, Mcgowan J, Mckee MD, Mohla S, Pendrys DG, Raisz LG, Ruggiero SL, Shafer DM, Shum L, Silverman SL, Van Poznak CH, Watts N, Woo SB, Shane E. American Society for Bone and Mineral Research.-Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 2007: 2: 1479-1491.
13. Lo JC, O'Ryan FS, Gordon NP, Yang J, Hui RL, Martin D, Hutchinson M, Lathon PV, Sanchez G, Silver P, Chandra M, McCloskey CA, Staffa JA, Willy M, Selby JV, Go AS. Predicting Risk of Osteonecrosis of the Jaw with Oral Bisphosphonate Exposure (PROBE) Investigators. Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure. J Oral Maxillofac Surg 2010: 68: 243-253.
14. Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 2003: 61: 1115-1117.
15. Marx RE, Cillo Jr JE, Ulloa JJ. Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatment. J Oral Maxillofac Surg 2007: 65: 2397-2410.
16. Mavrokokki T, Cheng A, Stein B, Goss A. Nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in Australia. J Oral Maxillofac Surg 2007: 65: 415-423.
17. Merigo E, Manfredi M, Meleti M, Corradi D, Vescovi P. Jaw bone necrosis without previous dental extractions associated with the use of bisphosphonates (pamidronate and zoledronate): a four-case report. J Oral Pathol Med 2005: 34: 613-617.
18. Murad OM, Arora S, Farag AF, Guber HA. Bisphosphonates and osteonecrosis of the jaw: a retrospective study. Endocr Pract 2007: 13: 232.
19. Pazianas M, Miller P, Blumentals WA, Bernal M, Kothawala P. A review of the literature on osteonecrosis of the jaw in patients with osteoporosis treated with oral bisphosphonates: prevalence, risk factors, and clinical characteristics. Clin Ther 2007: 29: 1548-1558.
20. Rizzoli R, Burlet N, Cahall D, Delmas PD, Eriksen EF, Felsenberg D, Grbic J, Jontell M, Landesberg R, Laslop A, Wollenhaupt M, Papapoulos S, Sezer O, Sprafka M, Reginster JY. Osteonecrosis of the jaw and bisphosphonate treatment for osteoporosis. Bone 2008: 42: 841-847.
21. Rodrigo SM, Cunha A, Pozza DH, Blaya DS, Moraes JF, Weber JB, De Oliveira MG. Analysis of the systemic effect of red and infrared laser therapy on wound repair. Photomed Laser Surg 2009: 27: 929-935.
22. Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE, Mehrotra B. American Association of Oral and Maxillofacial Surgeons.American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws-2009 update. J Oral Maxillofac Surg 2009: 67: 2-12.
23. Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff SL. Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg 2004: 62: 527-534.
24. Sedghizadeh PP, Stanley K, Caligiuri M, Hofkes S, Lowry B, Shuler CF. Oral bisphosphonate use and the prevalence of osteonecrosis of the jaw: an institutional inquiry. J Am Dent Assoc 2009: 140: 61-66.
25. Silverman SL, Landesberg R. Osteonecrosis of the jaw and the role of bisphosphonates: a critical review. Am J Med 2009: 122: S33-S45.
26. Stafford RS, Drieling RL, Hersh AL. National trends in osteoporosis visits and osteoporosis treatment, 1988-2003. Arch Intern Med 2004: 164: 1525-1530.
27. Tuby H, Maltz L, Oron U. Modulations of VEGF and iNOS in the rat heart by low level laser therapy are associated with cardioprotection and enhanced angiogenesis. Lasers Surg Med 2006: 38: 682-688.
28. Vescovi P, Merigo M, Meleti M, Manfredi M. Bisphosphonate-associated osteonecrosis of the jaw: a possible treatment? J Oral Maxillofac Surg 2006: 64: 1460-1462.
29. Vescovi P, Manfredi M, Merigo E, Meleti M. Early surgical approach preferable to medical therapy for bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg 2008: 66: 831-832.
30. Vescovi P, Manfredi M, Merigo E, Meleti M, Fornaini C, Rocca JP, Nammour S. Surgical approach with Er:YAG laser on osteonecrosis of the jaws (ONJ) in patients under bisphosphonate therapy (BPT). Lasers Med Sci 2009: 25: 101-113.
31. Wessel JH, Dodson TB, Zavras AI. Zoledronate, smoking, and obesity are strong risk factors for osteonecrosis of the jaw: a case-control study. J Oral Maxillofac Surg 2008: 66: 625-631.
32. Woo SB, Hellstein JW, Kalmar J. Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws. Ann Intern Med 2006: 144: 753-761.
33. Yarom N, Yahalom R, Shoshani Y, Hamed W, Regev E, Elad S. Osteonecrosis of the jaw induced by orally administered bisphosphonates: incidence, clinical features, predisposing factors and treatment outcome. Osteoporos Int 2007: 18: 1363-1370.