Relationship between the prenatal exposure to low-level of mercury and the size of a newborn's cerebellum

Medical Hypotheses

Volumn 76, Issue 4, 2011, Pages 514-516

  Cace, I Bilic ^a   Milardovic, A ^b   Prpic, I ^b   Krajina, R ^a   Petrovic, O ^a   Vukelic, P ^b   Spiric, Z ^c   Horvat, M ^d   Mazej, D ^d   Snoj, J ^d  

^a KBC RIJEKA   (Croatia)

^b UNIVERSITY OF RIJEKA   (Croatia)

^c Department of Natural Resources Management   (Croatia)

^d JO EF STEFAN INSTITUTE   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLMERCURY;

ADULT; ARTICLE; BRAIN SIZE; CEREBELLUM; CONTROLLED STUDY; FEMALE; FETUS ECHOGRAPHY; HAIR LEVEL; HUMAN; MAJOR CLINICAL STUDY; NEUROIMAGING; NEWBORN; PREGNANCY; PREGNANT WOMAN; PRENATAL EXPOSURE; PROSPECTIVE STUDY;

ADULT; CEREBELLUM; CHILD; FEMALE; HAIR; HUMANS; INFANT, NEWBORN; MATERNAL EXPOSURE; METHYLMERCURY COMPOUNDS; ORGAN SIZE; PREGNANCY; PROSPECTIVE STUDIES;

EID: 79952313737     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2010.12.005     Document Type: Article

References (20)

1. Pirrone N, Ahrens R, Barregard L, et al., EU ambient air pollution by Mercury (Hg) - Position paper on mercury. Brussels: Office for Official Publications of the European Communities; 2001. URL: [accessed 19 Feb 2007]. http://ec.europa.eu/environment/air/pdf/pp_mercury_toc.pdf.
2. US EPA (US Environmental Protection Agency). An assessment of exposure to mercury in the United States. A mercury study report to congress, vol. IV, Washington DC; 1997. URL: [accessed 19 Feb 2007]. http://www.epa.gov/mercury/report.htm.
3. World Health Organization. Environmental health criteria 101: methylmercury. Geneva, Switzerland: World Health Organization; 1990.
4. Toffleson L., Cordle F. Methylmercury in fish: a review of residual levels, fish consumption, and regulatory action in the United States. Environ Health Perspect 1986, 68:2038.
5. Goyer R.A. Toxic effects of metals: mercury. Casarett and Doull's toxicology: the basic science of poisons 1996, 709. McGraw-Hill, New York. 5th ed. C.D. Klaassen (Ed.).
6. Kajiwara Y., Yasutake A., Adachi T., Hirayama K. Methylmercury transport across the placenta via neutral amino acid carrier. Arch Toxicol 1996, 70(5):3104.
7. Oskarsson A., Palminger Hallen I., Sundberg J., Petersson Grawe K. Risk assessment in relation to neonatal metal exposure. Analyst 1998, 123(1):1923.
8. National Academy of Sciences. Toxicological effects of methylmercury, Washington, DC: National Research Council; 2000.
9. Choi B.H., Lapham L.W., AminZaki L., Saleem T. Abnormal neuronal migration, deranged cerebral cortical organization, and diffuse white matter astrocytosis of human fetal brain: a major effect of methylmercury poisoning in utero. Neuropathol Exp Neurol 1978, 37(6):719-733.
10. Lapham L.W., Cernichiari E., Cox C., et al. An analysis of autopsy brain tissue from infants prenatally exposed to methylmercury. Neurotoxicology 1995, 16(4):689-704.
11. Rice D., Barone S. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ Health Perspect 2000, 108(3):511-533.
12. Davidson P.W., Myers G.J., Cox C., et al. Effects of prenatal and postnatal methylmercury exposure from fish consumption and neurodevelopment. JAMA 1998, 280(8):701-707.
13. Harada M. Minamata disease: methylmercury poisoning in Japan caused by environmental pollution. Crit Rev Toxicol 1995, 25:1-24.
14. Igata A. Epidemiological and clinical features of Mianmata disease. Environ Res 1993, 63(1):157-169.
15. Debes F., Budtz-Jorgensen E., Weihe P., White R.F., Grandjean P. Impact of prenatal methylmercury exposure on neurobehavioral function at age of 14 years. Neurotoxicol Teratol 2006, 28(5):536-547.
16. Grandjean P., Weihe P., White R.F., et al. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol 1997, 19:417-428.
17. Cheuk D.K., Wong V. Attention-deficit hyperactivity disorder and blood mercury level: a case control study in Chinese children. Neuropediatrics 2006, 37(4):234-240.
18. Ramon R., Ballester F., Aguinagalde X., et al. Fish consumption during pregnancy, prenatal mercury exposure, and anthropometric measures at birth in a prospective mother-infant cohort study in Spain. Am J Clin Nutr 2009, 90:1047-1055.
19. Leijser L.M., Srinivasan L., Rutherford M.A., Counsell S.J., Allsop J.M., Cowan F.M. Structural linear measurements in the newborn brain: accuracy of cranial ultrasound compared to MRI. Pediatr Radiol 2007, 37(7):640-648.
20. Schober S.E., Sinks T.H., Jones R.L., et al. Blood mercury levels in US children and women of childbearing age, 1999-2000. JAMA 2003, 289(13):1667-1674.