Dextran glucosidase: A potential target of iminosugars in caries prevention

Medical Hypotheses

Volumn 76, Issue 4, 2011, Pages 574-575

  Zhang, Ru ^a   Zhang, Wanmei ^a   Hu, Tao ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1 DEOXYNOJIRIMYCIN; 1,3 ALPHA GLUCAN; CARBOHYDRATE; DEXTRAN; DEXTRAN GLUCOSIDASE; GLUCOSE; GLUCOSIDASE; GLYCOSIDASE INHIBITOR; GLYCOSYLTRANSFERASE; GLYCOSYLTRANSFERASE INHIBITOR; IMINOSUGAR; POLYSACCHARIDE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL VIRULENCE; BIOFILM; CARBOHYDRATE ANALYSIS; CARBOHYDRATE METABOLISM; CARBOHYDRATE SYNTHESIS; CARIES PREVENTION; CHEMICAL MODIFICATION; DENTAL CARIES; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; MICROBIAL ACTIVITY; MOUTH DISEASE; STREPTOCOCCUS MUTANS;

BIOFILMS; DENTAL CARIES; GLUCOSIDASES; HUMANS; IMINO SUGARS; POLYSACCHARIDES;

EID: 79952312119     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2011.01.004     Document Type: Article

References (18)

1. Compain P., Martin O.R. Design, synthesis and biological evaluation of iminosugar-based glycosyltransferase inhibitors. Curr Top Med Chem 2003, 3(5):541-560.
2. Iminosugars: from synthesis to therapeutic applications 2007, Weinheim, Wiley-VCH. P. Compain, O.R. Martin (Eds.).
3. Asano N., Tomioka E., Kizu H., Matsui K. Sugars with nitrogen in the ring isolated from the leaves of Morus bombycis. Carbohyd Res 1994, 253:235-245.
4. Gerber-Lemaire S., Popowycz F., Rodriguez-Garcia E., Asenjo A.T.C., Robina I., Vogel P. An efficient combinatorial method for the discovery of glycosidase inhibitors. ChemBioChem 2002, 3(5):466-470.
5. Martin O.R., Compain P. Iminosugars: recent insights into their bioactivity and potential as therapeutic agents. Curr Top Med Chem 2003, 3(5):471-591.
6. Islam Barira, Khan Shahper N, Haque Irfanul, Alam M, Mushfiq M, Khan Asad U. Novel anti-adherence activity of mulberry leaves: inhibition of Streptococcus mutans biofilm by 1-deoxynojirimycin isolated from Morus alba. J Antimicrob Chemother 2008;62(4):751-757.
7. Devulapalle K.S., Goodman S.D., Gao Q., Hemsley A., Mooser G. Knowledge-based model of a glucosyltransferase from the oral bacterial group of mutans streptococci. Protein Sci 1997, 6(12):2489-2493.
8. Monchois V., Vignon M., Escalier P.C., Svensson B., Russell R.R.B. Involvement of Gln937 of Streptococcus downei GTF-I glucansucrase in transition-state stabilization. Eur J Biochem 2000, 267(13):4127-4136.
9. Igarashi T., Yamamoto A., Goto N. Characterization of the dextranase gene (dex) of Streptococcus mutans and its recombinant product in an Escherichia coli host. Microbiol Immunol 1995, 39(6):387-391.
10. Spatafora G.A., Sheets M., June R., et al. Regulated expression of the Streptococcus mutans dit gene correlates with intracellular polysaccharide accumulation. J Bacteriol 1999, 181(8):2362-2372.
11. Vu B., Chen M., Crawford R.J., Ivanova E.P. Bacterial extracellular polysaccharides involved in biofilm formation. Molecules 2009, 14(7):2535-2554.
12. Burne R.A., Quivey R.G., Marguis R.E. Physiologic homeostasis and stress responses in oral biofilms. Methods Enzymol 1999, 310:441-460.
13. Hayacibara M.F., Koo F., Smith A.M.V., et al. The influence of mutanase and dextranase on the production and structure of glucans synthesized by streptococcal glucosyltransferases. Carbohyd Res 2004, 339:2127-2137.
14. Taniguchi N, Honke K, Fukuda M (Eds.). Handbook of glycosyltransferases and related genes. Springer; 2002.
15. Aoki H., Shiroza T., Hayakawa M., et al. Cloning of a Streptococcus mutans glucosyltransferase gene coding for insoluble glucan synthesis. Infect Immun 1986, 53(3):587-594.
16. Saburi W., Mori H., Saito S., Okuyama M., Kimura A. Structural elements in dextran glucosidase responsible for high specificity to long chain substrate. BBA - Proteins Proteom 2006, 1764(4):688-698.
17. Ahn Sang-Joon, Wen ZeZhang T, Burne Robert A. Multilevel control of competence development and stress tolerance in Streptococcus mutans UA159. Infect Immun 2006;74(3):1631-1642.
18. McNeill Karol, Hmilton IR. Acid tolerance response of biofilm cells of Streptococcus mutans. FEMS Microbiol Lett 2003;221(1):25-30.