Alginate in the treatment of extra-esophageal reflux

Effects, Diagnosis and Management of Extra-Esophageal Reflux

Volumn , Issue , 2012, Pages 145-156

  Strugala, Vicki ^a   Dettmar, Peter W ^a  

^a The Deep Business Centre   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79952310058     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (21)

1. Smidsrod, O. and K.I. Draget, Chemistry and physical properties of alginates. Carbohydr. Eur., 1996. 14: p. 6.
2. Onsoyen, E., Commercial applications of alginates. Carbohydr. Eur., 1996. 14: p. 26.
3. Skjak-Braek, G. and T. Espevik, Application of alginate gels in biotechnology and biomedicine. Carbohydr. Eur., 1996. 14: p. 19.
4. Chatfield, S., A comparison of the efficacy of the alginate preparation, Gaviscon Advance, with placebo in the treatment of gastro-oesophageal reflux disease. Curr Med Res Opin, 1999. 15(3): p. 152-159.
5. Chevrel, B., A comparative crossover study on the treatment of heartburn and epigastric pain: Liquid Gaviscon and a magnesium - aluminium antacid gel. J Int Med Res, 1980. 8: p. 300-302.
6. Lindow, S.W., P. Regnell, J. Sykes, and S. Little, An open-label, multicentre study to assess the safety and efficacy of a novel reflux suppressant (Gaviscon Advance) in the treatment of heartburn during pregnancy. Int J Clin Pract, 2003. 57: p. 175-179.
7. Dettmar, P.W., F.C. Hampson, J. Taubel, U. Lorch, L.M. Johnstone, J. Sykes, and P.J. Berry, The suppression of gastro-oesophageal reflux by alginates. Int J Clin Pract, 2007. 61(10): p. 1654-1662.
8. Poynard, T., Relapse rate of patients after healing of oesophagitis - a prospective study of alginate as self-care treatment for 6 months. Aliment Pharmacol Ther, 1993. 7: p. 385-392.
9. Bryan, J.L., S.L. Little, J. Sykes, T. Baxter, and P.W. Dettmar, Efficacy and safety of a unique anti-reflux agent, Gaviscon Advance, for the treatment of heartburn in pregnancy. Gastroenterology, 2001. 120(5): p. 2214.
10. Dettmar, P.W., J. Sykes, S.L. Little, and J. Bryan, Rapid onset of effect of sodium alginate on gastro-oesophageal reflux compared with ranitidine and omeprazole, and relationship between symptoms and reflux episodes. Int J Clin Pract, 2006. 60(3): p. 275-283.
11. Dettmar, P.W., F.C. Hampson, A. Jain, S. Choubey, S.L. Little, and T. Baxter, Administration of an alginate based gastric reflux suppressant on the bioavailability of omeprazole. Indian J Med Res, 2006. 123(4): p. 517-524.
12. Hampson, F.C., A. Farndale, V. Strugala, J. Sykes, I.G. Jolliffe, and P.W. Dettmar, Alginate rafts and their characterisation. Int J Pharm, 2005. 294: p. 137-147.
13. Gaviscon Advance Aniseed Suspension SmPC November 2008.
14. Belafsky, P.C., G.N. Postma, and J.A. Koufman, Validity and reliability of the reflux symptom index (RSI). Journal of Voice, 2002. 16(2): p. 274-277.
15. Belafsky, P.C., G.N. Postma, and J.A. Koufman, The validity and reliability of the reflux finding score (RFS). Laryngoscope, 2001. 111: p. 1313-1317.
16. McGlashan, J.A., L.M. Johnstone, V. Strugala, and P.W. Dettmar, The value of a liquid alginate suspension (Gaviscon Advance) in the management of laryngo-pharyngeal reflux European Archives of Oto-Rhino-Laryngology and Head & Neck, 2009. 266(2): p. 243-251.
17. Ojoo, J.C., S.A. Mulrennan, J.A. Kastelik, C. Wright, C.F. Everett, P.W. Dettmar, and A.H. Morice, Role of high strength alginates in chronic cough associated with gastro-oesophageal reflux disease. J Clin Gastroenterol, 2004. 38(2): p. 141.
18. Strugala, V., E.J. Kennington, R.J. Campbell, G. Skjak-braek, and P.W. Dettmar, Inhibition of pepsin activity by alginates in vitro and the effect of epimerization. Int J Pharm, 2005. 304(1-2): p. 40-50.
19. Strugala, V., J. Avis, L.M. Johnstone, I.G. Jolliffe, and P.W. Dettmar, An alginate raft forming suspension is able to inhibit pepsin activity. Gut, 2008. 57(Suppl 1): p. A130.
20. Strugala, V., J. Avis, L.M. Johnstone, I.G. Jolliffe, and P.W. Dettmar, Can alginates prevent pepsin and bile acid damage to the esophagus during gastro-esophageal reflux? Gastroenterology, 2008. 134(1 (Suppl 1)): p. A-177.
21. Strugala, V., J. Avis, L.M. Johnstone, I.G. Jolliffe, and P.W. Dettmar, Retention of pepsin and bile acids (aggressors) within the gastric refluxate by the buoyant raft formed by an alginate-containing antireflux agent. J Clin Gastroenterol, 2008. 42(Suppl 1): p. S13-S14.