Age-related changes in apoptosis and expressions of intercellular adhesion molecule-1 and vascular endothelial growth factor receptor type 2 in the wall of varicose veins

International Angiology

Volumn 29, Issue 6, 2010, Pages 507-513

  Simovart, H E ^a   Aunapuu, M ^a   Lieberg, J ^a   Roosaar, P ^a   Arend, A ^a  

^a UNIVERSITY OF TARTU   (Estonia)

Author keywords

Apoptosis; Endothelial cells; Smooth muscle cells; Varicose veins

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; PROTEIN BAX; VASCULOTROPIN RECEPTOR 2;

ADULT; AGE DISTRIBUTION; AGING; APOPTOSIS; ARTICLE; BLOOD VESSEL WALL; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NICK END LABELING; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; STATISTICAL SIGNIFICANCE; SUBENDOTHELIUM; TUNICA MEDIA; VARICOSIS; VASCULAR ENDOTHELIUM;

ADULT; AGE FACTORS; ANALYSIS OF VARIANCE; APOPTOSIS; ENDOTHELIAL CELLS; ESTONIA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INTERCELLULAR ADHESION MOLECULE-1; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; SAPHENOUS VEIN; VARICOSE VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 79952306787     PISSN: 03929590     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Springer TA. Adhesion receptors of the immune system. Nature 1990;346:425-434.
2. Pober JS. The role of endothelial T cells in inflammation. Transplantation 1990;50:537-44.
3. Taylor PM, Rose ML, Yacoub MH, Pigott R. Induction of vascular adhesion molecules during rejection of human cardiac allografts. Transplantation 1992;54:451-7.
4. Choy JC, Granville DJ, Hunt DWC, McManus BM. Endothelial Cell Apoptosis: Biochemical Characteristics and Implications for Atherosclerosis. J Mol Cell Cardiol 2001;33:1673-90.
5. Sata M, Walsh K. TNF alpha regulation of Fas ligand expression on the vascular endothelium modulates leukocyte extravasation. Nat Med 1998;4:415-20. (Pubitemid 28212756)
6. Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L. VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol 2006;7:359-71.
7. Gerber HP, Mcurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V et al. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem 1998;273:30336-43. (Pubitemid 28545503)
8. Hollingsworth SJ, Powell G, Barker SG, Cooper DG. Primary Varicose Veins: Altered Ttranscription of VEGF and its Receptors (KDR, flt-1, Soluble flt-1) with Saphenofemoral Junction Incompetence. Eur J Vasc Endovasc Surg 2004;27:259-68. (Pubitemid 38268331)
9. Bombell TA, Karsan JF, Tait F, Harlan M. Apoptotic vascular endothelial cells become procoagulant. Blood 1997;89:2429-42.
10. Sayer GL, Smith PD. Immunocytochemical characterisation of the inflammatory cell infiltrate of varicose veins. Eur J Vasc Endovasc Surg 2004;28:479-83. (Pubitemid 39307439)
11. Sumpio BE, Riley JT, Dardik A. Cells in focus: endothelial cell. Int J Biochem Cell Biol 2002;34:1508-12.
12. Michiels C, Arnould T, Janssens D, Bajou K, Geron I, Remacle J. Interactions between endothelial cells and smooth muscle cells after their activation by hypoxia. A possible etiology for venous disease. Int Angiol 1996;15:124-30.
13. Michiels C, Bouaziz N, Remacle J. Role of the endothelium and blood stasis in the appearance of varicose veins. Int Angiol 2002;21:1-8. (Pubitemid 34413648)
14. McGill SN, Ahmed NA, Christou NV. Endothelial cells: role in infection and inflammation. World J Surg 1998;22:171-8. (Pubitemid 28065184)
15. Fukuo K, Hata S, Suhara T, Nakahashi T, Shinto Y, Tsujmoto Y et al. Nitric oxide induces upregulation of Fas and apoptosis in vascular smooth muscle. Hypertension 1996;27:823-6.
16. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999;399:601-5.
17. Fulton D, Gratton JP, McCabe TJ, Fontana J, Fuijo Y, Walsh K et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999;399:597-601.
18. Hoffmann J, Haendeler J, Aicher A, Rössig, L, Vasa M, Zeiher AM et al. Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide. Circ Res 2001;89:709-15. (Pubitemid 34627071)
19. Urbanek T, Skop B, Wiaderkiewicz R, Wilczok T, Ziaja K, Lebda-Wyborny T et al. Smooth muscle cell apoptosis in primary varicose veins. Eur J Vasc Endovasc Surg 2004;28:600-11. (Pubitemid 39462651)
20. Ducasse E, Giannakakis K, Chevalier J, Dasnoy D, Puppinck P, Speziale F et al. Dysregulated apoptosis in primary varicose veins. Eur J Vasc Endovasc Surg 2005;29:316-23. (Pubitemid 40267975)
21. Ascher E, Jacob T, Hingorani A, Tsemekhin B, Gunduz Y. Expression of molecular mediators of apoptosis and their role in the pathogenesis of lower-extremity varicose veins. J Vasc Surg 2001;33:1080-6. (Pubitemid 33586354)
22. Bujaén J, Jiménez-Cossio JA, Jurado F, Gimeno MJ, Pascual G, Garcia-Honduvilla N et al. Evaluation of the smooth muscle cell component and apoptosis in the varicose vein wall. Histol Histopathol 2000;15:745-52.
23. Sata M, Suhara T, Walsh K. Vascular endothelial cells and smooth muscle cells differ in expression of Fas and Fas ligand and in sensitivity to Fas ligand-induced cell death: implications for vascular disease and therapy. Arterioscler Thromb Vasc Biol 2000; 20:309-16. (Pubitemid 30086085)
24. Sata M, Walsh K. 1998. Endothelial cell apoptosis induced by oxidized LDL is associated with the down-regulation of the cellular caspase inhibitor FLIP. J Biol Chem 1998;273:33103-6. (Pubitemid 29005675)
25. Neufeld GT, Cohen T, Gengrinovitch S, Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 1999;13:9-22. (Pubitemid 29038270)