Serum pigment epithelium-derived factor is elevated in women with polycystic ovary syndrome and correlates with insulin resistance

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 3, 2011, Pages 831-836

  Yang, Shumin ^a   Li, Qifu ^a   Zhong, Li ^a   Song, Ying ^a   Tian, Bo ^a   Cheng, Qingfeng ^a   Qing, Hua ^a   Xia, Wei ^a   Luo, Mei ^a   Mei, Mei ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PIGMENT EPITHELIUM DERIVED FACTOR; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CLINICAL RESEARCH; CONTROLLED STUDY; CORRELATION ANALYSIS; DIASTOLIC BLOOD PRESSURE; FEMALE; HUMAN; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPOLYSIS; MAJOR CLINICAL STUDY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE;

ADULT; BLOOD PRESSURE; CHOLESTEROL, HDL; CHOLESTEROL, LDL; EYE PROTEINS; FEMALE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MULTIVARIATE ANALYSIS; NERVE GROWTH FACTORS; OBESITY; OVERWEIGHT; POLYCYSTIC OVARY SYNDROME; SERPINS; TRIGLYCERIDES; WAIST CIRCUMFERENCE; YOUNG ADULT;

EID: 79952306356     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-2140     Document Type: Article

References (27)

1. Ehnnann DA 2005 Polycystic ovary syndrome. N Engl J Med 352:1223-1236
2. Norman RJ, Dewailly D, Legro RS, Hickey TE 2007 Polycystic ovary syndrome. Lancet 370:685-697 (Pubitemid 47285318)
3. Acien P, Quereda F, Matallin P, Villarroya E, Lopez-Fernandez JA, Acien M, Mauri M, Alfayate R 1999 Insulin, androgens, and obesity in women with and without polycystic ovary syndrome: a heterogeneous group of disorders. Fertil Steril 72:32-40 (Pubitemid 29300258)
4. Ehrmann DA, Barnes RB, Rosenfield RL, Cavaghan MK, Imperial J 1999 Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care 22:141-146 (Pubitemid 29028311)
5. Lakhani K, Prelevic GM, Seifalian AM, Atiomo WU, Hardiman P 2004 Polycystic ovary syndrome, diabetes and cardiovascular disease: risks and risk factors. J Obstet Gynaecol 24:613-621 (Pubitemid 39655416)
6. Wang Y, Qu J, Wu X, Hou L, Erkkola R 2010 Different phenotypes of polycystic ovary syndrome by Rotterdam criteria are differently steroidogenic but similarly insulin resistant. Fertil Steril 93:1362-1365
7. Svendsen PF, Madsbad S, Nilas L 2010 The insulin-resistant phenotype of polycystic ovary syndrome. Fertil Steril 94:1052-1058
8. Shumak SL 2009 Even lean women with PCOS are insulin resistant. BMJ 338:b954
9. Galluzzo A, Amato MC, Giordano C 2008 Insulin resistance and polycystic ovary syndrome. Nutr Metab Cardiovasc Dis 18:511-518
10. Ronti T, Lupattelli G, Mannarino E 2006 The endocrine function of adipose tissue: an update. Clin Endocrinol 64:355-365
11. Carmina E, Orio F, Palomba S, Longo RA, Cascella T, Colao A, Lombardi G, Rini GB, Lobo RA 2006 Endothelial dysfunction in PCOS: role of obesity and adipose hormones. Am J Med 119:356.e1-356.e6.
12. Orio Jr F, Palomba S, Cascella T, Milan G, Mioni R, Pagano C, Zullo F, Colao A, Lombardi G, Vettor R 2003 Adiponectin levels in women with polycystic ovary syndrome. J Clin Endocrin Metab 88:2619-2623 (Pubitemid 36724434)
13. Crowe S, Wu LE, Economou C, Turpin SM, Matzaris M, Hoehn KL, Hevener AL, James DE, Duh EJ, Watt MJ 2009 Pigment epithelium-derived factor contributes to insulin resistance in obesity. Cell Metab 10:40-47
14. Yamagishi S, Adachi H, Abe A, Yashiro T, Enomoto M, Furuki K, Hino A, Jinnouchi Y, Takenaka K, Matsui T, Nakamura K, Imaizumi T 2006 Elevated serum levels of pigment epithelium - derived factor (PEDF) in the metabolic syndrome. J Clin Endocrin Metab 91:2447-2450 (Pubitemid 43855041)
15. Stejskal D, Karpísek M, Svesták M, Hejduk P, Sporová L, Kotolová H 2010 Pigment epithelium-derived factor as a new marker of metabolic syndrome in Caucasian population. J Clin Lab Anal 24:17-19
16. Nakamura K, Yamagishi S, Adachi H, Matsui T, Kurita Y, Imaizumi T 2010 Serum levels of pigment epithelium-derived factor (PEDF) are an independent determinant of insulin resistance in patients with essential hypertension. Int J Cardiol 143:96-98
17. Rotterdam ESHRE/ASRM - Sponsored PCOS Consensus Workshop Group 2004 Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19:41-47
18. Weiping L, Qingfeng C, Shikun M, Xiurong L, Hua Q, Xiaoshu B, Suhua Z, Qifu L 2006 Elevated serum RBP4 is associated with insulin resistance in women with polycystic ovary syndrome. Endocrine 30:283-287. (Pubitemid 47010964)
19. Chen C, Lu FC 2004 Guidelines for prevention and control of overweight and obesity in chinese adults. Biomed Environ Sci 17(Suppl):1-36
20. Lewanczuk RZ, Paty BW, Toth EL 2004 Comparison of the [13C] glucose breath test to the hyperinsulinemic - euglycemic clamp when determining insulin resistance. Diabetes Care 27:441-447 (Pubitemid 38174069)
21. Monzillo LU, Hamdy O 2003 Evaluation of insulin sensitivity in clinical practice and in research settings. Nutr Rev 61:397-412 (Pubitemid 38140057)
22. Caumo A, Perseghin G, Brunani A, Luzi L 2006 New insights on the simultaneous assessment of insulin sensitivity and beta - cell function with the HOMA2 method. Diabetes Care 29:2733-2734 (Pubitemid 44912210)
23. Mojiminiyi OA, Abdella NA 2010 Effect of homeostasis model assessment computational method on the definition and associations of insulin resistance. Clin Chem Lab Med 48:1629-1623
24. Diamanti-Kandarakis E, Kouli C, Alexandraki K, Spina G 2004 Failure of mathematical indices to accurately assess insulin resistance in lean, overweight, or obese women with polycystic ovary syndrome. J Clin Endocrinol Metab 89:1273-1276
25. Jenkins A, Zhang SX, Gosmanova A, Aston C, Dashti A, Baker MZ, Lyons T, Ma JX 2008 Increased serum pigment epithelium derived factor levels in Type 2 diabetes patients. Diabetes Res Clin Pract 81:e4-e7
26. Katakami N, Kaneto H, Yamasaki Y, Matsuhisa M 2008 Increased serum pigment epithelium-derived factor levels in type 1 diabetic patients with diabetic retinopathy. Diabetes Res Clin Pract 82:e5-e7
27. Sabater M, Moreno-Navarrete JM, Ortega FJ, Pardo G, Salvador J, Ricart W, Frühbeck G, Fernández-Real JM 2010 Circulating Pigment Epithelium-Derived Factor Levels Are Associated with Insulin Resistance and Decrease after Weight Loss. J Clin Endocrinol Metab 95:4720-4728